Evaluation of Drug–Drug Interactions Between Clarithromycin and Direct Oral Anticoagulants Using Physiologically Based Pharmacokinetic Models

Evaluation of Drug–Drug Interactions Between Clarithromycin and Direct Oral Anticoagulants Using Physiologically Based Pharmacokinetic Models

<b>Objective:</b> This study assessed the pharmacokinetic (PK) interactions between clarithromycin (a P-glycoprotein [P-gp] inhibitor) and four direct oral anticoagulants (DOACs) (P-gp substrates) using physiologically based PK (PBPK) models to elucidate the influence of P-gp in the inte...

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Bibliographic Details
Main Authors: Zhuan Yang, Yuchen Qu, Yewen Sun, Jie Pan, Tong Zhou, Yunli Yu
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceutics
Subjects:
P-gp
DDI
PBPK
clarithromycin
DOACs
Online Access:https://www.mdpi.com/1999-4923/16/11/1449
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