Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer
ABSTRACT The advancements in early stratification and timely evaluation of therapeutic effects have revolutionized the ability to assess curative outcomes promptly. The separation between diagnosis/treatment and timely assessment of treatment response, along with delays in evaluating therapy efficac...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Exploration |
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| Online Access: | https://doi.org/10.1002/EXP.20240037 |
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| author | Qinrui Fu |
| author_facet | Qinrui Fu |
| author_sort | Qinrui Fu |
| collection | DOAJ |
| description | ABSTRACT The advancements in early stratification and timely evaluation of therapeutic effects have revolutionized the ability to assess curative outcomes promptly. The separation between diagnosis/treatment and timely assessment of treatment response, along with delays in evaluating therapy efficacy, are significant contributors to treatment failures. Traditional approaches for evaluating curative effects face challenges posed by tumor heterogeneity and resistance, making it challenging to determine the effectiveness of a given therapeutic regimen at an early stage in clinical practice. However, molecular imaging using activatable probes has overcome these obstacles and transformed the field by shifting focus towards developing functional probes for visualizing tumors as well as enabling early stratification or timely evaluation of therapy effects. In this article, we emphasize the importance of diverse activatable molecular imaging probes and provide insights into early stratification or timely evaluation of various therapies’ effects. Finally, we discuss the challenges faced in this field and propose future research directions. |
| format | Article |
| id | doaj-art-41d64fc2573b4b72b3d1dce33115afd2 |
| institution | DOAJ |
| issn | 2766-8509 2766-2098 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Exploration |
| spelling | doaj-art-41d64fc2573b4b72b3d1dce33115afd22025-08-20T03:22:03ZengWileyExploration2766-85092766-20982025-06-0153n/an/a10.1002/EXP.20240037Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in CancerQinrui Fu0Key Laboratory of Maternal & Fetal Medicine of National Health Commission of China Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University Jinan ChinaABSTRACT The advancements in early stratification and timely evaluation of therapeutic effects have revolutionized the ability to assess curative outcomes promptly. The separation between diagnosis/treatment and timely assessment of treatment response, along with delays in evaluating therapy efficacy, are significant contributors to treatment failures. Traditional approaches for evaluating curative effects face challenges posed by tumor heterogeneity and resistance, making it challenging to determine the effectiveness of a given therapeutic regimen at an early stage in clinical practice. However, molecular imaging using activatable probes has overcome these obstacles and transformed the field by shifting focus towards developing functional probes for visualizing tumors as well as enabling early stratification or timely evaluation of therapy effects. In this article, we emphasize the importance of diverse activatable molecular imaging probes and provide insights into early stratification or timely evaluation of various therapies’ effects. Finally, we discuss the challenges faced in this field and propose future research directions.https://doi.org/10.1002/EXP.20240037activatable probebiomarkerearly stratificationmolecular imagingtherapy effecttimely evaluation |
| spellingShingle | Qinrui Fu Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer Exploration activatable probe biomarker early stratification molecular imaging therapy effect timely evaluation |
| title | Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer |
| title_full | Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer |
| title_fullStr | Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer |
| title_full_unstemmed | Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer |
| title_short | Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer |
| title_sort | harnessing biomarker activatable probes for early stratification and timely assessment of therapeutic efficacy in cancer |
| topic | activatable probe biomarker early stratification molecular imaging therapy effect timely evaluation |
| url | https://doi.org/10.1002/EXP.20240037 |
| work_keys_str_mv | AT qinruifu harnessingbiomarkeractivatableprobesforearlystratificationandtimelyassessmentoftherapeuticefficacyincancer |