Multidisciplinary Team Approach in Prostate-Specific Membrane Antigen Theranostics for Prostate Cancer: A Narrative Review
In managing prostate cancer, the integration of multidisciplinary team (MDT) with prostate-specific membrane antigen (PSMA) theranostics marks a significant advancement, addressing the disease's spectrum from indolent forms to aggressive metastatic stages. MDTs, comprising urology, oncology, ra...
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| Format: | Article |
| Language: | English |
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Korean Urological Oncology Society
2024-03-01
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| Series: | Journal of Urologic Oncology |
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| Online Access: | http://www.e-juo.org/upload/pdf/juo-244600200010.pdf |
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| _version_ | 1846143063810899968 |
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| author | Minseok Suh Gi Jeong Cheon |
| author_facet | Minseok Suh Gi Jeong Cheon |
| author_sort | Minseok Suh |
| collection | DOAJ |
| description | In managing prostate cancer, the integration of multidisciplinary team (MDT) with prostate-specific membrane antigen (PSMA) theranostics marks a significant advancement, addressing the disease's spectrum from indolent forms to aggressive metastatic stages. MDTs, comprising urology, oncology, radiation oncology, pathology, radiology, and nuclear medicine experts, are pivotal in delivering tailored, evidence-based care, essential for the varied clinical presentations of prostate cancer. The introduction of PSMA-targeted theranostics and PSMA positron emission tomography imaging has impacted the approach to diagnosis and treatment, offering enhanced precision in disease localization and enabling more nuanced management strategies for conditions such as oligometastatic prostate cancer, metastatic hormone-sensitive prostate cancer, and metastatic castration-resistant prostate cancer. The collaborative approach of MDTs in utilizing PSMA-targeted radioligand therapy emphasizes meticulous patient selection, predictive assessment of therapy response, and careful management of therapy-related toxicities. Additionally, recent strategies, including combination therapies from ENZA-P and Lu-PARP trials, show potential for improving treatment efficacy. This unified approach showcases the critical role of MDTs in optimizing treatment outcomes, underscoring the importance of collaboration in advancing the treatment of prostate cancer with PSMAtargeted therapies, thereby setting a new paradigm in personalized prostate cancer management. |
| format | Article |
| id | doaj-art-421c02edd92646f5bdf5e7715ddf7292 |
| institution | Kabale University |
| issn | 2951-603X 2982-7043 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Korean Urological Oncology Society |
| record_format | Article |
| series | Journal of Urologic Oncology |
| spelling | doaj-art-421c02edd92646f5bdf5e7715ddf72922024-12-03T04:18:38ZengKorean Urological Oncology SocietyJournal of Urologic Oncology2951-603X2982-70432024-03-01221112010.22465/juo.244600200010568Multidisciplinary Team Approach in Prostate-Specific Membrane Antigen Theranostics for Prostate Cancer: A Narrative ReviewMinseok Suh0Gi Jeong Cheon1 Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, KoreaIn managing prostate cancer, the integration of multidisciplinary team (MDT) with prostate-specific membrane antigen (PSMA) theranostics marks a significant advancement, addressing the disease's spectrum from indolent forms to aggressive metastatic stages. MDTs, comprising urology, oncology, radiation oncology, pathology, radiology, and nuclear medicine experts, are pivotal in delivering tailored, evidence-based care, essential for the varied clinical presentations of prostate cancer. The introduction of PSMA-targeted theranostics and PSMA positron emission tomography imaging has impacted the approach to diagnosis and treatment, offering enhanced precision in disease localization and enabling more nuanced management strategies for conditions such as oligometastatic prostate cancer, metastatic hormone-sensitive prostate cancer, and metastatic castration-resistant prostate cancer. The collaborative approach of MDTs in utilizing PSMA-targeted radioligand therapy emphasizes meticulous patient selection, predictive assessment of therapy response, and careful management of therapy-related toxicities. Additionally, recent strategies, including combination therapies from ENZA-P and Lu-PARP trials, show potential for improving treatment efficacy. This unified approach showcases the critical role of MDTs in optimizing treatment outcomes, underscoring the importance of collaboration in advancing the treatment of prostate cancer with PSMAtargeted therapies, thereby setting a new paradigm in personalized prostate cancer management.http://www.e-juo.org/upload/pdf/juo-244600200010.pdfprostatic neoplasmsprostate-specific membrane antigenmultidisciplinary teamtheranostics |
| spellingShingle | Minseok Suh Gi Jeong Cheon Multidisciplinary Team Approach in Prostate-Specific Membrane Antigen Theranostics for Prostate Cancer: A Narrative Review Journal of Urologic Oncology prostatic neoplasms prostate-specific membrane antigen multidisciplinary team theranostics |
| title | Multidisciplinary Team Approach in Prostate-Specific Membrane Antigen Theranostics for Prostate Cancer: A Narrative Review |
| title_full | Multidisciplinary Team Approach in Prostate-Specific Membrane Antigen Theranostics for Prostate Cancer: A Narrative Review |
| title_fullStr | Multidisciplinary Team Approach in Prostate-Specific Membrane Antigen Theranostics for Prostate Cancer: A Narrative Review |
| title_full_unstemmed | Multidisciplinary Team Approach in Prostate-Specific Membrane Antigen Theranostics for Prostate Cancer: A Narrative Review |
| title_short | Multidisciplinary Team Approach in Prostate-Specific Membrane Antigen Theranostics for Prostate Cancer: A Narrative Review |
| title_sort | multidisciplinary team approach in prostate specific membrane antigen theranostics for prostate cancer a narrative review |
| topic | prostatic neoplasms prostate-specific membrane antigen multidisciplinary team theranostics |
| url | http://www.e-juo.org/upload/pdf/juo-244600200010.pdf |
| work_keys_str_mv | AT minseoksuh multidisciplinaryteamapproachinprostatespecificmembraneantigentheranosticsforprostatecanceranarrativereview AT gijeongcheon multidisciplinaryteamapproachinprostatespecificmembraneantigentheranosticsforprostatecanceranarrativereview |