Inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesis
Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) mainly expresses type-2 endotype, featuring eosinophils as a main player in the inflammatory process. Prolonged eosinophilia in the tissues of asthma and CRSwNP patients has been associated with structural changes, leading to fixed airflow obst...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1568541/full |
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| author | Kantapat Simmalee Kantapat Simmalee Putthapoom Lumjiaktase Theerasuk Kawamatawong Amir Guemari Valérian Dormoy Joana Vitte Joana Vitte |
| author_facet | Kantapat Simmalee Kantapat Simmalee Putthapoom Lumjiaktase Theerasuk Kawamatawong Amir Guemari Valérian Dormoy Joana Vitte Joana Vitte |
| author_sort | Kantapat Simmalee |
| collection | DOAJ |
| description | Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) mainly expresses type-2 endotype, featuring eosinophils as a main player in the inflammatory process. Prolonged eosinophilia in the tissues of asthma and CRSwNP patients has been associated with structural changes, leading to fixed airflow obstruction in asthma and nasal polyposis in CRSwNP. This suggests that eosinophils may belong to different subgroups playing distinct roles in pathogenesis. Recent studies highlight the roles of inflammatory eosinophils (iEOS) in driving inflammation and tissue damage, whereas tissue-resident eosinophils (rEOS) maintain homeostasis and tissue repair in the airway. Therefore, understanding both roles of eosinophil subpopulations is crucial for better CRSwNP management, including enhancing the diagnosis accuracy, predicting recurrence, and optimizing treatment strategies. |
| format | Article |
| id | doaj-art-41e1b3ca9c01410d824c295db3c7c0e1 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-41e1b3ca9c01410d824c295db3c7c0e12025-08-20T02:09:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15685411568541Inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesisKantapat Simmalee0Kantapat Simmalee1Putthapoom Lumjiaktase2Theerasuk Kawamatawong3Amir Guemari4Valérian Dormoy5Joana Vitte6Joana Vitte7Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandUniversité de Reims Champagne-Ardenne, Institut national de la santé et de la recherche médicale (Inserm) Unité Mixte de Recherche (UMR)-S 1250 Pulmonary Pathologies and Cell Plasticity (P3Cell), Reims, FranceDepartment of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandImmunology Laboratory, University Hospital of Reims, University of Reims Champagne-Ardenne, Reims, FranceUniversité de Reims Champagne-Ardenne, Institut national de la santé et de la recherche médicale (Inserm) Unité Mixte de Recherche (UMR)-S 1250 Pulmonary Pathologies and Cell Plasticity (P3Cell), Reims, FranceUniversité de Reims Champagne-Ardenne, Institut national de la santé et de la recherche médicale (Inserm) Unité Mixte de Recherche (UMR)-S 1250 Pulmonary Pathologies and Cell Plasticity (P3Cell), Reims, FranceImmunology Laboratory, University Hospital of Reims, University of Reims Champagne-Ardenne, Reims, FranceChronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) mainly expresses type-2 endotype, featuring eosinophils as a main player in the inflammatory process. Prolonged eosinophilia in the tissues of asthma and CRSwNP patients has been associated with structural changes, leading to fixed airflow obstruction in asthma and nasal polyposis in CRSwNP. This suggests that eosinophils may belong to different subgroups playing distinct roles in pathogenesis. Recent studies highlight the roles of inflammatory eosinophils (iEOS) in driving inflammation and tissue damage, whereas tissue-resident eosinophils (rEOS) maintain homeostasis and tissue repair in the airway. Therefore, understanding both roles of eosinophil subpopulations is crucial for better CRSwNP management, including enhancing the diagnosis accuracy, predicting recurrence, and optimizing treatment strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1568541/fullchronic rhinosinusitis with nasal polypseosinophileosinophil subpopulationsinflammatory eosinophilsresident eosinophils |
| spellingShingle | Kantapat Simmalee Kantapat Simmalee Putthapoom Lumjiaktase Theerasuk Kawamatawong Amir Guemari Valérian Dormoy Joana Vitte Joana Vitte Inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesis Frontiers in Immunology chronic rhinosinusitis with nasal polyps eosinophil eosinophil subpopulations inflammatory eosinophils resident eosinophils |
| title | Inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesis |
| title_full | Inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesis |
| title_fullStr | Inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesis |
| title_full_unstemmed | Inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesis |
| title_short | Inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesis |
| title_sort | inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesis |
| topic | chronic rhinosinusitis with nasal polyps eosinophil eosinophil subpopulations inflammatory eosinophils resident eosinophils |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1568541/full |
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