Lipid Profile and Correlation to Cardiac Risk Factors and Cardiovascular Function in Type 1 Adolescent Diabetics from a Developing Country
Objective. The adverse role of dyslipidemia in predicting cardiovascular outcomes has not been elucidated extensively among type 1 diabetics in the literature. Methods. We assessed dyslipidemia and its correlation to other cardiac risk factors in adolescents with type 1 diabetes. Total thirty type 1...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2014/513460 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849304597399601152 |
|---|---|
| author | Aashima Dabas Sangeeta Yadav V. K. Gupta |
| author_facet | Aashima Dabas Sangeeta Yadav V. K. Gupta |
| author_sort | Aashima Dabas |
| collection | DOAJ |
| description | Objective. The adverse role of dyslipidemia in predicting cardiovascular outcomes has not been elucidated extensively among type 1 diabetics in the literature. Methods. We assessed dyslipidemia and its correlation to other cardiac risk factors in adolescents with type 1 diabetes. Total thirty type 1 adolescent diabetics were evaluated for their metabolic profile, including serum lipids and echocardiography was performed. Results. The average age of the cohort was 14.3 ± 3.09 yr with disease duration of 5.35 ± 2.94 yr. The mean HbA1C was 8.01%. The mean serum cholesterol, LDL, HDL, and triglyceride were normal. Serum cholesterol was high in patients with longer disease duration (P=0.011, r=0.41), high systolic blood pressure (P=0.04, r=0.32), and elevated HbA1C > 8% (P=0.038, r=0.33). Higher lipid values were associated with poorer carotid artery distensibility (P>0.05) and higher carotid artery intimomedial thickness (cIMT) (P<0.05 for cholesterol and LDL). Hyperglycemia adversely affected ejection fractions, though serum lipids did not show any significant effect on left ventricular parameters. Conclusions. Dyslipidemia and hyperglycemia can serve as biomarkers for cardiovascular dysfunction in at-risk adolescents with type 1 diabetes. Carotid artery parameters are adjunctive tools which may be affected early in the course of macrovascular disease. |
| format | Article |
| id | doaj-art-41f6b2eafa274742947144fd1fcc0fcf |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-41f6b2eafa274742947144fd1fcc0fcf2025-08-20T03:55:41ZengWileyInternational Journal of Pediatrics1687-97401687-97592014-01-01201410.1155/2014/513460513460Lipid Profile and Correlation to Cardiac Risk Factors and Cardiovascular Function in Type 1 Adolescent Diabetics from a Developing CountryAashima Dabas0Sangeeta Yadav1V. K. Gupta2Department of Paediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, Bahadur Shah Zafar Marg, New Delhi 110002, IndiaDepartment of Paediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, Bahadur Shah Zafar Marg, New Delhi 110002, IndiaDepartment of Biochemistry, G. B. Pant Hospital, Jawahar Lal Nehru Marg, New Delhi 110002, IndiaObjective. The adverse role of dyslipidemia in predicting cardiovascular outcomes has not been elucidated extensively among type 1 diabetics in the literature. Methods. We assessed dyslipidemia and its correlation to other cardiac risk factors in adolescents with type 1 diabetes. Total thirty type 1 adolescent diabetics were evaluated for their metabolic profile, including serum lipids and echocardiography was performed. Results. The average age of the cohort was 14.3 ± 3.09 yr with disease duration of 5.35 ± 2.94 yr. The mean HbA1C was 8.01%. The mean serum cholesterol, LDL, HDL, and triglyceride were normal. Serum cholesterol was high in patients with longer disease duration (P=0.011, r=0.41), high systolic blood pressure (P=0.04, r=0.32), and elevated HbA1C > 8% (P=0.038, r=0.33). Higher lipid values were associated with poorer carotid artery distensibility (P>0.05) and higher carotid artery intimomedial thickness (cIMT) (P<0.05 for cholesterol and LDL). Hyperglycemia adversely affected ejection fractions, though serum lipids did not show any significant effect on left ventricular parameters. Conclusions. Dyslipidemia and hyperglycemia can serve as biomarkers for cardiovascular dysfunction in at-risk adolescents with type 1 diabetes. Carotid artery parameters are adjunctive tools which may be affected early in the course of macrovascular disease.http://dx.doi.org/10.1155/2014/513460 |
| spellingShingle | Aashima Dabas Sangeeta Yadav V. K. Gupta Lipid Profile and Correlation to Cardiac Risk Factors and Cardiovascular Function in Type 1 Adolescent Diabetics from a Developing Country International Journal of Pediatrics |
| title | Lipid Profile and Correlation to Cardiac Risk Factors and Cardiovascular Function in Type 1 Adolescent Diabetics from a Developing Country |
| title_full | Lipid Profile and Correlation to Cardiac Risk Factors and Cardiovascular Function in Type 1 Adolescent Diabetics from a Developing Country |
| title_fullStr | Lipid Profile and Correlation to Cardiac Risk Factors and Cardiovascular Function in Type 1 Adolescent Diabetics from a Developing Country |
| title_full_unstemmed | Lipid Profile and Correlation to Cardiac Risk Factors and Cardiovascular Function in Type 1 Adolescent Diabetics from a Developing Country |
| title_short | Lipid Profile and Correlation to Cardiac Risk Factors and Cardiovascular Function in Type 1 Adolescent Diabetics from a Developing Country |
| title_sort | lipid profile and correlation to cardiac risk factors and cardiovascular function in type 1 adolescent diabetics from a developing country |
| url | http://dx.doi.org/10.1155/2014/513460 |
| work_keys_str_mv | AT aashimadabas lipidprofileandcorrelationtocardiacriskfactorsandcardiovascularfunctionintype1adolescentdiabeticsfromadevelopingcountry AT sangeetayadav lipidprofileandcorrelationtocardiacriskfactorsandcardiovascularfunctionintype1adolescentdiabeticsfromadevelopingcountry AT vkgupta lipidprofileandcorrelationtocardiacriskfactorsandcardiovascularfunctionintype1adolescentdiabeticsfromadevelopingcountry |