The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in rats
ABSTRACT Ducrosia anethifolia has been recommended as a remedy for neurological disorders. However, the anticonvulsant effects of D. anethifolia essential oil (DAEO) and its major constituent α-pinene have not yet been clarified. Methods: A rat model of pentylenetetrazole (PTZ)-induced convulsions...
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| Series: | Arquivos de Neuro-Psiquiatria |
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| author | Mahnaz Zamyad Mehdi Abbasnejad Saeed Esmaeili-Mahani Ali Mostafavi Vahid Sheibani |
| author_facet | Mahnaz Zamyad Mehdi Abbasnejad Saeed Esmaeili-Mahani Ali Mostafavi Vahid Sheibani |
| author_sort | Mahnaz Zamyad |
| collection | DOAJ |
| description | ABSTRACT Ducrosia anethifolia has been recommended as a remedy for neurological disorders. However, the anticonvulsant effects of D. anethifolia essential oil (DAEO) and its major constituent α-pinene have not yet been clarified. Methods: A rat model of pentylenetetrazole (PTZ)-induced convulsions was used. Oxidant and antioxidant parameters were assayed in the temporal lobe. Results: The data showed that DAEO (50, 100 and 200 mg/kg, i.p.) and α-pinene (0.2 and 0.4 mg/kg i.p.) delayed the initiation time, and reduced the duration of myoclonic and tonic-clonic seizures following PTZ injection. The PTZ produced oxidative stress so that malondialdehyde and hydrogen peroxide levels were increased and catalase and peroxidase activity decreased. Pretreatment with DAEO and α-pinene significantly inhibited the above-mentioned enzymatic changes in PTZ-treated animals. Conclusion: The results suggest that α-pinene, at teast in part, was responsible for the induction of the anticonvulsant and antioxidant effects of DAEO in rats. |
| format | Article |
| id | doaj-art-41904a6dd40949e1aeddaff3c4b359ea |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-41904a6dd40949e1aeddaff3c4b359ea2025-08-20T01:56:41ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-422777210611410.1590/0004-282x20180147S0004-282X2019000200106The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in ratsMahnaz ZamyadMehdi AbbasnejadSaeed Esmaeili-MahaniAli MostafaviVahid SheibaniABSTRACT Ducrosia anethifolia has been recommended as a remedy for neurological disorders. However, the anticonvulsant effects of D. anethifolia essential oil (DAEO) and its major constituent α-pinene have not yet been clarified. Methods: A rat model of pentylenetetrazole (PTZ)-induced convulsions was used. Oxidant and antioxidant parameters were assayed in the temporal lobe. Results: The data showed that DAEO (50, 100 and 200 mg/kg, i.p.) and α-pinene (0.2 and 0.4 mg/kg i.p.) delayed the initiation time, and reduced the duration of myoclonic and tonic-clonic seizures following PTZ injection. The PTZ produced oxidative stress so that malondialdehyde and hydrogen peroxide levels were increased and catalase and peroxidase activity decreased. Pretreatment with DAEO and α-pinene significantly inhibited the above-mentioned enzymatic changes in PTZ-treated animals. Conclusion: The results suggest that α-pinene, at teast in part, was responsible for the induction of the anticonvulsant and antioxidant effects of DAEO in rats.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019000200106&lng=en&tlng=enDucrosia anethifoliaα-pinenePentilenotetrazolCriseEstresse oxidativo |
| spellingShingle | Mahnaz Zamyad Mehdi Abbasnejad Saeed Esmaeili-Mahani Ali Mostafavi Vahid Sheibani The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in rats Arquivos de Neuro-Psiquiatria Ducrosia anethifolia α-pinene Pentilenotetrazol Crise Estresse oxidativo |
| title | The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in rats |
| title_full | The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in rats |
| title_fullStr | The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in rats |
| title_full_unstemmed | The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in rats |
| title_short | The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in rats |
| title_sort | anticonvulsant effects of ducrosia anethifolia boiss essential oil are produced by its main component alpha pinene in rats |
| topic | Ducrosia anethifolia α-pinene Pentilenotetrazol Crise Estresse oxidativo |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019000200106&lng=en&tlng=en |
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