Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy response

Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy response

Abstract Colorectal cancer (CRC), including both microsatellite instability (MSI) and microsatellite stability (MSS) subtypes, frequently exhibits intrinsic resistance to immunotherapy. However, the spatial tumor microenvironment (TME) and its role in distinguishing immunotherapy responders from non...

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Main Authors: Hangyu Zhang, Libing Hong, Zhen Dong, Shan Xin, Bo Lin, Jinlin Cheng, Weihong Tian, Bin Li, Jing Wang, Xiaoyan Liu, Chuan Liu, Yuzhi Jin, Yanzhi Feng, Ge Su, Xuqi Sun, Qiqi Liu, Xiaomeng Dai, Yang Gao, Zhou Tong, Lulu Liu, Xudong Zhu, Yi Zheng, Peng Zhao, Tiannan Guo, Weijia Fang, Xuanwen Bao
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-025-00811-2
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