Retrospective Examınatıon of Children with Beta Lactam-Drug Allergy: A Single-Center Experience
Objective: The occurrence of drug reactions due to IgE or T-cell-mediated hypersensitivity reactions is referred to as drug allergy. Beta-lactam antibiotic (BLA) is the most common cause of drug allergy. In our study, we aimed to determine the true frequency of allergy in patients who presented to t...
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Istanbul University Press
2024-09-01
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| Series: | Çocuk Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/15505D5B548B4C38B4C4E617E85B1CB4 |
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| author | Şeyma Dilek Deniz Özçeker |
| author_facet | Şeyma Dilek Deniz Özçeker |
| author_sort | Şeyma Dilek |
| collection | DOAJ |
| description | Objective: The occurrence of drug reactions due to IgE or T-cell-mediated hypersensitivity reactions is referred to as drug allergy. Beta-lactam antibiotic (BLA) is the most common cause of drug allergy. In our study, we aimed to determine the true frequency of allergy in patients who presented to the children’s immunology and allergy polyclinic on suspicion of BLA allergy and performed drug provocation test (DPT) and to evaluate the clinical, demographic, and laboratory characteristics of these patients. Methods: Between 2017 and 2023, 141 patients (75 immediate reaction and 66 non immediate reaction) aged 0-18 years who applied to our hospital’s pediatric immunology and allergy outpatient clinic with suspicion of BLA allergy and underwent DPT were included. Retrospective records from the last 6 years were examined from hospital data; age (month), sex, history of concomitant chronic diseases, history of additional allergic diseases, history of drug allergies in the family, type of reaction, serum total IgE, percentage of eosinophils (%), history of BLA use (penicillin V, penicillin G, ampicillin, amoxicillin etc.), specific IgE values, and drug intradermal test (IDT) results were recorded. Results: In our study, 141 patients aged between 0 and 18 years were evaluated. 33 (23.4%) of them were IDT-positive. DPT was not performed because 24 patients did not have family permission and 9 patients experienced anaphylaxis. In our study, the BLA allergy rate determined by and/or skin tests was 26.9%, whereas the frequency of BLA allergy confirmed by DPT was 5.6%. Conclusions: Beta lactam antibiotics are widely used worldwide and are the most common cause of drug-induced allergic reactions. Diagnosing a drug allergy thought to be associated with BLA based on history alone leads to the unnecessary use of broad-spectrum antibiotics and, consequently, to the development of antibiotic resistance. The patients should be referred to the child allergy department to be able to be definitively diagnosed for patients with suspected BLA drug allergy. Thus, we hope that unnecessary broad-spectrum antibiotics will be prescribed and that the use of expensive drugs will be prevented. |
| format | Article |
| id | doaj-art-41bf4fbf14f04f04b3dbcd5e13fcce6c |
| institution | OA Journals |
| issn | 1308-8491 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | Çocuk Dergisi |
| spelling | doaj-art-41bf4fbf14f04f04b3dbcd5e13fcce6c2025-08-20T02:15:38ZengIstanbul University PressÇocuk Dergisi1308-84912024-09-0124318719210.26650/jchild.2024.1536100123456Retrospective Examınatıon of Children with Beta Lactam-Drug Allergy: A Single-Center ExperienceŞeyma Dilek0https://orcid.org/0009-0004-0840-2503Deniz Özçeker1https://orcid.org/0000-0002-0032-6727Sağlık Bilimleri Üniversitesi, Istanbul, TurkiyeSağlık Bilimleri Üniversitesi, Istanbul, TurkiyeObjective: The occurrence of drug reactions due to IgE or T-cell-mediated hypersensitivity reactions is referred to as drug allergy. Beta-lactam antibiotic (BLA) is the most common cause of drug allergy. In our study, we aimed to determine the true frequency of allergy in patients who presented to the children’s immunology and allergy polyclinic on suspicion of BLA allergy and performed drug provocation test (DPT) and to evaluate the clinical, demographic, and laboratory characteristics of these patients. Methods: Between 2017 and 2023, 141 patients (75 immediate reaction and 66 non immediate reaction) aged 0-18 years who applied to our hospital’s pediatric immunology and allergy outpatient clinic with suspicion of BLA allergy and underwent DPT were included. Retrospective records from the last 6 years were examined from hospital data; age (month), sex, history of concomitant chronic diseases, history of additional allergic diseases, history of drug allergies in the family, type of reaction, serum total IgE, percentage of eosinophils (%), history of BLA use (penicillin V, penicillin G, ampicillin, amoxicillin etc.), specific IgE values, and drug intradermal test (IDT) results were recorded. Results: In our study, 141 patients aged between 0 and 18 years were evaluated. 33 (23.4%) of them were IDT-positive. DPT was not performed because 24 patients did not have family permission and 9 patients experienced anaphylaxis. In our study, the BLA allergy rate determined by and/or skin tests was 26.9%, whereas the frequency of BLA allergy confirmed by DPT was 5.6%. Conclusions: Beta lactam antibiotics are widely used worldwide and are the most common cause of drug-induced allergic reactions. Diagnosing a drug allergy thought to be associated with BLA based on history alone leads to the unnecessary use of broad-spectrum antibiotics and, consequently, to the development of antibiotic resistance. The patients should be referred to the child allergy department to be able to be definitively diagnosed for patients with suspected BLA drug allergy. Thus, we hope that unnecessary broad-spectrum antibiotics will be prescribed and that the use of expensive drugs will be prevented.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/15505D5B548B4C38B4C4E617E85B1CB4childdrug allergybeta-lactampenicillincephalosporin |
| spellingShingle | Şeyma Dilek Deniz Özçeker Retrospective Examınatıon of Children with Beta Lactam-Drug Allergy: A Single-Center Experience Çocuk Dergisi child drug allergy beta-lactam penicillin cephalosporin |
| title | Retrospective Examınatıon of Children with Beta Lactam-Drug Allergy: A Single-Center Experience |
| title_full | Retrospective Examınatıon of Children with Beta Lactam-Drug Allergy: A Single-Center Experience |
| title_fullStr | Retrospective Examınatıon of Children with Beta Lactam-Drug Allergy: A Single-Center Experience |
| title_full_unstemmed | Retrospective Examınatıon of Children with Beta Lactam-Drug Allergy: A Single-Center Experience |
| title_short | Retrospective Examınatıon of Children with Beta Lactam-Drug Allergy: A Single-Center Experience |
| title_sort | retrospective examination of children with beta lactam drug allergy a single center experience |
| topic | child drug allergy beta-lactam penicillin cephalosporin |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/15505D5B548B4C38B4C4E617E85B1CB4 |
| work_keys_str_mv | AT seymadilek retrospectiveexamınatıonofchildrenwithbetalactamdrugallergyasinglecenterexperience AT denizozceker retrospectiveexamınatıonofchildrenwithbetalactamdrugallergyasinglecenterexperience |