Single-cell analysis reveals tumour size as a key driver of immune cell profile alterations in primary breast tumours and corresponding lymph nodes

Single-cell analysis reveals tumour size as a key driver of immune cell profile alterations in primary breast tumours and corresponding lymph nodes

Abstract Background At diagnosis, 30–40% of women with breast cancer have metastases in sentinel (SN) or axillary lymph nodes (ALN). Nodal status is a strong prognostic factor and guides treatment decisions. Immune checkpoint inhibition has shown some efficacy, which can increase in the neoadjuvant...

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Main Authors: Marit Otterlei Fjørtoft, Øystein Garred, Ole Christian Lingjærde, Karin Teien Lande, Lars Ottestad, Inger Riise Bergheim, OSBREAC, Jon Lømo, Colin LaMont, June Helen Myklebust, Hege Russnes, Kanutte Huse, Inga Hansine Rye
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:BJC Reports
Online Access:https://doi.org/10.1038/s44276-025-00152-3
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