Hodgkin’s Lymphoma Revealed by Hemophagocytic Lymphohistiocytosis in a Child
Hemophagocytic lymphohistiocytosis (HLH) is a severe life-threatening disorder, responsible for extensive phagocytosis of hematopoietic cells and causing a multisystem organ failure. If lymphomas are common causes of HLH, the association with Hodgkin’s lymphoma is rarely described in children. We re...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2014/851392 |
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| author | Sarra Benmiloud Mohamed Hbibi Sana Chaouki Sana Abourazzak Moustapha Hida |
| author_facet | Sarra Benmiloud Mohamed Hbibi Sana Chaouki Sana Abourazzak Moustapha Hida |
| author_sort | Sarra Benmiloud |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis (HLH) is a severe life-threatening disorder, responsible for extensive phagocytosis of hematopoietic cells and causing a multisystem organ failure. If lymphomas are common causes of HLH, the association with Hodgkin’s lymphoma is rarely described in children. We report a case of a 9-year-old boy presenting with HLH as an initial manifestation of Hodgkin’s lymphoma. He has been suffering from persistent high fever, asthenia, weight loss, and hepatosplenomegaly with no lymphadenopathy. The diagnosis of HLH secondary to infectious disease was initially worn. The patient received high-dose intravenous immunoglobulin with broad-spectrum antibiotics. However, his state got worse with the onset of dry cough and pleural effusion. Histopathologic examination of pleural fluid showed the presence of Reed-Sternberg cells. The outcome was favorable after treatment by corticosteroid and chemotherapy. Hodgkin’s lymphoma revealed by HLH is a source of delayed diagnosis and should be borne in mind in children. |
| format | Article |
| id | doaj-art-417cf19a49414fcd9e37f0de0e06a9a2 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-417cf19a49414fcd9e37f0de0e06a9a22025-08-20T03:55:40ZengWileyCase Reports in Pediatrics2090-68032090-68112014-01-01201410.1155/2014/851392851392Hodgkin’s Lymphoma Revealed by Hemophagocytic Lymphohistiocytosis in a ChildSarra Benmiloud0Mohamed Hbibi1Sana Chaouki2Sana Abourazzak3Moustapha Hida4Unit of Pediatric Hematology-Oncology, Department of Pediatrics, University Hospital Hassan II, Faculty of Medicine and Pharmacy, University of Sidi Mohamed Ben Abdellah, 30000 Fez, MoroccoUnit of Pediatric Hematology-Oncology, Department of Pediatrics, University Hospital Hassan II, Faculty of Medicine and Pharmacy, University of Sidi Mohamed Ben Abdellah, 30000 Fez, MoroccoUnit of Pediatric Hematology-Oncology, Department of Pediatrics, University Hospital Hassan II, Faculty of Medicine and Pharmacy, University of Sidi Mohamed Ben Abdellah, 30000 Fez, MoroccoUnit of Pediatric Hematology-Oncology, Department of Pediatrics, University Hospital Hassan II, Faculty of Medicine and Pharmacy, University of Sidi Mohamed Ben Abdellah, 30000 Fez, MoroccoUnit of Pediatric Hematology-Oncology, Department of Pediatrics, University Hospital Hassan II, Faculty of Medicine and Pharmacy, University of Sidi Mohamed Ben Abdellah, 30000 Fez, MoroccoHemophagocytic lymphohistiocytosis (HLH) is a severe life-threatening disorder, responsible for extensive phagocytosis of hematopoietic cells and causing a multisystem organ failure. If lymphomas are common causes of HLH, the association with Hodgkin’s lymphoma is rarely described in children. We report a case of a 9-year-old boy presenting with HLH as an initial manifestation of Hodgkin’s lymphoma. He has been suffering from persistent high fever, asthenia, weight loss, and hepatosplenomegaly with no lymphadenopathy. The diagnosis of HLH secondary to infectious disease was initially worn. The patient received high-dose intravenous immunoglobulin with broad-spectrum antibiotics. However, his state got worse with the onset of dry cough and pleural effusion. Histopathologic examination of pleural fluid showed the presence of Reed-Sternberg cells. The outcome was favorable after treatment by corticosteroid and chemotherapy. Hodgkin’s lymphoma revealed by HLH is a source of delayed diagnosis and should be borne in mind in children.http://dx.doi.org/10.1155/2014/851392 |
| spellingShingle | Sarra Benmiloud Mohamed Hbibi Sana Chaouki Sana Abourazzak Moustapha Hida Hodgkin’s Lymphoma Revealed by Hemophagocytic Lymphohistiocytosis in a Child Case Reports in Pediatrics |
| title | Hodgkin’s Lymphoma Revealed by Hemophagocytic Lymphohistiocytosis in a Child |
| title_full | Hodgkin’s Lymphoma Revealed by Hemophagocytic Lymphohistiocytosis in a Child |
| title_fullStr | Hodgkin’s Lymphoma Revealed by Hemophagocytic Lymphohistiocytosis in a Child |
| title_full_unstemmed | Hodgkin’s Lymphoma Revealed by Hemophagocytic Lymphohistiocytosis in a Child |
| title_short | Hodgkin’s Lymphoma Revealed by Hemophagocytic Lymphohistiocytosis in a Child |
| title_sort | hodgkin s lymphoma revealed by hemophagocytic lymphohistiocytosis in a child |
| url | http://dx.doi.org/10.1155/2014/851392 |
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