The effects of Klotho delivering mesenchymal stem cell-derived small extracellular vesicles on acute kidney injury

The effects of Klotho delivering mesenchymal stem cell-derived small extracellular vesicles on acute kidney injury

Abstract Acute kidney injury (AKI) is a life-threating syndrome characterized by sudden loss of kidney function, and its management is challenging and often suboptimal. Mesenchymal stem cells (MSCs) have shown promise in AKI therapy in pre-clinical and clinical trials; however, their clinical applic...

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Main Authors: Xiao-Hui Deng, Zi-Cong Wu, Qi Sun, Long-Xin Huang, Ying-Chun Xie, Dong-Xiao Lou, Chan-Gu Li, Xiao-Qing Liu, Zhi-Rou Zhou, Tian Tian, Chang-Lin Lian, Qing-Ling Fu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Subjects:
Mesenchymal stem cells
Small extracellular vesicles
Klotho
Acute kidney injury
Reno-protection
Online Access:https://doi.org/10.1186/s12951-025-03499-4
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