Lignan 7-hydroxymatairesinol in the context of post-genomic pharmacology
Objective: to determine the molecular mechanisms of action of 7-hydroxymatairesinol (7(OH)MR), the main lignan of spruce extracts, characterized by oncoprotective and anti-inflammatory properties.Material and methods. The analysis of 7(OH)MR was carried out by chemoinformatic approach using the comb...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2024-08-01
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| Series: | Фармакоэкономика |
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| Online Access: | https://www.pharmacoeconomics.ru/jour/article/view/1012 |
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| author | А. N. Rubashkina I. Yu. Torshin O. A. Gromova A. N. Galustyan |
| author_facet | А. N. Rubashkina I. Yu. Torshin O. A. Gromova A. N. Galustyan |
| author_sort | А. N. Rubashkina |
| collection | DOAJ |
| description | Objective: to determine the molecular mechanisms of action of 7-hydroxymatairesinol (7(OH)MR), the main lignan of spruce extracts, characterized by oncoprotective and anti-inflammatory properties.Material and methods. The analysis of 7(OH)MR was carried out by chemoinformatic approach using the combinatorial theory of solvability and the topological theory of recognition. The postgenomic approach makes it possible to assess the effect of drugs on genome transcription (transcriptome) and on the proteome as a whole.Results. 7(OH)MP has anti-inflammatory (inhibition of 5-lipoxygenase, matrix metalloproteinase 2, mitogen-activated kinase p38-alpha, leukotriene В4 receptor, prostacyclin receptor), and oncoprotective (antioxidant effect due to inhibition of heme oxygenase-2, inhibition of cyclin-dependent kinases 3 and 4, epidermal growth factor, mTOR protein) pharmacological effects.Conclusion. By reducing the expression of proliferative genes and genes involved in chronic inflammation, the 7(OH)MP molecule inhibits the proliferation of tumor cells. Pharmacoinformatic modeling showed that the anti-inflammatory effects of 7(OH)MR may contribute to increased lifespan in animal models. |
| format | Article |
| id | doaj-art-41b0bbea73ce4f67a6371668408e6b53 |
| institution | Kabale University |
| issn | 2070-4909 2070-4933 |
| language | Russian |
| publishDate | 2024-08-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Фармакоэкономика |
| spelling | doaj-art-41b0bbea73ce4f67a6371668408e6b532025-08-20T03:57:31ZrusIRBIS LLCФармакоэкономика2070-49092070-49332024-08-0117219119910.17749/2070-4909/farmakoekonomika.2024.240486Lignan 7-hydroxymatairesinol in the context of post-genomic pharmacologyА. N. Rubashkina0I. Yu. Torshin1O. A. Gromova2A. N. Galustyan3Ivanovo State Medical AcademyFederal Research Center “Computer Science and Control”, Russian Academy of SciencesFederal Research Center “Computer Science and Control”, Russian Academy of SciencesSaint Petersburg State Pediatric Medical UniversityObjective: to determine the molecular mechanisms of action of 7-hydroxymatairesinol (7(OH)MR), the main lignan of spruce extracts, characterized by oncoprotective and anti-inflammatory properties.Material and methods. The analysis of 7(OH)MR was carried out by chemoinformatic approach using the combinatorial theory of solvability and the topological theory of recognition. The postgenomic approach makes it possible to assess the effect of drugs on genome transcription (transcriptome) and on the proteome as a whole.Results. 7(OH)MP has anti-inflammatory (inhibition of 5-lipoxygenase, matrix metalloproteinase 2, mitogen-activated kinase p38-alpha, leukotriene В4 receptor, prostacyclin receptor), and oncoprotective (antioxidant effect due to inhibition of heme oxygenase-2, inhibition of cyclin-dependent kinases 3 and 4, epidermal growth factor, mTOR protein) pharmacological effects.Conclusion. By reducing the expression of proliferative genes and genes involved in chronic inflammation, the 7(OH)MP molecule inhibits the proliferation of tumor cells. Pharmacoinformatic modeling showed that the anti-inflammatory effects of 7(OH)MR may contribute to increased lifespan in animal models.https://www.pharmacoeconomics.ru/jour/article/view/1012mastopathylignanspathogenetic therapypharmacoinformaticshuman proteometranscriptomics |
| spellingShingle | А. N. Rubashkina I. Yu. Torshin O. A. Gromova A. N. Galustyan Lignan 7-hydroxymatairesinol in the context of post-genomic pharmacology Фармакоэкономика mastopathy lignans pathogenetic therapy pharmacoinformatics human proteome transcriptomics |
| title | Lignan 7-hydroxymatairesinol in the context of post-genomic pharmacology |
| title_full | Lignan 7-hydroxymatairesinol in the context of post-genomic pharmacology |
| title_fullStr | Lignan 7-hydroxymatairesinol in the context of post-genomic pharmacology |
| title_full_unstemmed | Lignan 7-hydroxymatairesinol in the context of post-genomic pharmacology |
| title_short | Lignan 7-hydroxymatairesinol in the context of post-genomic pharmacology |
| title_sort | lignan 7 hydroxymatairesinol in the context of post genomic pharmacology |
| topic | mastopathy lignans pathogenetic therapy pharmacoinformatics human proteome transcriptomics |
| url | https://www.pharmacoeconomics.ru/jour/article/view/1012 |
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