Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors
Germ-cell tumors (GCTs) are highly curable with chemotherapy. Salvage chemotherapy or surgery can cure a proportion of patients, but the ones failing these treatments will die of their disease in the young age. Immune checkpoint pathways are emerging as powerful targetable biomarkers, and a signific...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2018/3718165 |
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| _version_ | 1849304829996826624 |
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| author | Michal Chovanec Ugo De Giorgi Michal Mego |
| author_facet | Michal Chovanec Ugo De Giorgi Michal Mego |
| author_sort | Michal Chovanec |
| collection | DOAJ |
| description | Germ-cell tumors (GCTs) are highly curable with chemotherapy. Salvage chemotherapy or surgery can cure a proportion of patients, but the ones failing these treatments will die of their disease in the young age. Immune checkpoint pathways are emerging as powerful targetable biomarkers, and a significant preclinical and clinical research is underway to widen our knowledge and expand the treatment possibilities with immune therapy. The concept of immune modulation that was currently adopted in many solid tumors is understudied in GCTs. Herein, we summarize the current knowledge of published literature discussing the immune mechanisms and immune therapy in GCTs. |
| format | Article |
| id | doaj-art-4183df80845d4c61a4d81aa0d4b93ece |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-4183df80845d4c61a4d81aa0d4b93ece2025-08-20T03:55:39ZengWileyAdvances in Urology1687-63691687-63772018-01-01201810.1155/2018/37181653718165Immune-Related Concepts in Biology and Treatment of Germ-Cell TumorsMichal Chovanec0Ugo De Giorgi1Michal Mego22nd Department of Oncology, Faculty of Medicine, Comenius University, National Cancer Institute, Bratislava, SlovakiaMedical Oncology Department, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), IRCCS, Via Piero Maroncelli 40, 47014 Meldola, Italy2nd Department of Oncology, Faculty of Medicine, Comenius University, National Cancer Institute, Bratislava, SlovakiaGerm-cell tumors (GCTs) are highly curable with chemotherapy. Salvage chemotherapy or surgery can cure a proportion of patients, but the ones failing these treatments will die of their disease in the young age. Immune checkpoint pathways are emerging as powerful targetable biomarkers, and a significant preclinical and clinical research is underway to widen our knowledge and expand the treatment possibilities with immune therapy. The concept of immune modulation that was currently adopted in many solid tumors is understudied in GCTs. Herein, we summarize the current knowledge of published literature discussing the immune mechanisms and immune therapy in GCTs.http://dx.doi.org/10.1155/2018/3718165 |
| spellingShingle | Michal Chovanec Ugo De Giorgi Michal Mego Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors Advances in Urology |
| title | Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors |
| title_full | Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors |
| title_fullStr | Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors |
| title_full_unstemmed | Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors |
| title_short | Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors |
| title_sort | immune related concepts in biology and treatment of germ cell tumors |
| url | http://dx.doi.org/10.1155/2018/3718165 |
| work_keys_str_mv | AT michalchovanec immunerelatedconceptsinbiologyandtreatmentofgermcelltumors AT ugodegiorgi immunerelatedconceptsinbiologyandtreatmentofgermcelltumors AT michalmego immunerelatedconceptsinbiologyandtreatmentofgermcelltumors |