Morphology of bronchial epithelium in rodent streptozotocin-induced diabetes mellitus
Aim. To study the morphology of bronchial epithelium in a rodent streptozotocin-induced (STZ) diabetes mellitus. Materials and Methods. . Diabetes mellitus was introduced in 47 white Wistar rats aged 5?6 months (body weight 234.0?2.64 g). 43 white Wistar rats of the same age were used as control...
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Endocrinology Research Centre
2013-12-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6258 |
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| author | Oksana Anatolyevna Pivovarova Boris Nikitich Mankovsky |
| author_facet | Oksana Anatolyevna Pivovarova Boris Nikitich Mankovsky |
| author_sort | Oksana Anatolyevna Pivovarova |
| collection | DOAJ |
| description | Aim. To study the morphology of bronchial epithelium in a rodent streptozotocin-induced (STZ) diabetes mellitus. Materials and Methods. . Diabetes mellitus was introduced in 47 white Wistar rats aged 5?6 months (body weight 234.0?2.64 g). 43 white Wistar rats of the same age were used as control subjects (body weight 242.0?2.13). Diabetes was induced by single intraperitoneal injection of STZ (SIGMA, USA) 60 mg/kg in 0.1 M citrate buffer, pH 4.5. Results. A statistically significant decrease in the total epithelial area by 25.9% was observed in the study group, accompanied by a reduction of the supranuclear zone by 22.1% vs. the control group. Conclusion. We found that bronchial mucous membrane in rodents with STZ-induced diabetes mellitus exhibits signs of atrophy and partial loss of mucous production by bronchial secretory cells. |
| format | Article |
| id | doaj-art-417d78cc76b34f929cbfcdf85915c710 |
| institution | OA Journals |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-417d78cc76b34f929cbfcdf85915c7102025-08-20T01:57:09ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782013-12-01164444810.14341/DM2013444-486216Morphology of bronchial epithelium in rodent streptozotocin-induced diabetes mellitusOksana Anatolyevna Pivovarova0Boris Nikitich Mankovsky1State Establishment "Lugansk State Medical University", LuganskP.L.Shupik National Medical Academy of post-graduate education, KievAim. To study the morphology of bronchial epithelium in a rodent streptozotocin-induced (STZ) diabetes mellitus. Materials and Methods. . Diabetes mellitus was introduced in 47 white Wistar rats aged 5?6 months (body weight 234.0?2.64 g). 43 white Wistar rats of the same age were used as control subjects (body weight 242.0?2.13). Diabetes was induced by single intraperitoneal injection of STZ (SIGMA, USA) 60 mg/kg in 0.1 M citrate buffer, pH 4.5. Results. A statistically significant decrease in the total epithelial area by 25.9% was observed in the study group, accompanied by a reduction of the supranuclear zone by 22.1% vs. the control group. Conclusion. We found that bronchial mucous membrane in rodents with STZ-induced diabetes mellitus exhibits signs of atrophy and partial loss of mucous production by bronchial secretory cells.https://www.dia-endojournals.ru/jour/article/view/6258streptozotocin-induced diabetesbronchimorphology |
| spellingShingle | Oksana Anatolyevna Pivovarova Boris Nikitich Mankovsky Morphology of bronchial epithelium in rodent streptozotocin-induced diabetes mellitus Сахарный диабет streptozotocin-induced diabetes bronchi morphology |
| title | Morphology of bronchial epithelium in rodent streptozotocin-induced diabetes mellitus |
| title_full | Morphology of bronchial epithelium in rodent streptozotocin-induced diabetes mellitus |
| title_fullStr | Morphology of bronchial epithelium in rodent streptozotocin-induced diabetes mellitus |
| title_full_unstemmed | Morphology of bronchial epithelium in rodent streptozotocin-induced diabetes mellitus |
| title_short | Morphology of bronchial epithelium in rodent streptozotocin-induced diabetes mellitus |
| title_sort | morphology of bronchial epithelium in rodent streptozotocin induced diabetes mellitus |
| topic | streptozotocin-induced diabetes bronchi morphology |
| url | https://www.dia-endojournals.ru/jour/article/view/6258 |
| work_keys_str_mv | AT oksanaanatolyevnapivovarova morphologyofbronchialepitheliuminrodentstreptozotocininduceddiabetesmellitus AT borisnikitichmankovsky morphologyofbronchialepitheliuminrodentstreptozotocininduceddiabetesmellitus |