Microfabrication Technologies for Nanoinvasive and High‐Resolution Magnetic Neuromodulation
Abstract The increasing demand for precise neuromodulation necessitates advancements in techniques to achieve higher spatial resolution. Magnetic stimulation, offering low signal attenuation and minimal tissue damage, plays a significant role in neuromodulation. Conventional transcranial magnetic st...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202404254 |
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| author | Changhao Ge Tahereh Masalehdan Mahdieh Shojaei Baghini Vicente Duran Toro Lorenzo Signorelli Hannah Thomson Danijela Gregurec Hadi Heidari |
| author_facet | Changhao Ge Tahereh Masalehdan Mahdieh Shojaei Baghini Vicente Duran Toro Lorenzo Signorelli Hannah Thomson Danijela Gregurec Hadi Heidari |
| author_sort | Changhao Ge |
| collection | DOAJ |
| description | Abstract The increasing demand for precise neuromodulation necessitates advancements in techniques to achieve higher spatial resolution. Magnetic stimulation, offering low signal attenuation and minimal tissue damage, plays a significant role in neuromodulation. Conventional transcranial magnetic stimulation (TMS), though noninvasive, lacks the spatial resolution and neuron selectivity required for spatially precise neuromodulation. To address these limitations, the next generation of magnetic neurostimulation technologies aims to achieve submillimeter‐resolution and selective neuromodulation with high temporal resolution. Invasive and nanoinvasive magnetic neurostimulation are two next‐generation approaches: invasive methods use implantable microcoils, while nanoinvasive methods use magnetic nanoparticles (MNPs) to achieve high spatial and temporal resolution of magnetic neuromodulation. This review will introduce the working principles, technical details, coil designs, and potential future developments of these approaches from an engineering perspective. Furthermore, the review will discuss state‐of‐the‐art microfabrication in depth due to its irreplaceable role in realizing next‐generation magnetic neuromodulation. In addition to reviewing magnetic neuromodulation, this review will cover through‐silicon vias (TSV), surface micromachining, photolithography, direct writing, and other fabrication technologies, supported by case studies, providing a framework for the integration of magnetic neuromodulation and microelectronics technologies. |
| format | Article |
| id | doaj-art-41b405197cde4af3a8076626a5b803d2 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-41b405197cde4af3a8076626a5b803d22025-08-20T02:33:42ZengWileyAdvanced Science2198-38442024-12-011146n/an/a10.1002/advs.202404254Microfabrication Technologies for Nanoinvasive and High‐Resolution Magnetic NeuromodulationChanghao Ge0Tahereh Masalehdan1Mahdieh Shojaei Baghini2Vicente Duran Toro3Lorenzo Signorelli4Hannah Thomson5Danijela Gregurec6Hadi Heidari7Microelectronics Lab (meLAB) James Watt School of Engineering University of Glasgow Glasgow G12 8QQ UKMicroelectronics Lab (meLAB) James Watt School of Engineering University of Glasgow Glasgow G12 8QQ UKMicroelectronics Lab (meLAB) James Watt School of Engineering University of Glasgow Glasgow G12 8QQ UKBiointerfaces lab, Faculty of Sciences Friedrich‐Alexander‐Universität Erlangen‐Nürnberg Henkestraße 91 91052 Erlangen GermanyBiointerfaces lab, Faculty of Sciences Friedrich‐Alexander‐Universität Erlangen‐Nürnberg Henkestraße 91 91052 Erlangen GermanyMicroelectronics Lab (meLAB) James Watt School of Engineering University of Glasgow Glasgow G12 8QQ UKBiointerfaces lab, Faculty of Sciences Friedrich‐Alexander‐Universität Erlangen‐Nürnberg Henkestraße 91 91052 Erlangen GermanyMicroelectronics Lab (meLAB) James Watt School of Engineering University of Glasgow Glasgow G12 8QQ UKAbstract The increasing demand for precise neuromodulation necessitates advancements in techniques to achieve higher spatial resolution. Magnetic stimulation, offering low signal attenuation and minimal tissue damage, plays a significant role in neuromodulation. Conventional transcranial magnetic stimulation (TMS), though noninvasive, lacks the spatial resolution and neuron selectivity required for spatially precise neuromodulation. To address these limitations, the next generation of magnetic neurostimulation technologies aims to achieve submillimeter‐resolution and selective neuromodulation with high temporal resolution. Invasive and nanoinvasive magnetic neurostimulation are two next‐generation approaches: invasive methods use implantable microcoils, while nanoinvasive methods use magnetic nanoparticles (MNPs) to achieve high spatial and temporal resolution of magnetic neuromodulation. This review will introduce the working principles, technical details, coil designs, and potential future developments of these approaches from an engineering perspective. Furthermore, the review will discuss state‐of‐the‐art microfabrication in depth due to its irreplaceable role in realizing next‐generation magnetic neuromodulation. In addition to reviewing magnetic neuromodulation, this review will cover through‐silicon vias (TSV), surface micromachining, photolithography, direct writing, and other fabrication technologies, supported by case studies, providing a framework for the integration of magnetic neuromodulation and microelectronics technologies.https://doi.org/10.1002/advs.202404254magnetic stimulationmicrofabricationnanoinvasiveneuromodulationneurophysiology |
| spellingShingle | Changhao Ge Tahereh Masalehdan Mahdieh Shojaei Baghini Vicente Duran Toro Lorenzo Signorelli Hannah Thomson Danijela Gregurec Hadi Heidari Microfabrication Technologies for Nanoinvasive and High‐Resolution Magnetic Neuromodulation Advanced Science magnetic stimulation microfabrication nanoinvasive neuromodulation neurophysiology |
| title | Microfabrication Technologies for Nanoinvasive and High‐Resolution Magnetic Neuromodulation |
| title_full | Microfabrication Technologies for Nanoinvasive and High‐Resolution Magnetic Neuromodulation |
| title_fullStr | Microfabrication Technologies for Nanoinvasive and High‐Resolution Magnetic Neuromodulation |
| title_full_unstemmed | Microfabrication Technologies for Nanoinvasive and High‐Resolution Magnetic Neuromodulation |
| title_short | Microfabrication Technologies for Nanoinvasive and High‐Resolution Magnetic Neuromodulation |
| title_sort | microfabrication technologies for nanoinvasive and high resolution magnetic neuromodulation |
| topic | magnetic stimulation microfabrication nanoinvasive neuromodulation neurophysiology |
| url | https://doi.org/10.1002/advs.202404254 |
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