The Recovery of Epidermal Proliferation Pattern in Human Skin Xenograft
Abnormalities in epidermal keratinocyte proliferation are a characteristic feature of a range of dermatological conditions. These include hyperproliferative states in psoriasis and dermatitis as well as hypoproliferative states in chronic wounds. This emphasises the importance of investigating the p...
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| Format: | Article |
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MDPI AG
2025-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/6/448 |
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| author | Olga Cherkashina Alexandra Tsitrina Danila Abolin Elena Morgun Anastasiya Kosykh Marat Sabirov Ekaterina Vorotelyak Ekaterina Kalabusheva |
| author_facet | Olga Cherkashina Alexandra Tsitrina Danila Abolin Elena Morgun Anastasiya Kosykh Marat Sabirov Ekaterina Vorotelyak Ekaterina Kalabusheva |
| author_sort | Olga Cherkashina |
| collection | DOAJ |
| description | Abnormalities in epidermal keratinocyte proliferation are a characteristic feature of a range of dermatological conditions. These include hyperproliferative states in psoriasis and dermatitis as well as hypoproliferative states in chronic wounds. This emphasises the importance of investigating the proliferation kinetics under conditions of healthy skin and identifying the key regulators of epidermal homeostasis, maintenance, and recovery following wound healing. Animal models contribute to our understanding of human epidermal self-renewal. Human skin xenografting overcomes the ethical limitations of studying human skin during regeneration. The application of this approach has allowed for the identification of a single population of stem cells and both slowly and rapidly cycling progenitors within the epidermal basal layer and the mapping of their location in relation to rete ridges and hair follicles. Furthermore, we have traced the dynamics of the proliferation pattern reorganization that occurs during epidermal regeneration, underlining the role of YAP activity in epidermal relief formation. |
| format | Article |
| id | doaj-art-41cfa06d33314df9bab5cb7d5b2a2138 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-41cfa06d33314df9bab5cb7d5b2a21382025-08-20T03:43:15ZengMDPI AGCells2073-44092025-03-0114644810.3390/cells14060448The Recovery of Epidermal Proliferation Pattern in Human Skin XenograftOlga Cherkashina0Alexandra Tsitrina1Danila Abolin2Elena Morgun3Anastasiya Kosykh4Marat Sabirov5Ekaterina Vorotelyak6Ekaterina Kalabusheva7Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, RussiaIlse Katz Institute of Nanoscale Science, Ben Gurion University of the Negev, Beer Sheva 8410501, IsraelKoltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, RussiaKoltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, RussiaCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, 117997 Moscow, RussiaKoltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, RussiaKoltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, RussiaKoltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, RussiaAbnormalities in epidermal keratinocyte proliferation are a characteristic feature of a range of dermatological conditions. These include hyperproliferative states in psoriasis and dermatitis as well as hypoproliferative states in chronic wounds. This emphasises the importance of investigating the proliferation kinetics under conditions of healthy skin and identifying the key regulators of epidermal homeostasis, maintenance, and recovery following wound healing. Animal models contribute to our understanding of human epidermal self-renewal. Human skin xenografting overcomes the ethical limitations of studying human skin during regeneration. The application of this approach has allowed for the identification of a single population of stem cells and both slowly and rapidly cycling progenitors within the epidermal basal layer and the mapping of their location in relation to rete ridges and hair follicles. Furthermore, we have traced the dynamics of the proliferation pattern reorganization that occurs during epidermal regeneration, underlining the role of YAP activity in epidermal relief formation.https://www.mdpi.com/2073-4409/14/6/448keratinocyte proliferationskin regenerationskin stem cellshuman skin xenograft |
| spellingShingle | Olga Cherkashina Alexandra Tsitrina Danila Abolin Elena Morgun Anastasiya Kosykh Marat Sabirov Ekaterina Vorotelyak Ekaterina Kalabusheva The Recovery of Epidermal Proliferation Pattern in Human Skin Xenograft Cells keratinocyte proliferation skin regeneration skin stem cells human skin xenograft |
| title | The Recovery of Epidermal Proliferation Pattern in Human Skin Xenograft |
| title_full | The Recovery of Epidermal Proliferation Pattern in Human Skin Xenograft |
| title_fullStr | The Recovery of Epidermal Proliferation Pattern in Human Skin Xenograft |
| title_full_unstemmed | The Recovery of Epidermal Proliferation Pattern in Human Skin Xenograft |
| title_short | The Recovery of Epidermal Proliferation Pattern in Human Skin Xenograft |
| title_sort | recovery of epidermal proliferation pattern in human skin xenograft |
| topic | keratinocyte proliferation skin regeneration skin stem cells human skin xenograft |
| url | https://www.mdpi.com/2073-4409/14/6/448 |
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