Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions
Abstract Viral infections continue to pose a significant threat to the health of both humans and animals. Currently, live attenuated vaccines (LAVs) remain the most efficacious and widely utilized tool for combating viral infections. Conventional LAVs involve the adaptation of virulent viruses to no...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202407241 |
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| author | Yan‐Dong Tang Yuming Li Xue‐Hui Cai Xin Yin |
| author_facet | Yan‐Dong Tang Yuming Li Xue‐Hui Cai Xin Yin |
| author_sort | Yan‐Dong Tang |
| collection | DOAJ |
| description | Abstract Viral infections continue to pose a significant threat to the health of both humans and animals. Currently, live attenuated vaccines (LAVs) remain the most efficacious and widely utilized tool for combating viral infections. Conventional LAVs involve the adaptation of virulent viruses to novel hosts, cell cultures, or suboptimal environments, resulting in a reduction in pathogenicity while retaining immunogenicity. This process entails directed evolution of the virus to enhance its replication efficiency under these modified conditions. In this review, the development of traditional animal‐adapted and cold‐adapted LAVs is specially discussed. Additionally, the factors that contribute to virus attenuation from a viral lifecycle perspective are summarized. Finally, we propose future directions for next‐generation LAVs. |
| format | Article |
| id | doaj-art-41f789388a744ba7a865e17c29bdfef6 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-41f789388a744ba7a865e17c29bdfef62025-01-20T13:04:18ZengWileyAdvanced Science2198-38442025-01-01123n/an/a10.1002/advs.202407241Viral Live‐Attenuated Vaccines (LAVs): Past and Future DirectionsYan‐Dong Tang0Yuming Li1Xue‐Hui Cai2Xin Yin3State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences Harbin 150069 ChinaSchool of Public Health Shandong First Medical University & Shandong Academy of Medical Sciences Ji'nan 250117 ChinaState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences Harbin 150069 ChinaState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences Harbin 150069 ChinaAbstract Viral infections continue to pose a significant threat to the health of both humans and animals. Currently, live attenuated vaccines (LAVs) remain the most efficacious and widely utilized tool for combating viral infections. Conventional LAVs involve the adaptation of virulent viruses to novel hosts, cell cultures, or suboptimal environments, resulting in a reduction in pathogenicity while retaining immunogenicity. This process entails directed evolution of the virus to enhance its replication efficiency under these modified conditions. In this review, the development of traditional animal‐adapted and cold‐adapted LAVs is specially discussed. Additionally, the factors that contribute to virus attenuation from a viral lifecycle perspective are summarized. Finally, we propose future directions for next‐generation LAVs.https://doi.org/10.1002/advs.202407241adaptationattenuationevolutionlive attenuated vaccines (LAVs)pathogenicity |
| spellingShingle | Yan‐Dong Tang Yuming Li Xue‐Hui Cai Xin Yin Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions Advanced Science adaptation attenuation evolution live attenuated vaccines (LAVs) pathogenicity |
| title | Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions |
| title_full | Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions |
| title_fullStr | Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions |
| title_full_unstemmed | Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions |
| title_short | Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions |
| title_sort | viral live attenuated vaccines lavs past and future directions |
| topic | adaptation attenuation evolution live attenuated vaccines (LAVs) pathogenicity |
| url | https://doi.org/10.1002/advs.202407241 |
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