A wheat CC-NBS-LRR protein Ym1 confers WYMV resistance by recognizing viral coat protein
Abstract Ym1 is the most widely utilized gene for wheat yellow mosaic virus (WYMV) disease control in worldwide wheat breeding. Here, we successfully isolated the responsible gene for Ym1. It encodes a typical CC-NBS-LRR type R protein, which is specifically expressed in root and induced upon WYMV i...
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Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58816-0 |
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| author | Yiming Chen Dehui Kong Zongkuan Wang Jiaqian Liu Linghan Wang Keli Dai Jialun Ji Wei Chen Xiong Tang Mingxing Wen Xu Zhang Huajian Zhang Chengzhi Jiao Li Sun Haiyan Wang Xingru Fei Hong Guo Bingjian Sun Xiaorong Tao Wei Wang Jian Yang Xiue Wang Jin Xiao |
| author_facet | Yiming Chen Dehui Kong Zongkuan Wang Jiaqian Liu Linghan Wang Keli Dai Jialun Ji Wei Chen Xiong Tang Mingxing Wen Xu Zhang Huajian Zhang Chengzhi Jiao Li Sun Haiyan Wang Xingru Fei Hong Guo Bingjian Sun Xiaorong Tao Wei Wang Jian Yang Xiue Wang Jin Xiao |
| author_sort | Yiming Chen |
| collection | DOAJ |
| description | Abstract Ym1 is the most widely utilized gene for wheat yellow mosaic virus (WYMV) disease control in worldwide wheat breeding. Here, we successfully isolated the responsible gene for Ym1. It encodes a typical CC-NBS-LRR type R protein, which is specifically expressed in root and induced upon WYMV infection. Ym1-mediated WYMV resistance is likely achieved by blocking viral transmission from the root cortex into steles, thereby preventing systemic movement to aerial tissues. Ym1 CC domain is essential for triggering cell death. Ym1 specifically interacts with WYMV coat protein, and this interaction leads to nucleocytoplasmic redistribution, a process for transitioning Ym1 from an auto-inhibited to an activated state. The activation subsequently elicits hypersensitive responses and establishes WYMV resistance. Ym1 is likely introgressed from the sub-genome Xn or Xc of polyploid Aegilops species. The findings highlight an exogenous-introgressed and root-specifically expressed R gene that confers WYMV resistance by recognizing the viral component. |
| format | Article |
| id | doaj-art-41ea20becdff4fa3bd4329ec774cfc00 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| series | Nature Communications |
| spelling | doaj-art-41ea20becdff4fa3bd4329ec774cfc002025-08-20T02:28:09ZengNature PortfolioNature Communications2041-17232025-04-0116111610.1038/s41467-025-58816-0A wheat CC-NBS-LRR protein Ym1 confers WYMV resistance by recognizing viral coat proteinYiming Chen0Dehui Kong1Zongkuan Wang2Jiaqian Liu3Linghan Wang4Keli Dai5Jialun Ji6Wei Chen7Xiong Tang8Mingxing Wen9Xu Zhang10Huajian Zhang11Chengzhi Jiao12Li Sun13Haiyan Wang14Xingru Fei15Hong Guo16Bingjian Sun17Xiaorong Tao18Wei Wang19Jian Yang20Xiue Wang21Jin Xiao22National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPInstitute of Plant Virology, Ningbo UniversityNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing UniversityNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPYandu District Agricultural Science Research InstituteYandu District Agricultural Science Research InstituteCollege of Plant Protection, Henan Agricultural UniversityDepartment of Plant Pathology, Nanjing Agricultural UniversityNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPInstitute of Plant Virology, Ningbo UniversityNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPNational Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCPAbstract Ym1 is the most widely utilized gene for wheat yellow mosaic virus (WYMV) disease control in worldwide wheat breeding. Here, we successfully isolated the responsible gene for Ym1. It encodes a typical CC-NBS-LRR type R protein, which is specifically expressed in root and induced upon WYMV infection. Ym1-mediated WYMV resistance is likely achieved by blocking viral transmission from the root cortex into steles, thereby preventing systemic movement to aerial tissues. Ym1 CC domain is essential for triggering cell death. Ym1 specifically interacts with WYMV coat protein, and this interaction leads to nucleocytoplasmic redistribution, a process for transitioning Ym1 from an auto-inhibited to an activated state. The activation subsequently elicits hypersensitive responses and establishes WYMV resistance. Ym1 is likely introgressed from the sub-genome Xn or Xc of polyploid Aegilops species. The findings highlight an exogenous-introgressed and root-specifically expressed R gene that confers WYMV resistance by recognizing the viral component.https://doi.org/10.1038/s41467-025-58816-0 |
| spellingShingle | Yiming Chen Dehui Kong Zongkuan Wang Jiaqian Liu Linghan Wang Keli Dai Jialun Ji Wei Chen Xiong Tang Mingxing Wen Xu Zhang Huajian Zhang Chengzhi Jiao Li Sun Haiyan Wang Xingru Fei Hong Guo Bingjian Sun Xiaorong Tao Wei Wang Jian Yang Xiue Wang Jin Xiao A wheat CC-NBS-LRR protein Ym1 confers WYMV resistance by recognizing viral coat protein Nature Communications |
| title | A wheat CC-NBS-LRR protein Ym1 confers WYMV resistance by recognizing viral coat protein |
| title_full | A wheat CC-NBS-LRR protein Ym1 confers WYMV resistance by recognizing viral coat protein |
| title_fullStr | A wheat CC-NBS-LRR protein Ym1 confers WYMV resistance by recognizing viral coat protein |
| title_full_unstemmed | A wheat CC-NBS-LRR protein Ym1 confers WYMV resistance by recognizing viral coat protein |
| title_short | A wheat CC-NBS-LRR protein Ym1 confers WYMV resistance by recognizing viral coat protein |
| title_sort | wheat cc nbs lrr protein ym1 confers wymv resistance by recognizing viral coat protein |
| url | https://doi.org/10.1038/s41467-025-58816-0 |
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