Cerebral perfusion as a modulator of structural-functional coupling and depressive symptoms: a blue-green light intervention study on subjective memory complaints in women
Aim Subjective memory complaint (SMC) is a preclinical Alzheimer’s manifestation, defined as self-reported memory impairment without objective signs in older individuals, particularly women. Blue-green light therapy has been shown to improve cognitive decline and affective deterioration. However, it...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Brain-Apparatus Communication |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/27706710.2025.2467951 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850139492477829120 |
|---|---|
| author | Shaolun Ma Yulin He Li Dong Haojie Huang Ao Xie Zihao Zheng Qiansen Feng Hongyi Li Jianfu Li Dezhong Yao Ziqi Wang |
| author_facet | Shaolun Ma Yulin He Li Dong Haojie Huang Ao Xie Zihao Zheng Qiansen Feng Hongyi Li Jianfu Li Dezhong Yao Ziqi Wang |
| author_sort | Shaolun Ma |
| collection | DOAJ |
| description | Aim Subjective memory complaint (SMC) is a preclinical Alzheimer’s manifestation, defined as self-reported memory impairment without objective signs in older individuals, particularly women. Blue-green light therapy has been shown to improve cognitive decline and affective deterioration. However, it remains unclear whether blue-green light affects the perfusional and structural-functional coupling of light-sensitive neural pathways in individuals with SMC.Methods In this study, 13 females with SMC underwent a blue-green light intervention. Changes in cerebral blood flow (CBF), structural-functional connectivity bandwidth, and depressive symptom scores were calculated, followed by a moderating analysis.Results We found that the alteration of CBF after light intervention showed a significant moderation effect on the relationship between the structural-functional coupling characteristics and depressive symptoms. In the right ventral tegmental area (VTA)-right lobule III of cerebellar hemisphere (CER3) edge (ΔCBF in VTA: ΔF = 13.625, p = 0.008; ΔCBF in CER3: ΔF = 23.584, p = 0.002), the intralaminar of thalamus (tIL)-VTA edge (ΔCBF in tIL: ΔF = 22.768, p = 0.002) and the left pulvinar lateral of thalamus (tPuL)-VTA edge (ΔCBF in tIL: ΔF = 11.835, p = 0.011), significant moderation effects of ΔCBF were found.Conclusion Our findings suggested that alterations of CBF might be critical modulating factors, interacting with the structural-functional coupling characteristics of light-sensitive pathways and ultimately regulating depressive symptoms. The current study may provide new insight regarding the physiological mechanisms underlying light-regulated depressive symptoms in older women with SMC. |
| format | Article |
| id | doaj-art-41a3ec6f095f4d2a8aeb18f8136abf45 |
| institution | OA Journals |
| issn | 2770-6710 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Brain-Apparatus Communication |
| spelling | doaj-art-41a3ec6f095f4d2a8aeb18f8136abf452025-08-20T02:30:15ZengTaylor & Francis GroupBrain-Apparatus Communication2770-67102025-12-014110.1080/27706710.2025.2467951Cerebral perfusion as a modulator of structural-functional coupling and depressive symptoms: a blue-green light intervention study on subjective memory complaints in womenShaolun Ma0Yulin He1Li Dong2Haojie Huang3Ao Xie4Zihao Zheng5Qiansen Feng6Hongyi Li7Jianfu Li8Dezhong Yao9Ziqi Wang10The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaAim Subjective memory complaint (SMC) is a preclinical Alzheimer’s manifestation, defined as self-reported memory impairment without objective signs in older individuals, particularly women. Blue-green light therapy has been shown to improve cognitive decline and affective deterioration. However, it remains unclear whether blue-green light affects the perfusional and structural-functional coupling of light-sensitive neural pathways in individuals with SMC.Methods In this study, 13 females with SMC underwent a blue-green light intervention. Changes in cerebral blood flow (CBF), structural-functional connectivity bandwidth, and depressive symptom scores were calculated, followed by a moderating analysis.Results We found that the alteration of CBF after light intervention showed a significant moderation effect on the relationship between the structural-functional coupling characteristics and depressive symptoms. In the right ventral tegmental area (VTA)-right lobule III of cerebellar hemisphere (CER3) edge (ΔCBF in VTA: ΔF = 13.625, p = 0.008; ΔCBF in CER3: ΔF = 23.584, p = 0.002), the intralaminar of thalamus (tIL)-VTA edge (ΔCBF in tIL: ΔF = 22.768, p = 0.002) and the left pulvinar lateral of thalamus (tPuL)-VTA edge (ΔCBF in tIL: ΔF = 11.835, p = 0.011), significant moderation effects of ΔCBF were found.Conclusion Our findings suggested that alterations of CBF might be critical modulating factors, interacting with the structural-functional coupling characteristics of light-sensitive pathways and ultimately regulating depressive symptoms. The current study may provide new insight regarding the physiological mechanisms underlying light-regulated depressive symptoms in older women with SMC.https://www.tandfonline.com/doi/10.1080/27706710.2025.2467951Alzheimer’s diseasecerebral blood flowdepressive symptomslight therapystructural-functional couplingsubjective memory complaints |
| spellingShingle | Shaolun Ma Yulin He Li Dong Haojie Huang Ao Xie Zihao Zheng Qiansen Feng Hongyi Li Jianfu Li Dezhong Yao Ziqi Wang Cerebral perfusion as a modulator of structural-functional coupling and depressive symptoms: a blue-green light intervention study on subjective memory complaints in women Brain-Apparatus Communication Alzheimer’s disease cerebral blood flow depressive symptoms light therapy structural-functional coupling subjective memory complaints |
| title | Cerebral perfusion as a modulator of structural-functional coupling and depressive symptoms: a blue-green light intervention study on subjective memory complaints in women |
| title_full | Cerebral perfusion as a modulator of structural-functional coupling and depressive symptoms: a blue-green light intervention study on subjective memory complaints in women |
| title_fullStr | Cerebral perfusion as a modulator of structural-functional coupling and depressive symptoms: a blue-green light intervention study on subjective memory complaints in women |
| title_full_unstemmed | Cerebral perfusion as a modulator of structural-functional coupling and depressive symptoms: a blue-green light intervention study on subjective memory complaints in women |
| title_short | Cerebral perfusion as a modulator of structural-functional coupling and depressive symptoms: a blue-green light intervention study on subjective memory complaints in women |
| title_sort | cerebral perfusion as a modulator of structural functional coupling and depressive symptoms a blue green light intervention study on subjective memory complaints in women |
| topic | Alzheimer’s disease cerebral blood flow depressive symptoms light therapy structural-functional coupling subjective memory complaints |
| url | https://www.tandfonline.com/doi/10.1080/27706710.2025.2467951 |
| work_keys_str_mv | AT shaolunma cerebralperfusionasamodulatorofstructuralfunctionalcouplinganddepressivesymptomsabluegreenlightinterventionstudyonsubjectivememorycomplaintsinwomen AT yulinhe cerebralperfusionasamodulatorofstructuralfunctionalcouplinganddepressivesymptomsabluegreenlightinterventionstudyonsubjectivememorycomplaintsinwomen AT lidong cerebralperfusionasamodulatorofstructuralfunctionalcouplinganddepressivesymptomsabluegreenlightinterventionstudyonsubjectivememorycomplaintsinwomen AT haojiehuang cerebralperfusionasamodulatorofstructuralfunctionalcouplinganddepressivesymptomsabluegreenlightinterventionstudyonsubjectivememorycomplaintsinwomen AT aoxie cerebralperfusionasamodulatorofstructuralfunctionalcouplinganddepressivesymptomsabluegreenlightinterventionstudyonsubjectivememorycomplaintsinwomen AT zihaozheng cerebralperfusionasamodulatorofstructuralfunctionalcouplinganddepressivesymptomsabluegreenlightinterventionstudyonsubjectivememorycomplaintsinwomen AT qiansenfeng cerebralperfusionasamodulatorofstructuralfunctionalcouplinganddepressivesymptomsabluegreenlightinterventionstudyonsubjectivememorycomplaintsinwomen AT hongyili cerebralperfusionasamodulatorofstructuralfunctionalcouplinganddepressivesymptomsabluegreenlightinterventionstudyonsubjectivememorycomplaintsinwomen AT jianfuli cerebralperfusionasamodulatorofstructuralfunctionalcouplinganddepressivesymptomsabluegreenlightinterventionstudyonsubjectivememorycomplaintsinwomen AT dezhongyao cerebralperfusionasamodulatorofstructuralfunctionalcouplinganddepressivesymptomsabluegreenlightinterventionstudyonsubjectivememorycomplaintsinwomen AT ziqiwang cerebralperfusionasamodulatorofstructuralfunctionalcouplinganddepressivesymptomsabluegreenlightinterventionstudyonsubjectivememorycomplaintsinwomen |