Timing Mechanisms for Circadian Seizures
For centuries, epileptic seizures have been noticed to recur with temporal regularity, suggesting that an underlying biological rhythm may play a crucial role in their timing. In this review, we propose to adopt the framework of chronobiology to study the circadian timing of seizures. We first revie...
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| Language: | English |
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MDPI AG
2024-10-01
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| Series: | Clocks & Sleep |
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| Online Access: | https://www.mdpi.com/2624-5175/6/4/40 |
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| _version_ | 1850040938237263872 |
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| author | Kristina Slabeva Maxime O. Baud |
| author_facet | Kristina Slabeva Maxime O. Baud |
| author_sort | Kristina Slabeva |
| collection | DOAJ |
| description | For centuries, epileptic seizures have been noticed to recur with temporal regularity, suggesting that an underlying biological rhythm may play a crucial role in their timing. In this review, we propose to adopt the framework of chronobiology to study the circadian timing of seizures. We first review observations made on seizure timing in patients with epilepsy and animal models of the disorder. We then present the existing chronobiology paradigm to disentangle intertwined circadian and sleep–wake timing mechanisms. In the light of this framework, we review the existing evidence for specific timing mechanisms in specific epilepsy syndromes and highlight that current knowledge is far from sufficient. We propose that individual seizure chronotypes may result from an interplay between independent timing mechanisms. We conclude with a research agenda to help solve the urgency of ticking seizures. |
| format | Article |
| id | doaj-art-4219c649cb8f4dbd9ff3db6ffda92d82 |
| institution | DOAJ |
| issn | 2624-5175 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clocks & Sleep |
| spelling | doaj-art-4219c649cb8f4dbd9ff3db6ffda92d822025-08-20T02:55:56ZengMDPI AGClocks & Sleep2624-51752024-10-016458960110.3390/clockssleep6040040Timing Mechanisms for Circadian SeizuresKristina Slabeva0Maxime O. Baud1Zentrum für Experimentelle Neurologie, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, SwitzerlandZentrum für Experimentelle Neurologie, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, SwitzerlandFor centuries, epileptic seizures have been noticed to recur with temporal regularity, suggesting that an underlying biological rhythm may play a crucial role in their timing. In this review, we propose to adopt the framework of chronobiology to study the circadian timing of seizures. We first review observations made on seizure timing in patients with epilepsy and animal models of the disorder. We then present the existing chronobiology paradigm to disentangle intertwined circadian and sleep–wake timing mechanisms. In the light of this framework, we review the existing evidence for specific timing mechanisms in specific epilepsy syndromes and highlight that current knowledge is far from sufficient. We propose that individual seizure chronotypes may result from an interplay between independent timing mechanisms. We conclude with a research agenda to help solve the urgency of ticking seizures.https://www.mdpi.com/2624-5175/6/4/40circadiansleepepileptic seizures |
| spellingShingle | Kristina Slabeva Maxime O. Baud Timing Mechanisms for Circadian Seizures Clocks & Sleep circadian sleep epileptic seizures |
| title | Timing Mechanisms for Circadian Seizures |
| title_full | Timing Mechanisms for Circadian Seizures |
| title_fullStr | Timing Mechanisms for Circadian Seizures |
| title_full_unstemmed | Timing Mechanisms for Circadian Seizures |
| title_short | Timing Mechanisms for Circadian Seizures |
| title_sort | timing mechanisms for circadian seizures |
| topic | circadian sleep epileptic seizures |
| url | https://www.mdpi.com/2624-5175/6/4/40 |
| work_keys_str_mv | AT kristinaslabeva timingmechanismsforcircadianseizures AT maximeobaud timingmechanismsforcircadianseizures |