The potential of using itaconate as treatment for inflammation-related heart diseases
Intracellular metabolites can cause critical changes in biological functions. Itaconate is perhaps the most fascinating substance in macrophages. Lipopolysaccharide can activate aconitate decarboxylase 1 and induces the generation of itaconate from the tricarboxylic acid cycle by decarboxylation of...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Tzu Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=2;spage=113;epage=118;aulast=Ku |
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| _version_ | 1850216150250553344 |
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| author | Hui-Chen Ku Ta-Chung Shen Ching-Feng Cheng |
| author_facet | Hui-Chen Ku Ta-Chung Shen Ching-Feng Cheng |
| author_sort | Hui-Chen Ku |
| collection | DOAJ |
| description | Intracellular metabolites can cause critical changes in biological functions. Itaconate is perhaps the most fascinating substance in macrophages. Lipopolysaccharide can activate aconitate decarboxylase 1 and induces the generation of itaconate from the tricarboxylic acid cycle by decarboxylation of cis-aconitate. It has been reported that itaconate has beneficial effects on inflammation and oxidation. The mechanisms involved in these effects include the suppression of succinate dehydrogenase, the activation of nuclear factor E2-related factor 2 by alkylation of Kelch-like ECH-associated protein 1, suppression of aerobic glycolysis through regulation of glyceraldehyde-3-phosphate dehydrogenase and fructose-bisphosphate aldolase A, and suppression of IκBζ translation through activating transcription factor 3 activation. All of these findings elucidated the possible therapeutic implications of itaconate in inflammation-related diseases. In this review, we highlight that itaconate is a crucial molecule of the immunomodulatory response in macrophages and can regulate between immune response and cardiovascular metabolism. Furthermore, these discoveries suggest that itaconate is a very novel therapeutic molecule for the treatment of inflammation-related heart diseases. |
| format | Article |
| id | doaj-art-41b6f6e1cbc2454f9ab29ca06a7206d0 |
| institution | OA Journals |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-41b6f6e1cbc2454f9ab29ca06a7206d02025-08-20T02:08:24ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562022-01-0134211311810.4103/tcmj.tcmj_83_21The potential of using itaconate as treatment for inflammation-related heart diseasesHui-Chen KuTa-Chung ShenChing-Feng ChengIntracellular metabolites can cause critical changes in biological functions. Itaconate is perhaps the most fascinating substance in macrophages. Lipopolysaccharide can activate aconitate decarboxylase 1 and induces the generation of itaconate from the tricarboxylic acid cycle by decarboxylation of cis-aconitate. It has been reported that itaconate has beneficial effects on inflammation and oxidation. The mechanisms involved in these effects include the suppression of succinate dehydrogenase, the activation of nuclear factor E2-related factor 2 by alkylation of Kelch-like ECH-associated protein 1, suppression of aerobic glycolysis through regulation of glyceraldehyde-3-phosphate dehydrogenase and fructose-bisphosphate aldolase A, and suppression of IκBζ translation through activating transcription factor 3 activation. All of these findings elucidated the possible therapeutic implications of itaconate in inflammation-related diseases. In this review, we highlight that itaconate is a crucial molecule of the immunomodulatory response in macrophages and can regulate between immune response and cardiovascular metabolism. Furthermore, these discoveries suggest that itaconate is a very novel therapeutic molecule for the treatment of inflammation-related heart diseases.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=2;spage=113;epage=118;aulast=Kuactivating transcription factor 3inflammationitaconatenuclear factor erythroid 2-related factor 2succinate dehydrogenase |
| spellingShingle | Hui-Chen Ku Ta-Chung Shen Ching-Feng Cheng The potential of using itaconate as treatment for inflammation-related heart diseases Tzu Chi Medical Journal activating transcription factor 3 inflammation itaconate nuclear factor erythroid 2-related factor 2 succinate dehydrogenase |
| title | The potential of using itaconate as treatment for inflammation-related heart diseases |
| title_full | The potential of using itaconate as treatment for inflammation-related heart diseases |
| title_fullStr | The potential of using itaconate as treatment for inflammation-related heart diseases |
| title_full_unstemmed | The potential of using itaconate as treatment for inflammation-related heart diseases |
| title_short | The potential of using itaconate as treatment for inflammation-related heart diseases |
| title_sort | potential of using itaconate as treatment for inflammation related heart diseases |
| topic | activating transcription factor 3 inflammation itaconate nuclear factor erythroid 2-related factor 2 succinate dehydrogenase |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=2;spage=113;epage=118;aulast=Ku |
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