Performance based on NEMA NU-4 2008 Standard of CDTN/CNEN’s Small Animal PET Scanner
This study aimed to evaluate the general performance of the preclinical PET scanner (LabPET Solo 4, GE) at CDTN/CNEN using the NEMA NU 4-2008 protocol. The performance parameters include: (i) spatial resolution; (ii) scatter fraction and counts rate performance; (iii) sensitivity and (iv) image qual...
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Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)
2022-09-01
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| Series: | Brazilian Journal of Radiation Sciences |
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| Online Access: | https://bjrs.org.br/revista/index.php/REVISTA/article/view/2006 |
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| author | Rodrigo Modesto Gadelha Gontijo Andréa Vidal Ferreira Juliana Batista da Silva Marcelo Mamede |
| author_facet | Rodrigo Modesto Gadelha Gontijo Andréa Vidal Ferreira Juliana Batista da Silva Marcelo Mamede |
| author_sort | Rodrigo Modesto Gadelha Gontijo |
| collection | DOAJ |
| description | This study aimed to evaluate the general performance of the preclinical PET scanner (LabPET Solo 4, GE) at CDTN/CNEN using the NEMA NU 4-2008 protocol. The performance parameters include: (i) spatial resolution; (ii) scatter fraction and counts rate performance; (iii) sensitivity and (iv) image quality. For the evaluation specific simulators and a sealed radioactive source of Sodium-22 were used. The results revealed that the NEMA-based radial spatial resolution ranged from 1.79 mm at the center of the FOV to 2.49 mm at a radial offset of 25mm. Tangential resolution ranged from 1.95mm at the center of the FOV to 3.50mm at a radial offset of 25mm. Axial resolution ranged from 1.78mm at the center of the FOV to 5.42mm at a radial offset of 25mm. Iterative image reconstruction improved the radial spatial resolution to 0.93mm at the center of the FOV. For the mouse-sized phantom, the peak noise equivalent count rate (NECR) was 37.8kcps at 85MBq whereas the peak true count rate was 169.9kcps at 125MBq with a count loss of 7.8% for the maximum rate reached at 103.3MBq. The peak of sensitivity (S) and absolute sensitivity (SA) at the center of axial field-of-view (FOV) is 5.7cps.Bq-1 and 0.63%, respectively. The overall imaging capabilities of the scanner were assessed using the NEMA image-quality phantom. The image roughness was 9.5%. Spillover rates (SORs) in air and in water were 0.26 and 0.17 respectively. The recovery coefficients (RCs) were 0.12 for the 1-mm-diameter rod and 0.91 for the 5-mm-diameter rod. The results demonstrate that CDTN/CNENsmall animal PET scanner has adequate reliability and acquired images are compatible with international quality standards for the molecular imaging research. |
| format | Article |
| id | doaj-art-419ec22d3de7436aa2a6be3c778ee9a4 |
| institution | Kabale University |
| issn | 2319-0612 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) |
| record_format | Article |
| series | Brazilian Journal of Radiation Sciences |
| spelling | doaj-art-419ec22d3de7436aa2a6be3c778ee9a42025-08-20T03:50:49ZengBrazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)Brazilian Journal of Radiation Sciences2319-06122022-09-0110310.15392/bjrs.v10i3.20061624Performance based on NEMA NU-4 2008 Standard of CDTN/CNEN’s Small Animal PET ScannerRodrigo Modesto Gadelha Gontijo0Andréa Vidal Ferreira1Juliana Batista da Silva2Marcelo Mamede3Federal University of Minas GeraisCentro de Desenvolvimento da Tecnologia Nuclear (CDTN)Centro de Desenvolvimento da Tecnologia Nuclear (CDTN)UFMGThis study aimed to evaluate the general performance of the preclinical PET scanner (LabPET Solo 4, GE) at CDTN/CNEN using the NEMA NU 4-2008 protocol. The performance parameters include: (i) spatial resolution; (ii) scatter fraction and counts rate performance; (iii) sensitivity and (iv) image quality. For the evaluation specific simulators and a sealed radioactive source of Sodium-22 were used. The results revealed that the NEMA-based radial spatial resolution ranged from 1.79 mm at the center of the FOV to 2.49 mm at a radial offset of 25mm. Tangential resolution ranged from 1.95mm at the center of the FOV to 3.50mm at a radial offset of 25mm. Axial resolution ranged from 1.78mm at the center of the FOV to 5.42mm at a radial offset of 25mm. Iterative image reconstruction improved the radial spatial resolution to 0.93mm at the center of the FOV. For the mouse-sized phantom, the peak noise equivalent count rate (NECR) was 37.8kcps at 85MBq whereas the peak true count rate was 169.9kcps at 125MBq with a count loss of 7.8% for the maximum rate reached at 103.3MBq. The peak of sensitivity (S) and absolute sensitivity (SA) at the center of axial field-of-view (FOV) is 5.7cps.Bq-1 and 0.63%, respectively. The overall imaging capabilities of the scanner were assessed using the NEMA image-quality phantom. The image roughness was 9.5%. Spillover rates (SORs) in air and in water were 0.26 and 0.17 respectively. The recovery coefficients (RCs) were 0.12 for the 1-mm-diameter rod and 0.91 for the 5-mm-diameter rod. The results demonstrate that CDTN/CNENsmall animal PET scanner has adequate reliability and acquired images are compatible with international quality standards for the molecular imaging research.https://bjrs.org.br/revista/index.php/REVISTA/article/view/2006quality controlnema nu 4-2008preclinical pet |
| spellingShingle | Rodrigo Modesto Gadelha Gontijo Andréa Vidal Ferreira Juliana Batista da Silva Marcelo Mamede Performance based on NEMA NU-4 2008 Standard of CDTN/CNEN’s Small Animal PET Scanner Brazilian Journal of Radiation Sciences quality control nema nu 4-2008 preclinical pet |
| title | Performance based on NEMA NU-4 2008 Standard of CDTN/CNEN’s Small Animal PET Scanner |
| title_full | Performance based on NEMA NU-4 2008 Standard of CDTN/CNEN’s Small Animal PET Scanner |
| title_fullStr | Performance based on NEMA NU-4 2008 Standard of CDTN/CNEN’s Small Animal PET Scanner |
| title_full_unstemmed | Performance based on NEMA NU-4 2008 Standard of CDTN/CNEN’s Small Animal PET Scanner |
| title_short | Performance based on NEMA NU-4 2008 Standard of CDTN/CNEN’s Small Animal PET Scanner |
| title_sort | performance based on nema nu 4 2008 standard of cdtn cnen s small animal pet scanner |
| topic | quality control nema nu 4-2008 preclinical pet |
| url | https://bjrs.org.br/revista/index.php/REVISTA/article/view/2006 |
| work_keys_str_mv | AT rodrigomodestogadelhagontijo performancebasedonnemanu42008standardofcdtncnenssmallanimalpetscanner AT andreavidalferreira performancebasedonnemanu42008standardofcdtncnenssmallanimalpetscanner AT julianabatistadasilva performancebasedonnemanu42008standardofcdtncnenssmallanimalpetscanner AT marcelomamede performancebasedonnemanu42008standardofcdtncnenssmallanimalpetscanner |