Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin
Background. Pneumococcal infection being one of the dominant causes of acute respiratory diseases and exacerbation of chronic ones is a serious problem for human health and society. The flood in the Amur river basin in the summer of 2013 created a special zone and risk conditions for the formation o...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2019/5467275 |
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| author | Aleksandr G. Chuchalin Gennadiy G. Onishchenko Victor P. Kolosov Olga P. Kurganova Tatiana A. Zaitseva Leonid G. Manakov Galina N. Kholodok Juliy M. Perelman Roman S. Kozlov Natalia M. Ivakhnishina Olga E. Trotsenko Albina P. Bondarenko |
| author_facet | Aleksandr G. Chuchalin Gennadiy G. Onishchenko Victor P. Kolosov Olga P. Kurganova Tatiana A. Zaitseva Leonid G. Manakov Galina N. Kholodok Juliy M. Perelman Roman S. Kozlov Natalia M. Ivakhnishina Olga E. Trotsenko Albina P. Bondarenko |
| author_sort | Aleksandr G. Chuchalin |
| collection | DOAJ |
| description | Background. Pneumococcal infection being one of the dominant causes of acute respiratory diseases and exacerbation of chronic ones is a serious problem for human health and society. The flood in the Amur river basin in the summer of 2013 created a special zone and risk conditions for the formation of respiratory pathology in the Far-Eastern region of Russia. We aimed to give clinical and epidemiological assessment of the effectiveness of vaccination programs of respiratory viral and pneumococcal infections and generalization of regional experience in the organization of a set of measures aimed at their prevention in the postflood period in the Far-Eastern region. Methods. The monitoring program includes children aged 2 to 5 years in the amount of 4988 with risk factors for pneumococcal infection. The pneumococcal conjugate vaccine Prevenar-13 was used for immunization. Data on the incidence of ARVI and pneumonia in children in pre- and postvaccination periods were to be recorded. The indicators and special criteria were used to assess the effectiveness of vaccination. To study the circulation of serovariants of pneumococcus in inflammatory diseases of the respiratory tract and nasopharyngeal carrier, bacteriological and molecular genetic methods (RT-PCR in the mode of multiprime detection) were used. Results. Differences in the frequency and range of serovariants of circulating isolates of pneumococcus in the postvaccinal period and in unvaccinated children, elimination of a number of serotypes, and appearance of circulation of nonvaccinated strains were revealed. The incidence of acute respiratory diseases and pneumonia among the vaccinated population for 2 years in the region decreased by 2.5 times. The coefficient of effectiveness of vaccination according to the indicator of morbidity of children with pneumonia reaches 75-100% with direct dependence on the age of children (r=0.98). Conclusion. Comparative statistical analysis revealed a high degree of effectiveness of regional programs with the methods of immunoprophylaxis of pneumococcal infections. |
| format | Article |
| id | doaj-art-41cb09b45e8544808b52b197cf466786 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-41cb09b45e8544808b52b197cf4667862025-02-03T05:50:52ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982019-01-01201910.1155/2019/54672755467275Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River BasinAleksandr G. Chuchalin0Gennadiy G. Onishchenko1Victor P. Kolosov2Olga P. Kurganova3Tatiana A. Zaitseva4Leonid G. Manakov5Galina N. Kholodok6Juliy M. Perelman7Roman S. Kozlov8Natalia M. Ivakhnishina9Olga E. Trotsenko10Albina P. Bondarenko11Department of Hospital Therapy, Pediatric Faculty, Pirogov Russian National Research Medical University, Moscow 117997, RussiaRussian Academy of Sciences, Moscow 119991, RussiaLaboratory of Prophylaxis of Nonspecific Pulmonary Diseases, Far Eastern Scientific Center of Physiology and Pathology of Respiration, Blagoveshchensk 675000, RussiaThe Board of the Federal Service for Surveillance in Protection of Consumer Rights and Human Well-Being in the Amur Region, Blagoveshchensk 675002, RussiaThe Board of the Federal Service for Surveillance in Protection of Consumer Rights and Human Well-Being in Khabarovsk Territory, Khabarovsk 680009, RussiaLaboratory of Prophylaxis of Nonspecific Pulmonary Diseases, Far Eastern Scientific Center of Physiology and Pathology of Respiration, Blagoveshchensk 675000, RussiaResearch Institute of Protection of Maternity and Childhood, Far Eastern Scientific Center of Physiology and Pathology of Respiration, Khabarovsk 680022, RussiaLaboratory of Prophylaxis of Nonspecific Pulmonary Diseases, Far Eastern Scientific Center of Physiology and Pathology of Respiration, Blagoveshchensk 675000, RussiaThe Smolensk State Medical University, Smolensk 214019, RussiaResearch Institute of Protection of Maternity and Childhood, Far Eastern Scientific Center of Physiology and Pathology of Respiration, Khabarovsk 680022, RussiaThe Khabarovsk Research Institute of Epidemiology and Microbiology, Khabarovsk 680610, RussiaThe Khabarovsk Research Institute of Epidemiology and Microbiology, Khabarovsk 680610, RussiaBackground. Pneumococcal infection being one of the dominant causes of acute respiratory diseases and exacerbation of chronic ones is a serious problem for human health and society. The flood in the Amur river basin in the summer of 2013 created a special zone and risk conditions for the formation of respiratory pathology in the Far-Eastern region of Russia. We aimed to give clinical and epidemiological assessment of the effectiveness of vaccination programs of respiratory viral and pneumococcal infections and generalization of regional experience in the organization of a set of measures aimed at their prevention in the postflood period in the Far-Eastern region. Methods. The monitoring program includes children aged 2 to 5 years in the amount of 4988 with risk factors for pneumococcal infection. The pneumococcal conjugate vaccine Prevenar-13 was used for immunization. Data on the incidence of ARVI and pneumonia in children in pre- and postvaccination periods were to be recorded. The indicators and special criteria were used to assess the effectiveness of vaccination. To study the circulation of serovariants of pneumococcus in inflammatory diseases of the respiratory tract and nasopharyngeal carrier, bacteriological and molecular genetic methods (RT-PCR in the mode of multiprime detection) were used. Results. Differences in the frequency and range of serovariants of circulating isolates of pneumococcus in the postvaccinal period and in unvaccinated children, elimination of a number of serotypes, and appearance of circulation of nonvaccinated strains were revealed. The incidence of acute respiratory diseases and pneumonia among the vaccinated population for 2 years in the region decreased by 2.5 times. The coefficient of effectiveness of vaccination according to the indicator of morbidity of children with pneumonia reaches 75-100% with direct dependence on the age of children (r=0.98). Conclusion. Comparative statistical analysis revealed a high degree of effectiveness of regional programs with the methods of immunoprophylaxis of pneumococcal infections.http://dx.doi.org/10.1155/2019/5467275 |
| spellingShingle | Aleksandr G. Chuchalin Gennadiy G. Onishchenko Victor P. Kolosov Olga P. Kurganova Tatiana A. Zaitseva Leonid G. Manakov Galina N. Kholodok Juliy M. Perelman Roman S. Kozlov Natalia M. Ivakhnishina Olga E. Trotsenko Albina P. Bondarenko Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin Interdisciplinary Perspectives on Infectious Diseases |
| title | Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin |
| title_full | Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin |
| title_fullStr | Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin |
| title_full_unstemmed | Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin |
| title_short | Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin |
| title_sort | vaccine prophylaxis of pneumococcal infections in children under conditions of severe flood in the amur river basin |
| url | http://dx.doi.org/10.1155/2019/5467275 |
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