Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures

Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures

Abstract Objective Evaluating the efficacy of an opioid antagonist, naloxone (NLX), to reduce the severity of post‐ictal hypoxemia and immobility after focal to bilateral tonic–clonic seizures (FBTCS). Methods ENALEPSY is a double‐blind placebo (PCB)‐controlled trial conducted in patients with focal...

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Main Authors: Sylvain Rheims, Fatima Chorfa, Véronique Michel, Edouard Hirsch, Louis Maillard, Luc Valton, Fabrice Bartolomei, Philippe Derambure, Vincent Navarro, Julien Biberon, Arielle Crespel, Anca Nica, Martine Lemesle Martin, Laure Mazzola, Jerome Petit, Vincent Rossero, Sébastien Boulogne, Mathilde Leclercq, Laurent Bezin, Catherine Mercier, Pascal Roy, Philippe Ryvlin, the ENALEPSY Study Group
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Epilepsia Open
Subjects:
epilepsy
generalized convulsive seizures
naloxone
post‐ictal EEG hypoxemia
post‐ictal immobility
SUDEP
Online Access:https://doi.org/10.1002/epi4.70046
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