Systemic Immune-Inflammation Index: A Promising, Non-Invasive Biomarker for Crohn’s Disease Activity and Severity Assessment
Yu’en Deng,1,2 Ting Fu,1 Dian Gao,3 Jianming Zhou,1 Xinhua Nie,1 Fenfen Wang,1 Qiongfang Yu1 1Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2Huankui Academy, Jiangxi Medical C...
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Dove Medical Press
2025-01-01
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| author | Deng Y Fu T Gao D Zhou J Nie X Wang F Yu Q |
| author_facet | Deng Y Fu T Gao D Zhou J Nie X Wang F Yu Q |
| author_sort | Deng Y |
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| description | Yu’en Deng,1,2 Ting Fu,1 Dian Gao,3 Jianming Zhou,1 Xinhua Nie,1 Fenfen Wang,1 Qiongfang Yu1 1Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2Huankui Academy, Jiangxi Medical College, Nanchang University, Nanchang, 330031, People’s Republic of China; 3Department of Pathogen Biology and Immunology, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of ChinaCorrespondence: Qiongfang Yu, Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Minde Road 1, Nanchang, 330006, People’s Republic of China, Email qiongfangyu@yeah.netPurpose: Crohn’s disease (CD) is a chronic inflammatory disorder with periods of exacerbation and remission. We aim to evaluate the systemic immune-inflammation index (SII) as a prognostic biomarker in CD and its utility in predicting disease activity and severity.Patients and Methods: This retrospective study analyzed CD patients using the Harvey-Bradshaw index (HBI) for disease stratification and the Simple Endoscopic Score for Crohn’s Disease (SES-CD) for post-treatment evaluation. Data analysis was conducted using R software. Serological indices underwent predictive analysis through the receiver operating characteristic (ROC) curve. The least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression identified independent prognostic factors to construct nomograms. Model validation was performed using the Concordance index (C-index), calibration analysis and decision curve analysis (DCA).Results: In this study, 254 patients with Crohn’s disease (CD) were enrolled, including 171 males and 83 females, with ages ranging from 13 to 74. SII was significantly elevated in active CD (p< 0.001), correlating with disease severity (p< 0.001). Although SII decreased in patients with mucosal healing (p< 0.001), its prognostic accuracy (AUC=0.719) was lower than other biomarkers. However, SII emerged as an independent predictor for CD activity and severity with higher efficacy (AUC=0.774 and 0.807). The CD activity and severity prediction nomograms showed high C-indices (0.8038 and 0.8208), indicating strong predictive performance.Conclusion: SII is a valuable biomarker for assessing CD severity and monitoring mucosal healing post-treatment. The SII-based nomograms offer a reliable model for evaluating CD progression, aiding in personalized treatment approaches and enhancing clinical decision-making. We recommend randomized controlled trials (RCTs) or studies with larger sample sizes to improve the model.Keywords: Crohn’s disease, biomarkers, inflammation, nomograms, disease progression |
| format | Article |
| id | doaj-art-41ed4e8fcbfc466d89edb7852de91942 |
| institution | Kabale University |
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| language | English |
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| spelling | doaj-art-41ed4e8fcbfc466d89edb7852de919422025-01-30T18:07:17ZengDove Medical PressInternational Journal of General Medicine1178-70742025-01-01Volume 1848349699737Systemic Immune-Inflammation Index: A Promising, Non-Invasive Biomarker for Crohn’s Disease Activity and Severity AssessmentDeng YFu TGao DZhou JNie XWang FYu QYu’en Deng,1,2 Ting Fu,1 Dian Gao,3 Jianming Zhou,1 Xinhua Nie,1 Fenfen Wang,1 Qiongfang Yu1 1Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2Huankui Academy, Jiangxi Medical College, Nanchang University, Nanchang, 330031, People’s Republic of China; 3Department of Pathogen Biology and Immunology, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of ChinaCorrespondence: Qiongfang Yu, Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Minde Road 1, Nanchang, 330006, People’s Republic of China, Email qiongfangyu@yeah.netPurpose: Crohn’s disease (CD) is a chronic inflammatory disorder with periods of exacerbation and remission. We aim to evaluate the systemic immune-inflammation index (SII) as a prognostic biomarker in CD and its utility in predicting disease activity and severity.Patients and Methods: This retrospective study analyzed CD patients using the Harvey-Bradshaw index (HBI) for disease stratification and the Simple Endoscopic Score for Crohn’s Disease (SES-CD) for post-treatment evaluation. Data analysis was conducted using R software. Serological indices underwent predictive analysis through the receiver operating characteristic (ROC) curve. The least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression identified independent prognostic factors to construct nomograms. Model validation was performed using the Concordance index (C-index), calibration analysis and decision curve analysis (DCA).Results: In this study, 254 patients with Crohn’s disease (CD) were enrolled, including 171 males and 83 females, with ages ranging from 13 to 74. SII was significantly elevated in active CD (p< 0.001), correlating with disease severity (p< 0.001). Although SII decreased in patients with mucosal healing (p< 0.001), its prognostic accuracy (AUC=0.719) was lower than other biomarkers. However, SII emerged as an independent predictor for CD activity and severity with higher efficacy (AUC=0.774 and 0.807). The CD activity and severity prediction nomograms showed high C-indices (0.8038 and 0.8208), indicating strong predictive performance.Conclusion: SII is a valuable biomarker for assessing CD severity and monitoring mucosal healing post-treatment. The SII-based nomograms offer a reliable model for evaluating CD progression, aiding in personalized treatment approaches and enhancing clinical decision-making. We recommend randomized controlled trials (RCTs) or studies with larger sample sizes to improve the model.Keywords: Crohn’s disease, biomarkers, inflammation, nomograms, disease progressionhttps://www.dovepress.com/systemic-immune-inflammation-index-a-promising-non-invasive-biomarker--peer-reviewed-fulltext-article-IJGMcrohn’s diseasebiomarkersinflammationnomogramsdisease progression. |
| spellingShingle | Deng Y Fu T Gao D Zhou J Nie X Wang F Yu Q Systemic Immune-Inflammation Index: A Promising, Non-Invasive Biomarker for Crohn’s Disease Activity and Severity Assessment International Journal of General Medicine crohn’s disease biomarkers inflammation nomograms disease progression. |
| title | Systemic Immune-Inflammation Index: A Promising, Non-Invasive Biomarker for Crohn’s Disease Activity and Severity Assessment |
| title_full | Systemic Immune-Inflammation Index: A Promising, Non-Invasive Biomarker for Crohn’s Disease Activity and Severity Assessment |
| title_fullStr | Systemic Immune-Inflammation Index: A Promising, Non-Invasive Biomarker for Crohn’s Disease Activity and Severity Assessment |
| title_full_unstemmed | Systemic Immune-Inflammation Index: A Promising, Non-Invasive Biomarker for Crohn’s Disease Activity and Severity Assessment |
| title_short | Systemic Immune-Inflammation Index: A Promising, Non-Invasive Biomarker for Crohn’s Disease Activity and Severity Assessment |
| title_sort | systemic immune inflammation index a promising non invasive biomarker for crohn rsquo s disease activity and severity assessment |
| topic | crohn’s disease biomarkers inflammation nomograms disease progression. |
| url | https://www.dovepress.com/systemic-immune-inflammation-index-a-promising-non-invasive-biomarker--peer-reviewed-fulltext-article-IJGM |
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