B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer

B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer

Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype often characterized by high lymphocyte infiltration, including tumor-infiltrating B cells (TIBs). These cells are present even in early stages of TNBC and associated with microinvasion. This study shows that co-culturing TNBC cel...

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Bibliographic Details
Main Authors: Nicole J. Toney, Lynn M. Opdenaker, Lisa Frerichs, Shirin R. Modarai, Aihui Ma, Holly Archinal, Grace O. Ajayi, Jennifer Sims-Mourtada
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Breast cancer
Triple negative breast cancer
Interleukin 1 beta
B cells
NFkappa B
Online Access:https://doi.org/10.1038/s41598-025-86064-1
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