The interplay between Salmonella and host: Mechanisms and strategies for bacterial survival
Salmonella, an intracellular pathogen, infects both humans and animals, causing diverse diseases such as gastroenteritis and enteric fever. The Salmonella type III secretion system (T3SS), encoded within its pathogenicity islands (SPIs), is critical for bacterial virulence by directly delivering mul...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Cell Insight |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772892725000112 |
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| author | Hongyu Zhao Xinyue Zhang Ningning Zhang Li Zhu Huan Lian |
| author_facet | Hongyu Zhao Xinyue Zhang Ningning Zhang Li Zhu Huan Lian |
| author_sort | Hongyu Zhao |
| collection | DOAJ |
| description | Salmonella, an intracellular pathogen, infects both humans and animals, causing diverse diseases such as gastroenteritis and enteric fever. The Salmonella type III secretion system (T3SS), encoded within its pathogenicity islands (SPIs), is critical for bacterial virulence by directly delivering multiple effectors into eukaryotic host cells. Salmonella utilizes these effectors to facilitate its survival and replication within the host through modulating cytoskeletal dynamics, inflammatory responses, the biogenesis of Salmonella-containing vacuole (SCV), and host cell survival. Moreover, these effectors also interfere with immune responses via inhibiting innate immunity or antigen presentation. In this review, we summarize the current progress in the survival strategies employed by Salmonella and the molecular mechanisms underlying its interactions with the host. Understanding the interplay between Salmonella and host can enhance our knowledge of the bacterium's pathogenic processes and provide new insights into how it manipulates host cellular physiological activities to ensure its survival. |
| format | Article |
| id | doaj-art-41b8b8be422647b99fd152d502f7daf9 |
| institution | OA Journals |
| issn | 2772-8927 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj-art-41b8b8be422647b99fd152d502f7daf92025-08-20T02:16:02ZengElsevierCell Insight2772-89272025-04-014210023710.1016/j.cellin.2025.100237The interplay between Salmonella and host: Mechanisms and strategies for bacterial survivalHongyu Zhao0Xinyue Zhang1Ningning Zhang2Li Zhu3Huan Lian4Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, Hubei, ChinaDepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, Hubei, ChinaYale Stem Cell Center, New Haven, CT, 06520, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT, 06510, USA; Yale Cooperative Center of Excellence in Hematology, New Haven, CT, 12208, USADepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, 06511, USADepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, Hubei, China; Corresponding author.Salmonella, an intracellular pathogen, infects both humans and animals, causing diverse diseases such as gastroenteritis and enteric fever. The Salmonella type III secretion system (T3SS), encoded within its pathogenicity islands (SPIs), is critical for bacterial virulence by directly delivering multiple effectors into eukaryotic host cells. Salmonella utilizes these effectors to facilitate its survival and replication within the host through modulating cytoskeletal dynamics, inflammatory responses, the biogenesis of Salmonella-containing vacuole (SCV), and host cell survival. Moreover, these effectors also interfere with immune responses via inhibiting innate immunity or antigen presentation. In this review, we summarize the current progress in the survival strategies employed by Salmonella and the molecular mechanisms underlying its interactions with the host. Understanding the interplay between Salmonella and host can enhance our knowledge of the bacterium's pathogenic processes and provide new insights into how it manipulates host cellular physiological activities to ensure its survival.http://www.sciencedirect.com/science/article/pii/S2772892725000112SalmonellaType III secretion systemVirulence effectorsCellular processesBacterial survivalPathogenesis |
| spellingShingle | Hongyu Zhao Xinyue Zhang Ningning Zhang Li Zhu Huan Lian The interplay between Salmonella and host: Mechanisms and strategies for bacterial survival Cell Insight Salmonella Type III secretion system Virulence effectors Cellular processes Bacterial survival Pathogenesis |
| title | The interplay between Salmonella and host: Mechanisms and strategies for bacterial survival |
| title_full | The interplay between Salmonella and host: Mechanisms and strategies for bacterial survival |
| title_fullStr | The interplay between Salmonella and host: Mechanisms and strategies for bacterial survival |
| title_full_unstemmed | The interplay between Salmonella and host: Mechanisms and strategies for bacterial survival |
| title_short | The interplay between Salmonella and host: Mechanisms and strategies for bacterial survival |
| title_sort | interplay between salmonella and host mechanisms and strategies for bacterial survival |
| topic | Salmonella Type III secretion system Virulence effectors Cellular processes Bacterial survival Pathogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S2772892725000112 |
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