Vitamin D May not be Crucial: Association between Serum Vitamin D Level and Pregnancy-Induced Hypertension-A Meta-Analysis
Background: The association between vitamin D and pregnancy-induced hypertension (PIH) remains contentious. The aim of our study was to evaluate the existence of an association between serum vitamin D levels and the incidence of PIH....
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IMR Press
2024-09-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/51/9/10.31083/j.ceog5109207 |
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| author | Changxing Cui Xiaoyan Huang Yuanqing Cui Shaochang Jiang Xiaoyan Yao Xuelong Li |
| author_facet | Changxing Cui Xiaoyan Huang Yuanqing Cui Shaochang Jiang Xiaoyan Yao Xuelong Li |
| author_sort | Changxing Cui |
| collection | DOAJ |
| description | Background: The association between vitamin D and pregnancy-induced hypertension (PIH) remains contentious. The aim of our study was to evaluate the existence of an association between serum vitamin D levels and the incidence of PIH. Methods: We conducted a literature search in PubMed, the Cochrane Library, and Embase databases in June 2024 using the following search terms: 25-hydroxyvitamin D (25(OH)D), Vitamin D, 1,25(OH)2D, VD, 1,25-dihydroxyvitamin D or 25(OH)D, combined with PIH. Two reviewers independently screened the literature based on inclusion and exclusion criteria. Data were then extracted and assessed for quality. Comparisons were made between the highest and lowest categories of serum vitamin D levels. Relative risks (RRs) and 95% confidence intervals (CIs), adjusted for multivariable effects, were pooled using a random-effects model. A two-stage dose-response meta-analysis was used to evaluate the trends. Results: 17 studies met the inclusion criteria. Of these, 11 prospective studies investigated the relationship between vitamin D levels and gestational hypertension, involving 8834 events and 17,104 participants. The results showed that vitamin D was only marginally associated with hypertensive disorders in pregnancy (summary RR = 0.99; 95% CI: 0.97–1.02; I2 = 67.5%; p = 0.001). However, 6 case-control studies investigated the relationship between vitamin D levels and gestational hypertension, involving 80,814 events and 330,254 participants. The results showed that vitamin D is not associated with pregnancy hypertensive disorders (summary RR = 1.09; 95% CI: 0.84–1.41; I2 = 75.4%; p = 0.001). In the subgroup analysis, the pooled effect of 25-hydroxyvitamin D (25(OH)D) showed a slight association with gestational hypertension (pooled RR = 0.99; 95% CI: 0.96–1.02; I2 = 72.6%; p = 0.000). The dose-response analysis showed that increasing vitamin D doses are marginally associated with a decrease in the incidence rate. Conclusions: Our research suggests that the risk of PIH may not be related to the vitamin D levels. Our research supports the hypothesis that gestational hypertension may not be associated with low levels of vitamin D, indicating that the role of vitamin D may not be significant. |
| format | Article |
| id | doaj-art-41c60c8cdf384c478546626ae8e2eda2 |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-41c60c8cdf384c478546626ae8e2eda22025-08-20T03:55:40ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-09-0151920710.31083/j.ceog5109207S0390-6663(24)02442-4Vitamin D May not be Crucial: Association between Serum Vitamin D Level and Pregnancy-Induced Hypertension-A Meta-AnalysisChangxing Cui0Xiaoyan Huang1Yuanqing Cui2Shaochang Jiang3Xiaoyan Yao4Xuelong Li5Department of Nursing, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, 264000 Yantai, Shandong, ChinaDepartment of Nursing, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, 264000 Yantai, Shandong, ChinaDepartment of Internal Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, 264000 Yantai, Shandong, ChinaDepartment of Internal Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, 264000 Yantai, Shandong, ChinaDepartment of Internal Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, 264000 Yantai, Shandong, ChinaDepartment of Clinical Nutrition, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, 264000 Yantai, Shandong, ChinaBackground: The association between vitamin D and pregnancy-induced hypertension (PIH) remains contentious. The aim of our study was to evaluate the existence of an association between serum vitamin D levels and the incidence of PIH. Methods: We conducted a literature search in PubMed, the Cochrane Library, and Embase databases in June 2024 using the following search terms: 25-hydroxyvitamin D (25(OH)D), Vitamin D, 1,25(OH)2D, VD, 1,25-dihydroxyvitamin D or 25(OH)D, combined with PIH. Two reviewers independently screened the literature based on inclusion and exclusion criteria. Data were then extracted and assessed for quality. Comparisons were made between the highest and lowest categories of serum vitamin D levels. Relative risks (RRs) and 95% confidence intervals (CIs), adjusted for multivariable effects, were pooled using a random-effects model. A two-stage dose-response meta-analysis was used to evaluate the trends. Results: 17 studies met the inclusion criteria. Of these, 11 prospective studies investigated the relationship between vitamin D levels and gestational hypertension, involving 8834 events and 17,104 participants. The results showed that vitamin D was only marginally associated with hypertensive disorders in pregnancy (summary RR = 0.99; 95% CI: 0.97–1.02; I2 = 67.5%; p = 0.001). However, 6 case-control studies investigated the relationship between vitamin D levels and gestational hypertension, involving 80,814 events and 330,254 participants. The results showed that vitamin D is not associated with pregnancy hypertensive disorders (summary RR = 1.09; 95% CI: 0.84–1.41; I2 = 75.4%; p = 0.001). In the subgroup analysis, the pooled effect of 25-hydroxyvitamin D (25(OH)D) showed a slight association with gestational hypertension (pooled RR = 0.99; 95% CI: 0.96–1.02; I2 = 72.6%; p = 0.000). The dose-response analysis showed that increasing vitamin D doses are marginally associated with a decrease in the incidence rate. Conclusions: Our research suggests that the risk of PIH may not be related to the vitamin D levels. Our research supports the hypothesis that gestational hypertension may not be associated with low levels of vitamin D, indicating that the role of vitamin D may not be significant.https://www.imrpress.com/journal/CEOG/51/9/10.31083/j.ceog5109207pregnancy-induced hypertensionvitamin dmeta-analysis |
| spellingShingle | Changxing Cui Xiaoyan Huang Yuanqing Cui Shaochang Jiang Xiaoyan Yao Xuelong Li Vitamin D May not be Crucial: Association between Serum Vitamin D Level and Pregnancy-Induced Hypertension-A Meta-Analysis Clinical and Experimental Obstetrics & Gynecology pregnancy-induced hypertension vitamin d meta-analysis |
| title | Vitamin D May not be Crucial: Association between Serum Vitamin D Level and Pregnancy-Induced Hypertension-A Meta-Analysis |
| title_full | Vitamin D May not be Crucial: Association between Serum Vitamin D Level and Pregnancy-Induced Hypertension-A Meta-Analysis |
| title_fullStr | Vitamin D May not be Crucial: Association between Serum Vitamin D Level and Pregnancy-Induced Hypertension-A Meta-Analysis |
| title_full_unstemmed | Vitamin D May not be Crucial: Association between Serum Vitamin D Level and Pregnancy-Induced Hypertension-A Meta-Analysis |
| title_short | Vitamin D May not be Crucial: Association between Serum Vitamin D Level and Pregnancy-Induced Hypertension-A Meta-Analysis |
| title_sort | vitamin d may not be crucial association between serum vitamin d level and pregnancy induced hypertension a meta analysis |
| topic | pregnancy-induced hypertension vitamin d meta-analysis |
| url | https://www.imrpress.com/journal/CEOG/51/9/10.31083/j.ceog5109207 |
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