Differential metabolic pathways underlie THC- and CBD-mediated inhibition of B-cell activation in both young and aged mice

Differential metabolic pathways underlie THC- and CBD-mediated inhibition of B-cell activation in both young and aged mice

ObjectiveB lymphocytes play a crucial role in immunity but also contribute to the pathogenesis of various diseases. Cannabis plants produce numerous biologically active compounds, including cannabinoids. The two most studied phytocannabinoids are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD)....

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Bibliographic Details
Main Authors: Zhanna Yekhtin, Dmytro Petukhov, Iman Khuja, Natalya M. Kogan, Reuven Or, Osnat Almogi-Hazan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
B lymphocytes
cannabinoid
Δ9-tetrahydrocannabinol (THC)
cannabidiol (CBD)
immune activation
aged
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605474/full
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