Erythrocytapheresis as a strategy to manage anemia and iron overload in nondeletional hemoglobin H disease
Abstract Hemoglobin H (HbH) disease is associated with anemia, ineffective erythropoiesis, and iron overload. We report a case of a patient with HbH/Hb Constant Spring disease, who was maintained on chronic transfusions as an adult due to symptomatic anemia. Over time, he developed iron overload and...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | eJHaem |
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| Online Access: | https://doi.org/10.1002/jha2.1089 |
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| author | Ke Zhang John Bliamptis Janice Park Patricia Kopko Amber P. Sanchez Srila Gopal |
| author_facet | Ke Zhang John Bliamptis Janice Park Patricia Kopko Amber P. Sanchez Srila Gopal |
| author_sort | Ke Zhang |
| collection | DOAJ |
| description | Abstract Hemoglobin H (HbH) disease is associated with anemia, ineffective erythropoiesis, and iron overload. We report a case of a patient with HbH/Hb Constant Spring disease, who was maintained on chronic transfusions as an adult due to symptomatic anemia. Over time, he developed iron overload and was started on chelation therapy but did not have an adequate response to chelation. We then added erythrocytapheresis to chelation therapy and were able to successfully decrease his iron burden while managing his anemia. Therapeutic erythrocytapheresis may be an effective treatment strategy for iron overload in HbH disease that is refractory to chelation. |
| format | Article |
| id | doaj-art-41ec3d3e278047f7972972a274833ca5 |
| institution | DOAJ |
| issn | 2688-6146 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj-art-41ec3d3e278047f7972972a274833ca52025-08-20T02:46:50ZengWileyeJHaem2688-61462025-02-0161n/an/a10.1002/jha2.1089Erythrocytapheresis as a strategy to manage anemia and iron overload in nondeletional hemoglobin H diseaseKe Zhang0John Bliamptis1Janice Park2Patricia Kopko3Amber P. Sanchez4Srila Gopal5Department of Internal Medicine Capital Medical University Beijing ChinaDivision of Internal Medicine University of California San Diego La Jolla California USADivision of Nephrology University of California San Diego La Jolla California USADivision of Pathology University of California San Diego La Jolla California USADivision of Nephrology University of California San Diego La Jolla California USADivision of Hematology University of California San Diego La Jolla California USAAbstract Hemoglobin H (HbH) disease is associated with anemia, ineffective erythropoiesis, and iron overload. We report a case of a patient with HbH/Hb Constant Spring disease, who was maintained on chronic transfusions as an adult due to symptomatic anemia. Over time, he developed iron overload and was started on chelation therapy but did not have an adequate response to chelation. We then added erythrocytapheresis to chelation therapy and were able to successfully decrease his iron burden while managing his anemia. Therapeutic erythrocytapheresis may be an effective treatment strategy for iron overload in HbH disease that is refractory to chelation.https://doi.org/10.1002/jha2.1089erythrocytapheresisiron overloadthalassemia |
| spellingShingle | Ke Zhang John Bliamptis Janice Park Patricia Kopko Amber P. Sanchez Srila Gopal Erythrocytapheresis as a strategy to manage anemia and iron overload in nondeletional hemoglobin H disease eJHaem erythrocytapheresis iron overload thalassemia |
| title | Erythrocytapheresis as a strategy to manage anemia and iron overload in nondeletional hemoglobin H disease |
| title_full | Erythrocytapheresis as a strategy to manage anemia and iron overload in nondeletional hemoglobin H disease |
| title_fullStr | Erythrocytapheresis as a strategy to manage anemia and iron overload in nondeletional hemoglobin H disease |
| title_full_unstemmed | Erythrocytapheresis as a strategy to manage anemia and iron overload in nondeletional hemoglobin H disease |
| title_short | Erythrocytapheresis as a strategy to manage anemia and iron overload in nondeletional hemoglobin H disease |
| title_sort | erythrocytapheresis as a strategy to manage anemia and iron overload in nondeletional hemoglobin h disease |
| topic | erythrocytapheresis iron overload thalassemia |
| url | https://doi.org/10.1002/jha2.1089 |
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