A comparative study of mitoxantrone hydrochloride injection and technetium-99 m for tracing axillary sentinel nodes in patients with breast cancer
Abstract Purpose An earlier multicenter phase III study demonstrated the safety and efficacy of mitoxantrone hydrochloride injection for tracing (MHI) for detecting sentinel lymph nodes (SLNs) in breast cancer patients. This ancillary study was conducted to further analyze and discover differences b...
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2025-02-01
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| Online Access: | https://doi.org/10.1186/s12885-025-13618-x |
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| author | Dechuang Jiao Xiuchun Chen Xianfu Sun Zhenduo Lu Hao Dai Chengzheng Wang Chongjian Zhang Lianfang Li Jianghua Qiao Zhenzhen Liu |
| author_facet | Dechuang Jiao Xiuchun Chen Xianfu Sun Zhenduo Lu Hao Dai Chengzheng Wang Chongjian Zhang Lianfang Li Jianghua Qiao Zhenzhen Liu |
| author_sort | Dechuang Jiao |
| collection | DOAJ |
| description | Abstract Purpose An earlier multicenter phase III study demonstrated the safety and efficacy of mitoxantrone hydrochloride injection for tracing (MHI) for detecting sentinel lymph nodes (SLNs) in breast cancer patients. This ancillary study was conducted to further analyze and discover differences between the two tracers that had not been reported previously. Methods This analysis used single-center data from a phase III trial. Patients with breast cancer were injected with both MHI and 99mTc as SLN tracers before surgery. To account for cluster effects of multiple SLNs from the same patient and further analyze the differences between the two methods and factors that could impact detection, Obuchowski’s modified McNemar test, the GLIMMIX model, and univariate and multivariate analyses were used as appropriate. Results In total, 463 SLNs from 109 patients were resected, 47 of which were pathologically positive. The SLN detection rate did not significantly differ between MHI and 99mTc. MHI blue staining was an independent predictor of pathological positivity (OR 3.58, 95% CI: 1.21–10.60, p = 0.02), while the 99mTc signal was not significant in the same model (p = 0.39). Conclusion MHI was comparable to 99mTc in safety and SLN detection rates but differed in sensitivity on positive SLNs. |
| format | Article |
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| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj-art-41945b89dbd24ee0b6b383f03607535d2025-02-09T12:41:32ZengBMCBMC Cancer1471-24072025-02-012511710.1186/s12885-025-13618-xA comparative study of mitoxantrone hydrochloride injection and technetium-99 m for tracing axillary sentinel nodes in patients with breast cancerDechuang Jiao0Xiuchun Chen1Xianfu Sun2Zhenduo Lu3Hao Dai4Chengzheng Wang5Chongjian Zhang6Lianfang Li7Jianghua Qiao8Zhenzhen Liu9Department of Breast Disease, Henan Breast Cancer Centre, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Breast Disease, Henan Breast Cancer Centre, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Breast Disease, Henan Breast Cancer Centre, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Breast Disease, Henan Breast Cancer Centre, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Breast Disease, Henan Breast Cancer Centre, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Breast Disease, Henan Breast Cancer Centre, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Breast Disease, Henan Breast Cancer Centre, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Breast Disease, Henan Breast Cancer Centre, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Breast Disease, Henan Breast Cancer Centre, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Breast Disease, Henan Breast Cancer Centre, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalAbstract Purpose An earlier multicenter phase III study demonstrated the safety and efficacy of mitoxantrone hydrochloride injection for tracing (MHI) for detecting sentinel lymph nodes (SLNs) in breast cancer patients. This ancillary study was conducted to further analyze and discover differences between the two tracers that had not been reported previously. Methods This analysis used single-center data from a phase III trial. Patients with breast cancer were injected with both MHI and 99mTc as SLN tracers before surgery. To account for cluster effects of multiple SLNs from the same patient and further analyze the differences between the two methods and factors that could impact detection, Obuchowski’s modified McNemar test, the GLIMMIX model, and univariate and multivariate analyses were used as appropriate. Results In total, 463 SLNs from 109 patients were resected, 47 of which were pathologically positive. The SLN detection rate did not significantly differ between MHI and 99mTc. MHI blue staining was an independent predictor of pathological positivity (OR 3.58, 95% CI: 1.21–10.60, p = 0.02), while the 99mTc signal was not significant in the same model (p = 0.39). Conclusion MHI was comparable to 99mTc in safety and SLN detection rates but differed in sensitivity on positive SLNs.https://doi.org/10.1186/s12885-025-13618-xSentinel lymph node biopsySLN99mTcMitoxantrone hydrochloride injection for tracingBreast cancer |
| spellingShingle | Dechuang Jiao Xiuchun Chen Xianfu Sun Zhenduo Lu Hao Dai Chengzheng Wang Chongjian Zhang Lianfang Li Jianghua Qiao Zhenzhen Liu A comparative study of mitoxantrone hydrochloride injection and technetium-99 m for tracing axillary sentinel nodes in patients with breast cancer BMC Cancer Sentinel lymph node biopsy SLN 99mTc Mitoxantrone hydrochloride injection for tracing Breast cancer |
| title | A comparative study of mitoxantrone hydrochloride injection and technetium-99 m for tracing axillary sentinel nodes in patients with breast cancer |
| title_full | A comparative study of mitoxantrone hydrochloride injection and technetium-99 m for tracing axillary sentinel nodes in patients with breast cancer |
| title_fullStr | A comparative study of mitoxantrone hydrochloride injection and technetium-99 m for tracing axillary sentinel nodes in patients with breast cancer |
| title_full_unstemmed | A comparative study of mitoxantrone hydrochloride injection and technetium-99 m for tracing axillary sentinel nodes in patients with breast cancer |
| title_short | A comparative study of mitoxantrone hydrochloride injection and technetium-99 m for tracing axillary sentinel nodes in patients with breast cancer |
| title_sort | comparative study of mitoxantrone hydrochloride injection and technetium 99 m for tracing axillary sentinel nodes in patients with breast cancer |
| topic | Sentinel lymph node biopsy SLN 99mTc Mitoxantrone hydrochloride injection for tracing Breast cancer |
| url | https://doi.org/10.1186/s12885-025-13618-x |
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