Clinical significance of microRNA-328-3p and bone metabolism biomarkers in gout patients with different musculoskeletal ultrasonography imaging
Abstract Aims MicroRNA (miRNA) participates in the pathophysiological processes of multiple metabolic diseases, including gout. In gout patients, there is concomitant derangement of bone metabolism. The study aimed to explore the correlation of different ultrasonic manifestations and miR-328-3p leve...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
|
| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-025-05691-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850217044369211392 |
|---|---|
| author | Qingqing Song Lifang Xue Jie Ren Xiaoyu Liu Guilei Li Congcong Liu Xin Meng |
| author_facet | Qingqing Song Lifang Xue Jie Ren Xiaoyu Liu Guilei Li Congcong Liu Xin Meng |
| author_sort | Qingqing Song |
| collection | DOAJ |
| description | Abstract Aims MicroRNA (miRNA) participates in the pathophysiological processes of multiple metabolic diseases, including gout. In gout patients, there is concomitant derangement of bone metabolism. The study aimed to explore the correlation of different ultrasonic manifestations and miR-328-3p levels with bone metabolic markers in gout patients. Methods A total of 320 gout patients were grouped according to musculoskeletal ultrasound (MSUS) imaging. Serum osteocalcin (BGP), C-terminal telopeptide of type I collagen (CTX-I) and osteopotin (OPN) levels were detected to evaluate bone metabolism. Serum miR-328-3p levels were detected via qRT-PCR. Pearson’s correlation analysis was performed to explore the relationships between the variables. Results Patients with tophi accompanied by bone erosion demonstrated significantly elevated levels of BGP and OPN compared to those with tophi or aggregate of MSU crystals in the absence of bone erosions. Cases with long course of disease exhibited more severe bone destruction. Cases without specific clinical manifestations presented the highest levels of serum miR-328-3p, whereas those with bone erosions demonstrated the lowest values. Significantly negative correlations were also detected for serum miR-328-3p levels with BGP and OPN values in all gout patients. Conclusion Serum miR-328-3p levels were associated with diverse MSUS manifestations in gout patients. MSUS imaging and miR-328-3p levels are capable of reflecting the joint impairment in gout patients. |
| format | Article |
| id | doaj-art-419630c353bf4436bf7da5bbff9518a9 |
| institution | OA Journals |
| issn | 1749-799X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-419630c353bf4436bf7da5bbff9518a92025-08-20T02:08:09ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2025-04-012011710.1186/s13018-025-05691-6Clinical significance of microRNA-328-3p and bone metabolism biomarkers in gout patients with different musculoskeletal ultrasonography imagingQingqing Song0Lifang Xue1Jie Ren2Xiaoyu Liu3Guilei Li4Congcong Liu5Xin Meng6Department of Ultrasonography, Shengli Oilfield Central HospitalDepartment of Ultrasonography, Shengli Oilfield Central HospitalDepartment of Ultrasonography, Shengli Oilfield Central HospitalDepartment of Ultrasonography, Shengli Oilfield Central HospitalClinical Laboratory, Shengli Oilfield Central HospitalClinical Laboratory, Shengli Oilfield Central HospitalDepartment of Ultrasonography, Shengli Oilfield Central HospitalAbstract Aims MicroRNA (miRNA) participates in the pathophysiological processes of multiple metabolic diseases, including gout. In gout patients, there is concomitant derangement of bone metabolism. The study aimed to explore the correlation of different ultrasonic manifestations and miR-328-3p levels with bone metabolic markers in gout patients. Methods A total of 320 gout patients were grouped according to musculoskeletal ultrasound (MSUS) imaging. Serum osteocalcin (BGP), C-terminal telopeptide of type I collagen (CTX-I) and osteopotin (OPN) levels were detected to evaluate bone metabolism. Serum miR-328-3p levels were detected via qRT-PCR. Pearson’s correlation analysis was performed to explore the relationships between the variables. Results Patients with tophi accompanied by bone erosion demonstrated significantly elevated levels of BGP and OPN compared to those with tophi or aggregate of MSU crystals in the absence of bone erosions. Cases with long course of disease exhibited more severe bone destruction. Cases without specific clinical manifestations presented the highest levels of serum miR-328-3p, whereas those with bone erosions demonstrated the lowest values. Significantly negative correlations were also detected for serum miR-328-3p levels with BGP and OPN values in all gout patients. Conclusion Serum miR-328-3p levels were associated with diverse MSUS manifestations in gout patients. MSUS imaging and miR-328-3p levels are capable of reflecting the joint impairment in gout patients.https://doi.org/10.1186/s13018-025-05691-6Bone metabolismmiR-328-3pGoutMusculoskeletal ultrasound |
| spellingShingle | Qingqing Song Lifang Xue Jie Ren Xiaoyu Liu Guilei Li Congcong Liu Xin Meng Clinical significance of microRNA-328-3p and bone metabolism biomarkers in gout patients with different musculoskeletal ultrasonography imaging Journal of Orthopaedic Surgery and Research Bone metabolism miR-328-3p Gout Musculoskeletal ultrasound |
| title | Clinical significance of microRNA-328-3p and bone metabolism biomarkers in gout patients with different musculoskeletal ultrasonography imaging |
| title_full | Clinical significance of microRNA-328-3p and bone metabolism biomarkers in gout patients with different musculoskeletal ultrasonography imaging |
| title_fullStr | Clinical significance of microRNA-328-3p and bone metabolism biomarkers in gout patients with different musculoskeletal ultrasonography imaging |
| title_full_unstemmed | Clinical significance of microRNA-328-3p and bone metabolism biomarkers in gout patients with different musculoskeletal ultrasonography imaging |
| title_short | Clinical significance of microRNA-328-3p and bone metabolism biomarkers in gout patients with different musculoskeletal ultrasonography imaging |
| title_sort | clinical significance of microrna 328 3p and bone metabolism biomarkers in gout patients with different musculoskeletal ultrasonography imaging |
| topic | Bone metabolism miR-328-3p Gout Musculoskeletal ultrasound |
| url | https://doi.org/10.1186/s13018-025-05691-6 |
| work_keys_str_mv | AT qingqingsong clinicalsignificanceofmicrorna3283pandbonemetabolismbiomarkersingoutpatientswithdifferentmusculoskeletalultrasonographyimaging AT lifangxue clinicalsignificanceofmicrorna3283pandbonemetabolismbiomarkersingoutpatientswithdifferentmusculoskeletalultrasonographyimaging AT jieren clinicalsignificanceofmicrorna3283pandbonemetabolismbiomarkersingoutpatientswithdifferentmusculoskeletalultrasonographyimaging AT xiaoyuliu clinicalsignificanceofmicrorna3283pandbonemetabolismbiomarkersingoutpatientswithdifferentmusculoskeletalultrasonographyimaging AT guileili clinicalsignificanceofmicrorna3283pandbonemetabolismbiomarkersingoutpatientswithdifferentmusculoskeletalultrasonographyimaging AT congcongliu clinicalsignificanceofmicrorna3283pandbonemetabolismbiomarkersingoutpatientswithdifferentmusculoskeletalultrasonographyimaging AT xinmeng clinicalsignificanceofmicrorna3283pandbonemetabolismbiomarkersingoutpatientswithdifferentmusculoskeletalultrasonographyimaging |