CAF-mediated regulation of prostate cancer stem cell stemness via the Wnt/β-catenin and SDF-1/CXCR4 pathways in castration-resistant prostate cancer

CAF-mediated regulation of prostate cancer stem cell stemness via the Wnt/β-catenin and SDF-1/CXCR4 pathways in castration-resistant prostate cancer

IntroductionThe role of cancer-associated fibroblasts (CAFs) in the progression, therapeutic resistance, and metastasis of castration-resistant prostate cancer (CRPC) remains incompletely understood. This study aimed to investigate how CAFs regulate the stemness of prostate cancer stem cells (PCSCs)...

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Main Authors: Haoran Chen, Zhen Li, Yuan Yue, Xudong Zhu, Jiazheng Wang, Yafei Chen, Yilin Wang, Zhanyang Luo, Hao Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
castration-resistant prostate cancer
cancer-associated fibroblast
prostate cancer stem cell
Wnt/β-catenin
SDF-1/CXCR4
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1617200/full
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