Giant extrachromosomal element “Inocle” potentially expands the adaptive capacity of the human oral microbiome

Giant extrachromosomal element “Inocle” potentially expands the adaptive capacity of the human oral microbiome

Abstract Survival strategy of bacteria is expanded by extrachromosomal elements (ECEs). However, their genetic diversity and functional roles for adaptability are largely unknown. Here, we discover a novel family of intracellular ECEs using 56 saliva samples by developing an efficient microbial DNA...

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Main Authors: Yuya Kiguchi, Nagisa Hamamoto, Yukie Kashima, Lucky R. Runtuwene, Aya Ishizaka, Yuta Kuze, Tomohiro Enokida, Nobukazu Tanaka, Makoto Tahara, Shun-Ichiro Kageyama, Takao Fujisawa, Riu Yamashita, Akinori Kanai, Josef S. B. Tuda, Taketoshi Mizutani, Yutaka Suzuki
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62406-5
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