USP9X integrates TGF-β and hypoxia signalings to promote ovarian cancer chemoresistance via HIF-2α-maintained stemness

USP9X integrates TGF-β and hypoxia signalings to promote ovarian cancer chemoresistance via HIF-2α-maintained stemness

Abstract Widespread intraperitoneal metastases and chemoresistance render ovarian cancer the leading cause of gynecological malignancy-related deaths, wherein TGF-β signaling plays the pivotal role by promoting cancer stem cells (CSCs) activity. The activation mechanism and key protumorigeneic event...

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Main Authors: Zhenlei Zhang, Xiujie Yu, Liqi Wen, Jia’nan Wang, Zhufeng Li, Yu Zhang, Jiayu Cheng, Ronglin Kan, Wanting Zhang, Yan Shen, Shukai Yuan, Li Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07646-5
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