EVALUATION OF HISTOLOGICAL PARAMETERS IN PATIENTS WITH CLINICAL REMISSION OF ULCERATIVE COLITIS
Goal of the study: to examine histological changes in the mucosa of patients with clinical remission of ulcerative colitis and compare these changes with endoscopic parameters. Methods: 25 patients with clinical remission of ulcerative colitis underwent fibrocolonoscopy with biopsy and histological...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2014-11-01
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| Series: | Acta Biomedica Scientifica |
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| Online Access: | https://www.actabiomedica.ru/jour/article/view/1832 |
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| author | O. B. Shchukina E. A. Kondrashina A. M. Kharitidis A. V. Botina E. A. Markova |
| author_facet | O. B. Shchukina E. A. Kondrashina A. M. Kharitidis A. V. Botina E. A. Markova |
| author_sort | O. B. Shchukina |
| collection | DOAJ |
| description | Goal of the study: to examine histological changes in the mucosa of patients with clinical remission of ulcerative colitis and compare these changes with endoscopic parameters. Methods: 25 patients with clinical remission of ulcerative colitis underwent fibrocolonoscopy with biopsy and histological assessment of disease activity on the Gebos scale. Due to limited number of observations, it was possible to identify comparable study and control groups only for two parameters: increased eosinophil count and increased density of infiltrate in the mucosa. Results of the study: erosions, cryptitis, hyperplasia of lymphoid structures and infiltration of the intestinal mucosa with neutrophilic leukocyte often observed in the presence of increased eosinophil count in the mucosa and/or increased density of the cellular infiltrate. Conclusion: increased eosinophil count and/or increased density of the cellular infiltrate in the mucosa often accompanied by other signs of lack of the mucosa healing. Confirmation of complete remission of the disease requires histological control for exclusion of the inflammation signs. |
| format | Article |
| id | doaj-art-41eb4e9150544590a90349f6ea6bf8ff |
| institution | Kabale University |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| publishDate | 2014-11-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj-art-41eb4e9150544590a90349f6ea6bf8ff2025-08-20T03:56:54ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962014-11-010639431778EVALUATION OF HISTOLOGICAL PARAMETERS IN PATIENTS WITH CLINICAL REMISSION OF ULCERATIVE COLITISO. B. Shchukina0E. A. Kondrashina1A. M. Kharitidis2A. V. Botina3E. A. Markova4Mechnikov North-Western State UniversityMechnikov North-Western State UniversityCity Center of Diagnostics and Treatment of Colon Inflammatory Disorders at City Clinical Hospital N 31First St. Petersburg State Medical UniversityCity Clinical Hospital N 31Goal of the study: to examine histological changes in the mucosa of patients with clinical remission of ulcerative colitis and compare these changes with endoscopic parameters. Methods: 25 patients with clinical remission of ulcerative colitis underwent fibrocolonoscopy with biopsy and histological assessment of disease activity on the Gebos scale. Due to limited number of observations, it was possible to identify comparable study and control groups only for two parameters: increased eosinophil count and increased density of infiltrate in the mucosa. Results of the study: erosions, cryptitis, hyperplasia of lymphoid structures and infiltration of the intestinal mucosa with neutrophilic leukocyte often observed in the presence of increased eosinophil count in the mucosa and/or increased density of the cellular infiltrate. Conclusion: increased eosinophil count and/or increased density of the cellular infiltrate in the mucosa often accompanied by other signs of lack of the mucosa healing. Confirmation of complete remission of the disease requires histological control for exclusion of the inflammation signs.https://www.actabiomedica.ru/jour/article/view/1832ulcerative colitismucosal healingeosinophilsincreased density of infiltrate |
| spellingShingle | O. B. Shchukina E. A. Kondrashina A. M. Kharitidis A. V. Botina E. A. Markova EVALUATION OF HISTOLOGICAL PARAMETERS IN PATIENTS WITH CLINICAL REMISSION OF ULCERATIVE COLITIS Acta Biomedica Scientifica ulcerative colitis mucosal healing eosinophils increased density of infiltrate |
| title | EVALUATION OF HISTOLOGICAL PARAMETERS IN PATIENTS WITH CLINICAL REMISSION OF ULCERATIVE COLITIS |
| title_full | EVALUATION OF HISTOLOGICAL PARAMETERS IN PATIENTS WITH CLINICAL REMISSION OF ULCERATIVE COLITIS |
| title_fullStr | EVALUATION OF HISTOLOGICAL PARAMETERS IN PATIENTS WITH CLINICAL REMISSION OF ULCERATIVE COLITIS |
| title_full_unstemmed | EVALUATION OF HISTOLOGICAL PARAMETERS IN PATIENTS WITH CLINICAL REMISSION OF ULCERATIVE COLITIS |
| title_short | EVALUATION OF HISTOLOGICAL PARAMETERS IN PATIENTS WITH CLINICAL REMISSION OF ULCERATIVE COLITIS |
| title_sort | evaluation of histological parameters in patients with clinical remission of ulcerative colitis |
| topic | ulcerative colitis mucosal healing eosinophils increased density of infiltrate |
| url | https://www.actabiomedica.ru/jour/article/view/1832 |
| work_keys_str_mv | AT obshchukina evaluationofhistologicalparametersinpatientswithclinicalremissionofulcerativecolitis AT eakondrashina evaluationofhistologicalparametersinpatientswithclinicalremissionofulcerativecolitis AT amkharitidis evaluationofhistologicalparametersinpatientswithclinicalremissionofulcerativecolitis AT avbotina evaluationofhistologicalparametersinpatientswithclinicalremissionofulcerativecolitis AT eamarkova evaluationofhistologicalparametersinpatientswithclinicalremissionofulcerativecolitis |