The Relationship between Body Mass Index and the Severity of Coronary Artery Disease in Patients Referred for Coronary Angiography
Background and Aim. Obesity is associated with an increased risk of cardiovascular disease and may be associated with more severe coronary artery disease (CAD); however, the relationship between body mass index [BMI (kg/m2)] and CAD severity is uncertain and debatable. The aim of this study was to e...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/5481671 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564679903281152 |
|---|---|
| author | Anne B. Gregory Kendra K. Lester Deborah M. Gregory Laurie K. Twells William K. Midodzi Neil J. Pearce |
| author_facet | Anne B. Gregory Kendra K. Lester Deborah M. Gregory Laurie K. Twells William K. Midodzi Neil J. Pearce |
| author_sort | Anne B. Gregory |
| collection | DOAJ |
| description | Background and Aim. Obesity is associated with an increased risk of cardiovascular disease and may be associated with more severe coronary artery disease (CAD); however, the relationship between body mass index [BMI (kg/m2)] and CAD severity is uncertain and debatable. The aim of this study was to examine the relationship between BMI and angiographic severity of CAD. Methods. Duke Jeopardy Score (DJS), a prognostic tool predictive of 1-year mortality in CAD, was assigned to angiographic data of patients ≥18 years of age (N=8,079). Patients were grouped into 3 BMI categories: normal (18.5–24.9 kg/m2), overweight (25.0–29.9 kg/m2), and obese (≥30 kg/m2); and multivariable adjusted hazard ratios for 1-year all-cause and cardiac-specific mortality were calculated. Results. Cardiac risk factor prevalence (e.g., diabetes, hypertension, and hyperlipidemia) significantly increased with increasing BMI. Unadjusted all-cause and cardiac-specific 1-year mortality tended to rise with incremental increases in DJS, with the exception of DJS 6 (p<0.001). After adjusting for potential confounders, no significant association of BMI and all-cause (HR 0.70, 95% CI .48–1.02) or cardiac-specific (HR 1.11, 95% CI .64–1.92) mortality was found. Conclusions. This study failed to detect an association of BMI with 1-year all-cause or cardiac-specific mortality after adjustment for potential confounding variables. |
| format | Article |
| id | doaj-art-420b2dbff309437498f5721a2618ce56 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-420b2dbff309437498f5721a2618ce562025-02-03T01:10:24ZengWileyCardiology Research and Practice2090-80162090-05972017-01-01201710.1155/2017/54816715481671The Relationship between Body Mass Index and the Severity of Coronary Artery Disease in Patients Referred for Coronary AngiographyAnne B. Gregory0Kendra K. Lester1Deborah M. Gregory2Laurie K. Twells3William K. Midodzi4Neil J. Pearce5Department of Clinical Epidemiology, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, A1B 3V6, CanadaDepartment of Clinical Epidemiology, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, A1B 3V6, CanadaDepartment of Clinical Epidemiology, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, A1B 3V6, CanadaDepartment of Clinical Epidemiology, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, A1B 3V6, CanadaDepartment of Clinical Epidemiology, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, A1B 3V6, CanadaDepartment of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, A1B 3V6, CanadaBackground and Aim. Obesity is associated with an increased risk of cardiovascular disease and may be associated with more severe coronary artery disease (CAD); however, the relationship between body mass index [BMI (kg/m2)] and CAD severity is uncertain and debatable. The aim of this study was to examine the relationship between BMI and angiographic severity of CAD. Methods. Duke Jeopardy Score (DJS), a prognostic tool predictive of 1-year mortality in CAD, was assigned to angiographic data of patients ≥18 years of age (N=8,079). Patients were grouped into 3 BMI categories: normal (18.5–24.9 kg/m2), overweight (25.0–29.9 kg/m2), and obese (≥30 kg/m2); and multivariable adjusted hazard ratios for 1-year all-cause and cardiac-specific mortality were calculated. Results. Cardiac risk factor prevalence (e.g., diabetes, hypertension, and hyperlipidemia) significantly increased with increasing BMI. Unadjusted all-cause and cardiac-specific 1-year mortality tended to rise with incremental increases in DJS, with the exception of DJS 6 (p<0.001). After adjusting for potential confounders, no significant association of BMI and all-cause (HR 0.70, 95% CI .48–1.02) or cardiac-specific (HR 1.11, 95% CI .64–1.92) mortality was found. Conclusions. This study failed to detect an association of BMI with 1-year all-cause or cardiac-specific mortality after adjustment for potential confounding variables.http://dx.doi.org/10.1155/2017/5481671 |
| spellingShingle | Anne B. Gregory Kendra K. Lester Deborah M. Gregory Laurie K. Twells William K. Midodzi Neil J. Pearce The Relationship between Body Mass Index and the Severity of Coronary Artery Disease in Patients Referred for Coronary Angiography Cardiology Research and Practice |
| title | The Relationship between Body Mass Index and the Severity of Coronary Artery Disease in Patients Referred for Coronary Angiography |
| title_full | The Relationship between Body Mass Index and the Severity of Coronary Artery Disease in Patients Referred for Coronary Angiography |
| title_fullStr | The Relationship between Body Mass Index and the Severity of Coronary Artery Disease in Patients Referred for Coronary Angiography |
| title_full_unstemmed | The Relationship between Body Mass Index and the Severity of Coronary Artery Disease in Patients Referred for Coronary Angiography |
| title_short | The Relationship between Body Mass Index and the Severity of Coronary Artery Disease in Patients Referred for Coronary Angiography |
| title_sort | relationship between body mass index and the severity of coronary artery disease in patients referred for coronary angiography |
| url | http://dx.doi.org/10.1155/2017/5481671 |
| work_keys_str_mv | AT annebgregory therelationshipbetweenbodymassindexandtheseverityofcoronaryarterydiseaseinpatientsreferredforcoronaryangiography AT kendraklester therelationshipbetweenbodymassindexandtheseverityofcoronaryarterydiseaseinpatientsreferredforcoronaryangiography AT deborahmgregory therelationshipbetweenbodymassindexandtheseverityofcoronaryarterydiseaseinpatientsreferredforcoronaryangiography AT lauriektwells therelationshipbetweenbodymassindexandtheseverityofcoronaryarterydiseaseinpatientsreferredforcoronaryangiography AT williamkmidodzi therelationshipbetweenbodymassindexandtheseverityofcoronaryarterydiseaseinpatientsreferredforcoronaryangiography AT neiljpearce therelationshipbetweenbodymassindexandtheseverityofcoronaryarterydiseaseinpatientsreferredforcoronaryangiography AT annebgregory relationshipbetweenbodymassindexandtheseverityofcoronaryarterydiseaseinpatientsreferredforcoronaryangiography AT kendraklester relationshipbetweenbodymassindexandtheseverityofcoronaryarterydiseaseinpatientsreferredforcoronaryangiography AT deborahmgregory relationshipbetweenbodymassindexandtheseverityofcoronaryarterydiseaseinpatientsreferredforcoronaryangiography AT lauriektwells relationshipbetweenbodymassindexandtheseverityofcoronaryarterydiseaseinpatientsreferredforcoronaryangiography AT williamkmidodzi relationshipbetweenbodymassindexandtheseverityofcoronaryarterydiseaseinpatientsreferredforcoronaryangiography AT neiljpearce relationshipbetweenbodymassindexandtheseverityofcoronaryarterydiseaseinpatientsreferredforcoronaryangiography |