Comparison of Hemodynamic Status with Three Different Doses of Lidocaine as an Adjunct to Propofol-Remifentanil During Endotracheal Intubation in Elderly Female Patients: A Prospective Randomized Study
Fei Xiao,1,2 Lu-Qi Xu,2 Hai-Ya Yan,1 Si Zhou,2 Jia-Ming Fan,2 Lin Liu2 1Department of Anesthesiology, The Affiliated Women and Children’s Hospital of Ningbo University, Ningbo, People’s Republic of China; 2Department of Anesthesiology, Jiaxing Women and Children’s Hospital, Wenzhou Medical Universit...
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Dove Medical Press
2025-07-01
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| author | Xiao F Xu LQ Yan HY Zhou S Fan JM Liu L |
| author_facet | Xiao F Xu LQ Yan HY Zhou S Fan JM Liu L |
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| description | Fei Xiao,1,2 Lu-Qi Xu,2 Hai-Ya Yan,1 Si Zhou,2 Jia-Ming Fan,2 Lin Liu2 1Department of Anesthesiology, The Affiliated Women and Children’s Hospital of Ningbo University, Ningbo, People’s Republic of China; 2Department of Anesthesiology, Jiaxing Women and Children’s Hospital, Wenzhou Medical University, Jiaxing, People’s Republic of ChinaCorrespondence: Lin Liu, Department of Anesthesiology, Jiaxing Women and Children’s Hospital, Wenzhou Medical University, 2468&num;, East Zhonghuang Road, Jiaxing, People’s Republic of China, Tel +86 573 83963131, Email 13967358623@163.com Jia-Ming Fan, Department of Anesthesiology, Jiaxing University Affiliated Women and Children Hospital, 2468&num;, East Zhonghuang Road, Jiaxing, People’s Republic of China, Tel +86 573 83963131, Email 254602480@qq.comBackground: Lidocaine was reported to stabilize the hemodynamic status and reduce the incidence of postinduction hypotension in elderly patients. However, the optimal dose of lidocaine as an adjuvant to propofol-remifentanil during endotracheal intubation in elderly female patients remains uncertain. In this study, we aimed to determine the optimal dose of lidocaine as an adjuvant for propofol-remifentanil in elderly female patients.Methods: Two hundred and forty patients were randomly assigned to one of three groups in a ratio of 1:1:1, each receiving a different dosage of lidocaine: 0.5 mg/kg, 1.0 mg/kg, or 1.5 mg/kg, with propofol-remifentanil for endotracheal intubation. Patients’ hemodynamic parameters were continuously monitored 10 minutes after the induction of anesthesia. Hypotension, defined as a mean arterial pressure < 70% of the baseline value and/or < 65 mm Hg, and treated with norepinephrine 4 μg, repeated as necessary. Norepinephrine consumption (primary outcome), mean arterial pressure, heart rate, and propofol consumption were recorded.Results: The incidence of hypotension was 51.4% (37/72), 13.0% (9/69), and 13.8% (9/65) in Groups 0.5, 1.0, and 1.5, respectively. The median (25th and 75th quartiles) consumption of norepinephrine was 4 (0– 4) μg, 0 (0– 0) μg, and 0 (0– 0) μg across the groups, respectively; there was a significant difference among the groups (p = 0.0006). The incidence of hypertension was 15.7% (11/72), 5.8% (4/69), and 6.2% (4/65) across the groups, respectively.Conclusion: In summary, under the conditions of this study, we propose that 1.0 mg/kg lidocaine may be considered as an optimal dose when used as an adjuvant to propofol-remifentanil for endotracheal intubation.Clinical Trial Registration: Chinese Clinical Trial Registry number: ChiCTR2400092990 https://www.chictr.org.cn/bin/project/edit?pid=231367.Keywords: lidocaine, propofol, hypotension, elderly, anesthesia |
| format | Article |
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| language | English |
| publishDate | 2025-07-01 |
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| series | Drug Design, Development and Therapy |
| spelling | doaj-art-419b37ed23f94511b564d1f857ecb9182025-08-20T02:46:05ZengDove Medical PressDrug Design, Development and Therapy1177-88812025-07-01Volume 19Issue 164616468105272Comparison of Hemodynamic Status with Three Different Doses of Lidocaine as an Adjunct to Propofol-Remifentanil During Endotracheal Intubation in Elderly Female Patients: A Prospective Randomized StudyXiao F0Xu LQYan HYZhou SFan JM1Liu L2Department of AnesthesiologyDepartment of AnesthesiologyDepartment of AnesthesiologyFei Xiao,1,2 Lu-Qi Xu,2 Hai-Ya Yan,1 Si Zhou,2 Jia-Ming Fan,2 Lin Liu2 1Department of Anesthesiology, The Affiliated Women and Children’s Hospital of Ningbo University, Ningbo, People’s Republic of China; 2Department of Anesthesiology, Jiaxing Women and Children’s Hospital, Wenzhou Medical University, Jiaxing, People’s Republic of ChinaCorrespondence: Lin Liu, Department of Anesthesiology, Jiaxing Women and Children’s Hospital, Wenzhou Medical University, 2468&num;, East Zhonghuang Road, Jiaxing, People’s Republic of China, Tel +86 573 83963131, Email 13967358623@163.com Jia-Ming Fan, Department of Anesthesiology, Jiaxing University Affiliated Women and Children Hospital, 2468&num;, East Zhonghuang Road, Jiaxing, People’s Republic of China, Tel +86 573 83963131, Email 254602480@qq.comBackground: Lidocaine was reported to stabilize the hemodynamic status and reduce the incidence of postinduction hypotension in elderly patients. However, the optimal dose of lidocaine as an adjuvant to propofol-remifentanil during endotracheal intubation in elderly female patients remains uncertain. In this study, we aimed to determine the optimal dose of lidocaine as an adjuvant for propofol-remifentanil in elderly female patients.Methods: Two hundred and forty patients were randomly assigned to one of three groups in a ratio of 1:1:1, each receiving a different dosage of lidocaine: 0.5 mg/kg, 1.0 mg/kg, or 1.5 mg/kg, with propofol-remifentanil for endotracheal intubation. Patients’ hemodynamic parameters were continuously monitored 10 minutes after the induction of anesthesia. Hypotension, defined as a mean arterial pressure < 70% of the baseline value and/or < 65 mm Hg, and treated with norepinephrine 4 μg, repeated as necessary. Norepinephrine consumption (primary outcome), mean arterial pressure, heart rate, and propofol consumption were recorded.Results: The incidence of hypotension was 51.4% (37/72), 13.0% (9/69), and 13.8% (9/65) in Groups 0.5, 1.0, and 1.5, respectively. The median (25th and 75th quartiles) consumption of norepinephrine was 4 (0– 4) μg, 0 (0– 0) μg, and 0 (0– 0) μg across the groups, respectively; there was a significant difference among the groups (p = 0.0006). The incidence of hypertension was 15.7% (11/72), 5.8% (4/69), and 6.2% (4/65) across the groups, respectively.Conclusion: In summary, under the conditions of this study, we propose that 1.0 mg/kg lidocaine may be considered as an optimal dose when used as an adjuvant to propofol-remifentanil for endotracheal intubation.Clinical Trial Registration: Chinese Clinical Trial Registry number: ChiCTR2400092990 https://www.chictr.org.cn/bin/project/edit?pid=231367.Keywords: lidocaine, propofol, hypotension, elderly, anesthesiahttps://www.dovepress.com/comparison-of-hemodynamic-status-with-three-different-doses-of-lidocai-peer-reviewed-fulltext-article-DDDTLidocainePropofolHypotensionElderlyAnesthesia |
| spellingShingle | Xiao F Xu LQ Yan HY Zhou S Fan JM Liu L Comparison of Hemodynamic Status with Three Different Doses of Lidocaine as an Adjunct to Propofol-Remifentanil During Endotracheal Intubation in Elderly Female Patients: A Prospective Randomized Study Drug Design, Development and Therapy Lidocaine Propofol Hypotension Elderly Anesthesia |
| title | Comparison of Hemodynamic Status with Three Different Doses of Lidocaine as an Adjunct to Propofol-Remifentanil During Endotracheal Intubation in Elderly Female Patients: A Prospective Randomized Study |
| title_full | Comparison of Hemodynamic Status with Three Different Doses of Lidocaine as an Adjunct to Propofol-Remifentanil During Endotracheal Intubation in Elderly Female Patients: A Prospective Randomized Study |
| title_fullStr | Comparison of Hemodynamic Status with Three Different Doses of Lidocaine as an Adjunct to Propofol-Remifentanil During Endotracheal Intubation in Elderly Female Patients: A Prospective Randomized Study |
| title_full_unstemmed | Comparison of Hemodynamic Status with Three Different Doses of Lidocaine as an Adjunct to Propofol-Remifentanil During Endotracheal Intubation in Elderly Female Patients: A Prospective Randomized Study |
| title_short | Comparison of Hemodynamic Status with Three Different Doses of Lidocaine as an Adjunct to Propofol-Remifentanil During Endotracheal Intubation in Elderly Female Patients: A Prospective Randomized Study |
| title_sort | comparison of hemodynamic status with three different doses of lidocaine as an adjunct to propofol remifentanil during endotracheal intubation in elderly female patients a prospective randomized study |
| topic | Lidocaine Propofol Hypotension Elderly Anesthesia |
| url | https://www.dovepress.com/comparison-of-hemodynamic-status-with-three-different-doses-of-lidocai-peer-reviewed-fulltext-article-DDDT |
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