The Link Between Physical Function, β-Amyloid, and Cognitive Aging in Women
This study aimed to examine associations between functional capacity (FC), brain β-amyloid (Aβ) burden, and longitudinal cognitive performance. Data from 89 cognitively normal women (70.0 ± 2.7 years) in the Women’s Healthy Ageing Project cohort were analyzed. FC was assessed using the timed up and...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/15/9/5210 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849312873726083072 |
|---|---|
| author | Raquel Pedrero-Chamizo Cassandra Szoeke |
| author_facet | Raquel Pedrero-Chamizo Cassandra Szoeke |
| author_sort | Raquel Pedrero-Chamizo |
| collection | DOAJ |
| description | This study aimed to examine associations between functional capacity (FC), brain β-amyloid (Aβ) burden, and longitudinal cognitive performance. Data from 89 cognitively normal women (70.0 ± 2.7 years) in the Women’s Healthy Ageing Project cohort were analyzed. FC was assessed using the timed up and go (TUG) test and the Aβ burden was quantified via a F-18 Florbetaben PET scan with Standardized Uptake Value Ratio (SUVR). Cognition was evaluated longitudinally using the Preclinical Alzheimer Cognitive Composite (PACC) over 3.9 ± 2.6 years. Multiple linear regression, mediation analysis, and linear mixed-effects models were applied. Baseline Aβ burden and years of education were associated with cognitive performance two to six years later, while the TUG performance was associated with cognitive outcomes at two years. Aβ burden was found to mediate the relationship between FC and cognition over time. A significant three-way interaction (TUG × SUVR × time) was observed, indicating that declines in the TUG performance over time were exclusively associated with steeper cognitive decline among women with elevated Aβ burden (SUVR ≥ 1.42). These findings suggest that maintaining functional mobility may be particularly relevant for women with increased Aβ burden and support future research targeting early motor-cognitive markers. |
| format | Article |
| id | doaj-art-41df0664a2d74ef78503b9e936aa7bab |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-41df0664a2d74ef78503b9e936aa7bab2025-08-20T03:52:56ZengMDPI AGApplied Sciences2076-34172025-05-01159521010.3390/app15095210The Link Between Physical Function, β-Amyloid, and Cognitive Aging in WomenRaquel Pedrero-Chamizo0Cassandra Szoeke1ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, SpainCentre for Research Implementation and Translation, Monash University, Clayton, VIC 3168, AustraliaThis study aimed to examine associations between functional capacity (FC), brain β-amyloid (Aβ) burden, and longitudinal cognitive performance. Data from 89 cognitively normal women (70.0 ± 2.7 years) in the Women’s Healthy Ageing Project cohort were analyzed. FC was assessed using the timed up and go (TUG) test and the Aβ burden was quantified via a F-18 Florbetaben PET scan with Standardized Uptake Value Ratio (SUVR). Cognition was evaluated longitudinally using the Preclinical Alzheimer Cognitive Composite (PACC) over 3.9 ± 2.6 years. Multiple linear regression, mediation analysis, and linear mixed-effects models were applied. Baseline Aβ burden and years of education were associated with cognitive performance two to six years later, while the TUG performance was associated with cognitive outcomes at two years. Aβ burden was found to mediate the relationship between FC and cognition over time. A significant three-way interaction (TUG × SUVR × time) was observed, indicating that declines in the TUG performance over time were exclusively associated with steeper cognitive decline among women with elevated Aβ burden (SUVR ≥ 1.42). These findings suggest that maintaining functional mobility may be particularly relevant for women with increased Aβ burden and support future research targeting early motor-cognitive markers.https://www.mdpi.com/2076-3417/15/9/5210Alzheimer’s diseaseamyloidPETtimed up and gocognitionsuccessful aging |
| spellingShingle | Raquel Pedrero-Chamizo Cassandra Szoeke The Link Between Physical Function, β-Amyloid, and Cognitive Aging in Women Applied Sciences Alzheimer’s disease amyloid PET timed up and go cognition successful aging |
| title | The Link Between Physical Function, β-Amyloid, and Cognitive Aging in Women |
| title_full | The Link Between Physical Function, β-Amyloid, and Cognitive Aging in Women |
| title_fullStr | The Link Between Physical Function, β-Amyloid, and Cognitive Aging in Women |
| title_full_unstemmed | The Link Between Physical Function, β-Amyloid, and Cognitive Aging in Women |
| title_short | The Link Between Physical Function, β-Amyloid, and Cognitive Aging in Women |
| title_sort | link between physical function β amyloid and cognitive aging in women |
| topic | Alzheimer’s disease amyloid PET timed up and go cognition successful aging |
| url | https://www.mdpi.com/2076-3417/15/9/5210 |
| work_keys_str_mv | AT raquelpedrerochamizo thelinkbetweenphysicalfunctionbamyloidandcognitiveaginginwomen AT cassandraszoeke thelinkbetweenphysicalfunctionbamyloidandcognitiveaginginwomen AT raquelpedrerochamizo linkbetweenphysicalfunctionbamyloidandcognitiveaginginwomen AT cassandraszoeke linkbetweenphysicalfunctionbamyloidandcognitiveaginginwomen |