Grip strength as a surrogate measure of strength, functional, and metabolic parameter increases in breast cancer survivors undergoing an exercise regimen
Abstract Grip strength, a surrogate for quantifying strength, correlates with function and longevity. However, this relationship is less clear in women with breast cancer. 138 women undergoing oncologic treatment for breast cancer were enrolled across three institutional review board-approved protoc...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-00867-w |
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| author | Colin E. Champ Chris Peluso Christie Hilton Jared Rosenberg Rhyeli Krause Alexander K. Diaz David J. Carpenter |
| author_facet | Colin E. Champ Chris Peluso Christie Hilton Jared Rosenberg Rhyeli Krause Alexander K. Diaz David J. Carpenter |
| author_sort | Colin E. Champ |
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| description | Abstract Grip strength, a surrogate for quantifying strength, correlates with function and longevity. However, this relationship is less clear in women with breast cancer. 138 women undergoing oncologic treatment for breast cancer were enrolled across three institutional review board-approved protocols with three months of resistance training with pre and post assessment of body composition, phase angle, functional movement screen (FMS), balance, weight lifted (load), quality of life, activity levels, and hand grip strength. Significant increases in maximum, minimum, and mean grip strength were seen. Mean grip strength increased by 12.6% and 3.5 kg. Right/left (R/L) mismatch significantly decreased from baseline to post-intervention (13.3 to 8.7%). On univariable analysis, greater baseline mean grip strength was associated with younger age, greater baseline FMS, composite load lifted, activity levels, and decreased R/L balance mismatch. On multivariable analysis, greater mean grip strength was independently associated with greater baseline mobility and composite load lifted. Baseline mean grip strength was associated with baseline lower bodyfat percentage and greater muscle mass, whole body phase angle, and resting metabolic rate (all significant on multivariable analysis, R2 = 0.247). Grip strength may be a valuable surrogate biomarker within breast cancer survivorship care, particularly in resource-limited settings. |
| format | Article |
| id | doaj-art-41d841a91107404ebc4d153cc6a2d4fa |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-41d841a91107404ebc4d153cc6a2d4fa2025-08-20T02:15:12ZengNature PortfolioScientific Reports2045-23222025-05-011511710.1038/s41598-025-00867-wGrip strength as a surrogate measure of strength, functional, and metabolic parameter increases in breast cancer survivors undergoing an exercise regimenColin E. Champ0Chris Peluso1Christie Hilton2Jared Rosenberg3Rhyeli Krause4Alexander K. Diaz5David J. Carpenter6Allegheny Health Network Cancer Institute Exercise Oncology and Resiliency CenterDepartment of Radiation Oncology, Allegheny Health NetworkDepartment of Medical Oncology, Allegheny Health NetworkKinesiology Department, State University of New York College at CortlandAllegheny Health Network Cancer Institute Exercise Oncology and Resiliency CenterDepartment of Radiation Oncology, Murray-Calloway County HospitalDepartment of Radiation Oncology, Wellstar Paulding HospitalAbstract Grip strength, a surrogate for quantifying strength, correlates with function and longevity. However, this relationship is less clear in women with breast cancer. 138 women undergoing oncologic treatment for breast cancer were enrolled across three institutional review board-approved protocols with three months of resistance training with pre and post assessment of body composition, phase angle, functional movement screen (FMS), balance, weight lifted (load), quality of life, activity levels, and hand grip strength. Significant increases in maximum, minimum, and mean grip strength were seen. Mean grip strength increased by 12.6% and 3.5 kg. Right/left (R/L) mismatch significantly decreased from baseline to post-intervention (13.3 to 8.7%). On univariable analysis, greater baseline mean grip strength was associated with younger age, greater baseline FMS, composite load lifted, activity levels, and decreased R/L balance mismatch. On multivariable analysis, greater mean grip strength was independently associated with greater baseline mobility and composite load lifted. Baseline mean grip strength was associated with baseline lower bodyfat percentage and greater muscle mass, whole body phase angle, and resting metabolic rate (all significant on multivariable analysis, R2 = 0.247). Grip strength may be a valuable surrogate biomarker within breast cancer survivorship care, particularly in resource-limited settings.https://doi.org/10.1038/s41598-025-00867-wGrip strengthBreast cancerResistance trainingExercise scienceBody composition |
| spellingShingle | Colin E. Champ Chris Peluso Christie Hilton Jared Rosenberg Rhyeli Krause Alexander K. Diaz David J. Carpenter Grip strength as a surrogate measure of strength, functional, and metabolic parameter increases in breast cancer survivors undergoing an exercise regimen Scientific Reports Grip strength Breast cancer Resistance training Exercise science Body composition |
| title | Grip strength as a surrogate measure of strength, functional, and metabolic parameter increases in breast cancer survivors undergoing an exercise regimen |
| title_full | Grip strength as a surrogate measure of strength, functional, and metabolic parameter increases in breast cancer survivors undergoing an exercise regimen |
| title_fullStr | Grip strength as a surrogate measure of strength, functional, and metabolic parameter increases in breast cancer survivors undergoing an exercise regimen |
| title_full_unstemmed | Grip strength as a surrogate measure of strength, functional, and metabolic parameter increases in breast cancer survivors undergoing an exercise regimen |
| title_short | Grip strength as a surrogate measure of strength, functional, and metabolic parameter increases in breast cancer survivors undergoing an exercise regimen |
| title_sort | grip strength as a surrogate measure of strength functional and metabolic parameter increases in breast cancer survivors undergoing an exercise regimen |
| topic | Grip strength Breast cancer Resistance training Exercise science Body composition |
| url | https://doi.org/10.1038/s41598-025-00867-w |
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