Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis−Induced Osteoporosis in Mice
<b>Background:</b> Osteoporosis is frequently observed in patients with chronic pancreatitis, and both conditions are closely associated with systemic metabolic disorders. However, the underlying mechanisms linking chronic pancreatitis and osteoporosis remain unclear. <b>Methods:&l...
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2025-03-01
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| author | Xinlin Liu Fenglin Hu Yunshu Zhang Shurong Ma Haihua Liu Dong Shang Peiyuan Yin |
| author_facet | Xinlin Liu Fenglin Hu Yunshu Zhang Shurong Ma Haihua Liu Dong Shang Peiyuan Yin |
| author_sort | Xinlin Liu |
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| description | <b>Background:</b> Osteoporosis is frequently observed in patients with chronic pancreatitis, and both conditions are closely associated with systemic metabolic disorders. However, the underlying mechanisms linking chronic pancreatitis and osteoporosis remain unclear. <b>Methods:</b> In this study, we utilized high−performance liquid chromatography–mass spectrometry (HPLC−MS) to conduct metabolomics and lipidomics analyses on pancreatic, serum, and other tissues from a mouse model of chronic pancreatitis−induced osteoporosis (CP−OP), with the aim to elucidate the metabolism−related pathogenic mechanisms of CP−OP. <b>Results:</b> We identified over 405 metabolites and 445 lipids, and our findings revealed that several metabolites involving the tricarboxylic acid (TCA) cycle, as well as triacylglycerols and diacylglycerols with higher saturation, were significantly increased in the CP−OP model. In contrast, triglycerides with higher unsaturation were decreased. Differential pathways were enriched in n−3 long−chain polyunsaturated fatty acid metabolism in both pancreatic and bone tissues, and these pathways exhibited positive correlations with bone−related parameters. Furthermore, the modulation of these polyunsaturated fatty acids by Qingyi granules demonstrated significant therapeutic effects on CP−OP, as validated in mouse models. <b>Conclusions:</b> Through the metabolomics approach, we uncovered that disorders in polyunsaturated fatty acids play a critical role in the pathogenesis of CP−OP. This study not only enhances our understanding of the pathogenesis of CP−OP but also highlights the therapeutic potential of targeting polyunsaturated fatty acids as a future intervention strategy for osteoporosis treatment. |
| format | Article |
| id | doaj-art-41c117257a714fb0836a87c79ee28d6d |
| institution | DOAJ |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-41c117257a714fb0836a87c79ee28d6d2025-08-20T02:42:26ZengMDPI AGMetabolites2218-19892025-03-0115317310.3390/metabo15030173Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis−Induced Osteoporosis in MiceXinlin Liu0Fenglin Hu1Yunshu Zhang2Shurong Ma3Haihua Liu4Dong Shang5Peiyuan Yin6Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, ChinaClinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, ChinaClinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, ChinaClinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, ChinaClinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, ChinaClinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, ChinaClinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China<b>Background:</b> Osteoporosis is frequently observed in patients with chronic pancreatitis, and both conditions are closely associated with systemic metabolic disorders. However, the underlying mechanisms linking chronic pancreatitis and osteoporosis remain unclear. <b>Methods:</b> In this study, we utilized high−performance liquid chromatography–mass spectrometry (HPLC−MS) to conduct metabolomics and lipidomics analyses on pancreatic, serum, and other tissues from a mouse model of chronic pancreatitis−induced osteoporosis (CP−OP), with the aim to elucidate the metabolism−related pathogenic mechanisms of CP−OP. <b>Results:</b> We identified over 405 metabolites and 445 lipids, and our findings revealed that several metabolites involving the tricarboxylic acid (TCA) cycle, as well as triacylglycerols and diacylglycerols with higher saturation, were significantly increased in the CP−OP model. In contrast, triglycerides with higher unsaturation were decreased. Differential pathways were enriched in n−3 long−chain polyunsaturated fatty acid metabolism in both pancreatic and bone tissues, and these pathways exhibited positive correlations with bone−related parameters. Furthermore, the modulation of these polyunsaturated fatty acids by Qingyi granules demonstrated significant therapeutic effects on CP−OP, as validated in mouse models. <b>Conclusions:</b> Through the metabolomics approach, we uncovered that disorders in polyunsaturated fatty acids play a critical role in the pathogenesis of CP−OP. This study not only enhances our understanding of the pathogenesis of CP−OP but also highlights the therapeutic potential of targeting polyunsaturated fatty acids as a future intervention strategy for osteoporosis treatment.https://www.mdpi.com/2218-1989/15/3/173chronic pancreatitisosteoporosismetabolomicslipidomics |
| spellingShingle | Xinlin Liu Fenglin Hu Yunshu Zhang Shurong Ma Haihua Liu Dong Shang Peiyuan Yin Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis−Induced Osteoporosis in Mice Metabolites chronic pancreatitis osteoporosis metabolomics lipidomics |
| title | Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis−Induced Osteoporosis in Mice |
| title_full | Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis−Induced Osteoporosis in Mice |
| title_fullStr | Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis−Induced Osteoporosis in Mice |
| title_full_unstemmed | Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis−Induced Osteoporosis in Mice |
| title_short | Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis−Induced Osteoporosis in Mice |
| title_sort | metabolomics approach revealed polyunsaturated fatty acid disorders as pathogenesis for chronic pancreatitis induced osteoporosis in mice |
| topic | chronic pancreatitis osteoporosis metabolomics lipidomics |
| url | https://www.mdpi.com/2218-1989/15/3/173 |
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