Development of an eco-friendly UPLC method for simultaneous quantification of six selected phosphodiesterase-5 inhibitors and serotonin reuptake inhibitors in pharmaceutical formulations and adulterated food using a quality by design approach

Development of an eco-friendly UPLC method for simultaneous quantification of six selected phosphodiesterase-5 inhibitors and serotonin reuptake inhibitors in pharmaceutical formulations and adulterated food using a quality by design approach

Abstract This study introduces an innovative, environmentally sustainable ultra-performance liquid chromatography (UPLC) method with UV detection for the concurrent quantification of six clinically relevant pharmaceuticals—vardenafil, avanafil, sildenafil, dapoxetine, duloxetine, and tadalafil—frequ...

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Bibliographic Details
Main Authors: Heba Abdel-Hafeez Mohamed, Mohamed Badawi NourEldin, Asmaa Ahmed El-Zaher, Sally Tarek Mahmoud
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Green chemistry
Quality by design
UPLC
Erectile dysfunction drug
Powder and dosage separation
Online Access:https://doi.org/10.1186/s43094-025-00824-4
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