Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach

Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach

BackgroundProstate cancer (PCa) is one of the prevalent malignant tumors among men. It can progress to castration-resistant prostate cancer (CRPC), which is significantly more challenging to treat. Saikosaponin A (SSA), a triterpenoid saponin extracted from the genus Bupleurum, exerts numerous pharm...

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Bibliographic Details
Main Authors: Genbao Zhu, Zhiming Jiang, Niuping Zhu, Donghui Wang, Tianpeng Guo, Yiqing Meng, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
Saikosaponin A
prostate cancer
network pharmacology
molecular docking
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1530715/full
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