Correlation between microneutralization test and a multiplexed immunoassay for evaluation of monkeypox and vaccinia virus antibodies before and after smallpox vaccination

Correlation between microneutralization test and a multiplexed immunoassay for evaluation of monkeypox and vaccinia virus antibodies before and after smallpox vaccination

IntroductionMonkeypox (mpox), an endemic zoonotic viral disease in Central and Western Africa, gained international attention in 2022 when clade IIb of the Monkeypox virus (MPXV) spread outside Africa, prompting the World Health Organization (WHO) to declare it a Public Health Emergency of Internati...

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Main Authors: Serena Marchi, Giulia Piccini, Edmond J. Remarque, Giulia Roscia, Bianca Semplici, Paolo Cantaloni, Noemi Guerrini, Roberta Zannella, Rosa Coluccio, Linda Benincasa, Niccolò Solfanelli, Claudia Maria Trombetta, Emanuele Montomoli, Alessandro Manenti
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
monkeypox virus
vaccinia virus
binding and neutralizing antibodies
crossreactive antibody response
humoral immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1585284/full
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