Risk factors for early radiation-induced heart damage in patients undergoing pulmonary SBRT
Abstract Background Stereotactic body radiotherapy (SBRT) is superior to conventional radiotherapy for the treatment of lung tumors but can lead to radiation-induced heart damage (RIHD). Its risk factors have not been clarified. The purpose of our study was to determine the risk factors for early RI...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-06-01
|
| Series: | Echo Research and Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s44156-025-00076-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849434129134780416 |
|---|---|
| author | Tingcui Li Dan Zhu Ming Cui |
| author_facet | Tingcui Li Dan Zhu Ming Cui |
| author_sort | Tingcui Li |
| collection | DOAJ |
| description | Abstract Background Stereotactic body radiotherapy (SBRT) is superior to conventional radiotherapy for the treatment of lung tumors but can lead to radiation-induced heart damage (RIHD). Its risk factors have not been clarified. The purpose of our study was to determine the risk factors for early RIHD in patients undergoing pulmonary SBRT. Methods We prospectively included patients who planned to receive pulmonary SBRT at our center from January 2020 to May 2021. Two-dimensional speckle tracking echocardiography was performed within 2 months after radiotherapy. The diagnostic criterion for early RIHD was a decrease in global longitudinal strain by ≥ 15% from baseline. Logistic regression was used to explore the risk factors for early RIHD. Results A total of 108 patients were included in the study. The overall incidence of early RIHD in the cohort was 41.7%. Significant risk factors, including maximum heart dose, anthracycline use and hypertension, were independently associated with early RIHD, with ORs of 1.058 (95% CI: 1.028–1.089; p < 0.001), 3.524 (95% CI: 1.296–9.577; p = 0.014), and 4.284 (95% CI: 1.424–12.890; p = 0.010), respectively. The cutoff of the maximum heart dose was 27.0 Gy in patients who received anthracycline and 29.3 Gy in those who did not. Conclusions Among patients receiving pulmonary SBRT, the maximum heart radiation dose, the use of anthracycline drugs and hypertension are independently associated with the occurrence of early RIHD. These findings could be applied to predict early RIHD and screen for high-risk patients. Individualized cardiac dose limitations may be helpful in improving the long-term prognosis of pulmonary SBRT patients. |
| format | Article |
| id | doaj-art-41c28fa1990646cb9ac63fbfc2362257 |
| institution | Kabale University |
| issn | 2055-0464 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Echo Research and Practice |
| spelling | doaj-art-41c28fa1990646cb9ac63fbfc23622572025-08-20T03:26:47ZengBMCEcho Research and Practice2055-04642025-06-011211910.1186/s44156-025-00076-1Risk factors for early radiation-induced heart damage in patients undergoing pulmonary SBRTTingcui Li0Dan Zhu1Ming Cui2Department of Intensive Care Unit, Peking University Third HospitalDepartment of Cardiology, Peking University Third HospitalDepartment of Cardiology, Peking University Third HospitalAbstract Background Stereotactic body radiotherapy (SBRT) is superior to conventional radiotherapy for the treatment of lung tumors but can lead to radiation-induced heart damage (RIHD). Its risk factors have not been clarified. The purpose of our study was to determine the risk factors for early RIHD in patients undergoing pulmonary SBRT. Methods We prospectively included patients who planned to receive pulmonary SBRT at our center from January 2020 to May 2021. Two-dimensional speckle tracking echocardiography was performed within 2 months after radiotherapy. The diagnostic criterion for early RIHD was a decrease in global longitudinal strain by ≥ 15% from baseline. Logistic regression was used to explore the risk factors for early RIHD. Results A total of 108 patients were included in the study. The overall incidence of early RIHD in the cohort was 41.7%. Significant risk factors, including maximum heart dose, anthracycline use and hypertension, were independently associated with early RIHD, with ORs of 1.058 (95% CI: 1.028–1.089; p < 0.001), 3.524 (95% CI: 1.296–9.577; p = 0.014), and 4.284 (95% CI: 1.424–12.890; p = 0.010), respectively. The cutoff of the maximum heart dose was 27.0 Gy in patients who received anthracycline and 29.3 Gy in those who did not. Conclusions Among patients receiving pulmonary SBRT, the maximum heart radiation dose, the use of anthracycline drugs and hypertension are independently associated with the occurrence of early RIHD. These findings could be applied to predict early RIHD and screen for high-risk patients. Individualized cardiac dose limitations may be helpful in improving the long-term prognosis of pulmonary SBRT patients.https://doi.org/10.1186/s44156-025-00076-1Radiation-induced heart damageCardiotoxicityStereotactic body radiotherapyGlobal longitudinal strainRisk factors |
| spellingShingle | Tingcui Li Dan Zhu Ming Cui Risk factors for early radiation-induced heart damage in patients undergoing pulmonary SBRT Echo Research and Practice Radiation-induced heart damage Cardiotoxicity Stereotactic body radiotherapy Global longitudinal strain Risk factors |
| title | Risk factors for early radiation-induced heart damage in patients undergoing pulmonary SBRT |
| title_full | Risk factors for early radiation-induced heart damage in patients undergoing pulmonary SBRT |
| title_fullStr | Risk factors for early radiation-induced heart damage in patients undergoing pulmonary SBRT |
| title_full_unstemmed | Risk factors for early radiation-induced heart damage in patients undergoing pulmonary SBRT |
| title_short | Risk factors for early radiation-induced heart damage in patients undergoing pulmonary SBRT |
| title_sort | risk factors for early radiation induced heart damage in patients undergoing pulmonary sbrt |
| topic | Radiation-induced heart damage Cardiotoxicity Stereotactic body radiotherapy Global longitudinal strain Risk factors |
| url | https://doi.org/10.1186/s44156-025-00076-1 |
| work_keys_str_mv | AT tingcuili riskfactorsforearlyradiationinducedheartdamageinpatientsundergoingpulmonarysbrt AT danzhu riskfactorsforearlyradiationinducedheartdamageinpatientsundergoingpulmonarysbrt AT mingcui riskfactorsforearlyradiationinducedheartdamageinpatientsundergoingpulmonarysbrt |