Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease
A considerable number of studies have been conducted to study the microbial profiles in inflammatory conditions. A common phenomenon in inflammatory bowel disease (IBD) is the reduction of the diversity of microbiota, which demonstrates that microbial diversity negatively correlates with disease sev...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/6951091 |
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| author | Dawei Gong Xiaojie Gong Lili Wang Xinjuan Yu Quanjiang Dong |
| author_facet | Dawei Gong Xiaojie Gong Lili Wang Xinjuan Yu Quanjiang Dong |
| author_sort | Dawei Gong |
| collection | DOAJ |
| description | A considerable number of studies have been conducted to study the microbial profiles in inflammatory conditions. A common phenomenon in inflammatory bowel disease (IBD) is the reduction of the diversity of microbiota, which demonstrates that microbial diversity negatively correlates with disease severity in IBD. Increased microbial diversity is known to occur in disease remission. Species diversity plays an important role in maintaining the stability of the intestinal ecosystem as well as normal ecological function. A reduction in microbial diversity corresponds to a decrease in the stability of the ecosystem and can impair ecological function. Fecal microbiota transplantation (FMT), probiotics, and prebiotics, which aim to modulate the microbiota and restore its normal diversity, have been shown to be clinically efficacious. In this study, we hypothesized that a reduction in microbial diversity could play a role in the development of IBD. |
| format | Article |
| id | doaj-art-41b7bc774eac48729b002a01823f1f17 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-41b7bc774eac48729b002a01823f1f172025-08-20T02:08:24ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/69510916951091Involvement of Reduced Microbial Diversity in Inflammatory Bowel DiseaseDawei Gong0Xiaojie Gong1Lili Wang2Xinjuan Yu3Quanjiang Dong4Department of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, ChinaDepartment of Emergency Surgery, The Fifth People’s Hospital of Ji’nan, Ji’nan 250022, ChinaDepartment of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, ChinaDepartment of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, ChinaDepartment of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, ChinaA considerable number of studies have been conducted to study the microbial profiles in inflammatory conditions. A common phenomenon in inflammatory bowel disease (IBD) is the reduction of the diversity of microbiota, which demonstrates that microbial diversity negatively correlates with disease severity in IBD. Increased microbial diversity is known to occur in disease remission. Species diversity plays an important role in maintaining the stability of the intestinal ecosystem as well as normal ecological function. A reduction in microbial diversity corresponds to a decrease in the stability of the ecosystem and can impair ecological function. Fecal microbiota transplantation (FMT), probiotics, and prebiotics, which aim to modulate the microbiota and restore its normal diversity, have been shown to be clinically efficacious. In this study, we hypothesized that a reduction in microbial diversity could play a role in the development of IBD.http://dx.doi.org/10.1155/2016/6951091 |
| spellingShingle | Dawei Gong Xiaojie Gong Lili Wang Xinjuan Yu Quanjiang Dong Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease Gastroenterology Research and Practice |
| title | Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease |
| title_full | Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease |
| title_fullStr | Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease |
| title_full_unstemmed | Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease |
| title_short | Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease |
| title_sort | involvement of reduced microbial diversity in inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2016/6951091 |
| work_keys_str_mv | AT daweigong involvementofreducedmicrobialdiversityininflammatoryboweldisease AT xiaojiegong involvementofreducedmicrobialdiversityininflammatoryboweldisease AT liliwang involvementofreducedmicrobialdiversityininflammatoryboweldisease AT xinjuanyu involvementofreducedmicrobialdiversityininflammatoryboweldisease AT quanjiangdong involvementofreducedmicrobialdiversityininflammatoryboweldisease |