Simplified Assessment of the Index of Microvascular Resistance
Background. To validate a simplified invasive method for the calculation of the index of microvascular resistance (IMR). Methods. This is a prospective, single-center study of patients with chronic coronary syndromes presenting with nonobstructive coronary artery disease. IMR was obtained using both...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Interventional Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2021/9971874 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850104713772531712 |
|---|---|
| author | Monika Kodeboina Sakura Nagumo Daniel Munhoz Jeroen Sonck Niya Mileva Emanuele Gallinoro Alessandro Candreva Takuya Mizukami Frederik Van Durme Alex Heyse Eric Wyffels Marc Vanderheyden Emanuele Barbato Jozef Bartunek Bernard De Bruyne Carlos Collet |
| author_facet | Monika Kodeboina Sakura Nagumo Daniel Munhoz Jeroen Sonck Niya Mileva Emanuele Gallinoro Alessandro Candreva Takuya Mizukami Frederik Van Durme Alex Heyse Eric Wyffels Marc Vanderheyden Emanuele Barbato Jozef Bartunek Bernard De Bruyne Carlos Collet |
| author_sort | Monika Kodeboina |
| collection | DOAJ |
| description | Background. To validate a simplified invasive method for the calculation of the index of microvascular resistance (IMR). Methods. This is a prospective, single-center study of patients with chronic coronary syndromes presenting with nonobstructive coronary artery disease. IMR was obtained using both intravenous (IV) adenosine and intracoronary (IC) papaverine. Each IMR measurement was obtained in duplicate. The primary objective was the agreement between IMR acquired using adenosine and papaverine. Secondary objectives include reproducibility of IMR and time required for the IMR measurement. Results. One hundred and sixteen IMR measurements were performed in 29 patients. The mean age was 68.8 ± 7.24 years, and 27.6% was diabetics. IMR values were similar between papaverine and adenosine (17.7 ± 7.26 and 20.1 ± 8.6, p=0.25; Passing-Bablok coefficient A 0.58, 95% CI −2.42 to 3.53; coefficient B 0.90, 95% CI −0.74 to 1.07). The reproducibility of IMR was excellent with both adenosine and papaverine (ICC 0.78, 95% CI 0.63 to 0.88 and ICC 0.93, 95% CI 0.87 to 0.97). The time needed for microvascular assessment was significantly shortened by the use of IC papaverine (3.23 (2.84, 3.78) mins vs. 5.48 (4.94, 7.09) mins, p<0.0001). Conclusion. IMR can be reliably measured using IC papaverine with similar results compared to intravenous infusion of adenosine with increased reproducibility and reduced procedural time. This approach simplifies the invasive assessment of the coronary microcirculation in the catheterization laboratory. |
| format | Article |
| id | doaj-art-41f9f2e7d49d464fabac165efc0be26a |
| institution | DOAJ |
| issn | 0896-4327 1540-8183 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Interventional Cardiology |
| spelling | doaj-art-41f9f2e7d49d464fabac165efc0be26a2025-08-20T02:39:16ZengWileyJournal of Interventional Cardiology0896-43271540-81832021-01-01202110.1155/2021/99718749971874Simplified Assessment of the Index of Microvascular ResistanceMonika Kodeboina0Sakura Nagumo1Daniel Munhoz2Jeroen Sonck3Niya Mileva4Emanuele Gallinoro5Alessandro Candreva6Takuya Mizukami7Frederik Van Durme8Alex Heyse9Eric Wyffels10Marc Vanderheyden11Emanuele Barbato12Jozef Bartunek13Bernard De Bruyne14Carlos Collet15Cardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumCardiovascular Center Aalst, OLV Clinic, Aalst, BelgiumBackground. To validate a simplified invasive method for the calculation of the index of microvascular resistance (IMR). Methods. This is a prospective, single-center study of patients with chronic coronary syndromes presenting with nonobstructive coronary artery disease. IMR was obtained using both intravenous (IV) adenosine and intracoronary (IC) papaverine. Each IMR measurement was obtained in duplicate. The primary objective was the agreement between IMR acquired using adenosine and papaverine. Secondary objectives include reproducibility of IMR and time required for the IMR measurement. Results. One hundred and sixteen IMR measurements were performed in 29 patients. The mean age was 68.8 ± 7.24 years, and 27.6% was diabetics. IMR values were similar between papaverine and adenosine (17.7 ± 7.26 and 20.1 ± 8.6, p=0.25; Passing-Bablok coefficient A 0.58, 95% CI −2.42 to 3.53; coefficient B 0.90, 95% CI −0.74 to 1.07). The reproducibility of IMR was excellent with both adenosine and papaverine (ICC 0.78, 95% CI 0.63 to 0.88 and ICC 0.93, 95% CI 0.87 to 0.97). The time needed for microvascular assessment was significantly shortened by the use of IC papaverine (3.23 (2.84, 3.78) mins vs. 5.48 (4.94, 7.09) mins, p<0.0001). Conclusion. IMR can be reliably measured using IC papaverine with similar results compared to intravenous infusion of adenosine with increased reproducibility and reduced procedural time. This approach simplifies the invasive assessment of the coronary microcirculation in the catheterization laboratory.http://dx.doi.org/10.1155/2021/9971874 |
| spellingShingle | Monika Kodeboina Sakura Nagumo Daniel Munhoz Jeroen Sonck Niya Mileva Emanuele Gallinoro Alessandro Candreva Takuya Mizukami Frederik Van Durme Alex Heyse Eric Wyffels Marc Vanderheyden Emanuele Barbato Jozef Bartunek Bernard De Bruyne Carlos Collet Simplified Assessment of the Index of Microvascular Resistance Journal of Interventional Cardiology |
| title | Simplified Assessment of the Index of Microvascular Resistance |
| title_full | Simplified Assessment of the Index of Microvascular Resistance |
| title_fullStr | Simplified Assessment of the Index of Microvascular Resistance |
| title_full_unstemmed | Simplified Assessment of the Index of Microvascular Resistance |
| title_short | Simplified Assessment of the Index of Microvascular Resistance |
| title_sort | simplified assessment of the index of microvascular resistance |
| url | http://dx.doi.org/10.1155/2021/9971874 |
| work_keys_str_mv | AT monikakodeboina simplifiedassessmentoftheindexofmicrovascularresistance AT sakuranagumo simplifiedassessmentoftheindexofmicrovascularresistance AT danielmunhoz simplifiedassessmentoftheindexofmicrovascularresistance AT jeroensonck simplifiedassessmentoftheindexofmicrovascularresistance AT niyamileva simplifiedassessmentoftheindexofmicrovascularresistance AT emanuelegallinoro simplifiedassessmentoftheindexofmicrovascularresistance AT alessandrocandreva simplifiedassessmentoftheindexofmicrovascularresistance AT takuyamizukami simplifiedassessmentoftheindexofmicrovascularresistance AT frederikvandurme simplifiedassessmentoftheindexofmicrovascularresistance AT alexheyse simplifiedassessmentoftheindexofmicrovascularresistance AT ericwyffels simplifiedassessmentoftheindexofmicrovascularresistance AT marcvanderheyden simplifiedassessmentoftheindexofmicrovascularresistance AT emanuelebarbato simplifiedassessmentoftheindexofmicrovascularresistance AT jozefbartunek simplifiedassessmentoftheindexofmicrovascularresistance AT bernarddebruyne simplifiedassessmentoftheindexofmicrovascularresistance AT carloscollet simplifiedassessmentoftheindexofmicrovascularresistance |