Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome
Immune-mediated neuromuscular disorders include pathologies of the peripheral nervous system, neuromuscular junction, and muscles. If overlap syndromes (or the association of almost two autoimmune disorders) are recognized, the simultaneous occurrence of several autoimmune neuromuscular disorders is...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/6108234 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849304645426479104 |
|---|---|
| author | Stéphane Mathis Laurent Magy Philippe Corcia Karima Ghorab Laurence Richard Jonathan Ciron Mathilde Duchesne Jean-Michel Vallat |
| author_facet | Stéphane Mathis Laurent Magy Philippe Corcia Karima Ghorab Laurence Richard Jonathan Ciron Mathilde Duchesne Jean-Michel Vallat |
| author_sort | Stéphane Mathis |
| collection | DOAJ |
| description | Immune-mediated neuromuscular disorders include pathologies of the peripheral nervous system, neuromuscular junction, and muscles. If overlap syndromes (or the association of almost two autoimmune disorders) are recognized, the simultaneous occurrence of several autoimmune neuromuscular disorders is rare. We describe two patients presenting the simultaneous occurrence of inflammatory neuropathy, myositis, and myasthenia gravis (with positive acetylcholine receptor antibodies). For each patient, we carried out a pathological analysis (nerve and muscle) and an electrophysiological study (and follow-up). To our knowledge, this is the first description of such a triple immune-mediated neuromuscular syndrome. We compared our observations with a few other cases of simultaneous diagnosis of two inflammatory neuromuscular disorders. |
| format | Article |
| id | doaj-art-4193893c8e714f13b288d3af0a71db23 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-4193893c8e714f13b288d3af0a71db232025-08-20T03:55:40ZengWileyCase Reports in Neurological Medicine2090-66682090-66762016-01-01201610.1155/2016/61082346108234Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic SyndromeStéphane Mathis0Laurent Magy1Philippe Corcia2Karima Ghorab3Laurence Richard4Jonathan Ciron5Mathilde Duchesne6Jean-Michel Vallat7Department of Neurology, Nerve-Muscle Unit, CHU Bordeaux (Groupe Hospitalier Pellegrin), place Amélie-Raba-Léon, 33000 Bordeaux, FranceDepartment of Neurology, Centre de Référence “Neuropathies Périphériques Rares”, CHU Limoges, 2 avenue Martin Luther King, 87042 Limoges, FranceDepartment of Neurology, CHU Bretonneau, 2 boulevard Tonnellé, 37044 Tours, FranceDepartment of Neurology, Centre de Référence “Neuropathies Périphériques Rares”, CHU Limoges, 2 avenue Martin Luther King, 87042 Limoges, FranceDepartment of Neurology, Centre de Référence “Neuropathies Périphériques Rares”, CHU Limoges, 2 avenue Martin Luther King, 87042 Limoges, FranceDepartment of Neurology, CHU Poitiers, 2 rue de la Milétrie, 86021 Poitiers, FranceDepartment of Neurology, Centre de Référence “Neuropathies Périphériques Rares”, CHU Limoges, 2 avenue Martin Luther King, 87042 Limoges, FranceDepartment of Neurology, Centre de Référence “Neuropathies Périphériques Rares”, CHU Limoges, 2 avenue Martin Luther King, 87042 Limoges, FranceImmune-mediated neuromuscular disorders include pathologies of the peripheral nervous system, neuromuscular junction, and muscles. If overlap syndromes (or the association of almost two autoimmune disorders) are recognized, the simultaneous occurrence of several autoimmune neuromuscular disorders is rare. We describe two patients presenting the simultaneous occurrence of inflammatory neuropathy, myositis, and myasthenia gravis (with positive acetylcholine receptor antibodies). For each patient, we carried out a pathological analysis (nerve and muscle) and an electrophysiological study (and follow-up). To our knowledge, this is the first description of such a triple immune-mediated neuromuscular syndrome. We compared our observations with a few other cases of simultaneous diagnosis of two inflammatory neuromuscular disorders.http://dx.doi.org/10.1155/2016/6108234 |
| spellingShingle | Stéphane Mathis Laurent Magy Philippe Corcia Karima Ghorab Laurence Richard Jonathan Ciron Mathilde Duchesne Jean-Michel Vallat Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome Case Reports in Neurological Medicine |
| title | Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome |
| title_full | Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome |
| title_fullStr | Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome |
| title_full_unstemmed | Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome |
| title_short | Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome |
| title_sort | simultaneous combined myositis inflammatory polyneuropathy and overlap myasthenic syndrome |
| url | http://dx.doi.org/10.1155/2016/6108234 |
| work_keys_str_mv | AT stephanemathis simultaneouscombinedmyositisinflammatorypolyneuropathyandoverlapmyasthenicsyndrome AT laurentmagy simultaneouscombinedmyositisinflammatorypolyneuropathyandoverlapmyasthenicsyndrome AT philippecorcia simultaneouscombinedmyositisinflammatorypolyneuropathyandoverlapmyasthenicsyndrome AT karimaghorab simultaneouscombinedmyositisinflammatorypolyneuropathyandoverlapmyasthenicsyndrome AT laurencerichard simultaneouscombinedmyositisinflammatorypolyneuropathyandoverlapmyasthenicsyndrome AT jonathanciron simultaneouscombinedmyositisinflammatorypolyneuropathyandoverlapmyasthenicsyndrome AT mathildeduchesne simultaneouscombinedmyositisinflammatorypolyneuropathyandoverlapmyasthenicsyndrome AT jeanmichelvallat simultaneouscombinedmyositisinflammatorypolyneuropathyandoverlapmyasthenicsyndrome |