A methylation clock model of mild SARS‐CoV‐2 infection provides insight into immune dysregulation

A methylation clock model of mild SARS‐CoV‐2 infection provides insight into immune dysregulation

Abstract DNA methylation comprises a cumulative record of lifetime exposures superimposed on genetically determined markers. Little is known about methylation dynamics in humans following an acute perturbation, such as infection. We characterized the temporal trajectory of blood epigenetic remodelin...

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Main Authors: Weiguang Mao, Clare M Miller, Venugopalan D Nair, Yongchao Ge, Mary Anne S Amper, Antonio Cappuccio, Mary‐Catherine George, Carl W Goforth, Kristy Guevara, Nada Marjanovic, German Nudelman, Hanna Pincas, Irene Ramos, Rachel S G Sealfon, Alessandra Soares‐Schanoski, Sindhu Vangeti, Mital Vasoya, Dawn L Weir, Elena Zaslavsky, Biobank Team, Vanessa Barcessat, Kevin Tuballes, Diane Marie Del Valle, Kai Nie, Hui Xie, Grace Chung, Manishkumar Patel, Jocelyn Harris, Kimberly Argueta, Jacques Fehr, Barr Gruberg, Nicholas Zaki, Seunghee Kim‐Schulze, Sacha Gnjatic, Miriam Merad, Andrew G Letizia, Olga G Troyanskaya, Stuart C Sealfon, Maria Chikina
Format: Article
Language:English
Published: Springer Nature 2023-03-01
Series:Molecular Systems Biology
Subjects:
DNA methylation
machine learning model
SARS‐CoV‐2
temporal dynamics
trained immunity
Online Access:https://doi.org/10.15252/msb.202211361
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