Socioeconomic disparities in the associations of age at last live birth with stroke and its subtypes among Chinese parous postmenopausal women: A prospective cohort study
Background: As a pivotal reproductive factor, age at last live birth (ALLB) plays a critical role in a woman's health trajectory, including the risk of cardiovascular diseases. Methods: In this prospective cohort study from the China Kadoorie Biobank (CKB), 148,456 parous postmenopausal women w...
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Elsevier
2025-08-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556525001202 |
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| author | Shiyi Shan Weidi Sun Jing Wu Leying Hou Zeyu Luo Jiali Zhou Jiayao Ying Peige Song |
| author_facet | Shiyi Shan Weidi Sun Jing Wu Leying Hou Zeyu Luo Jiali Zhou Jiayao Ying Peige Song |
| author_sort | Shiyi Shan |
| collection | DOAJ |
| description | Background: As a pivotal reproductive factor, age at last live birth (ALLB) plays a critical role in a woman's health trajectory, including the risk of cardiovascular diseases. Methods: In this prospective cohort study from the China Kadoorie Biobank (CKB), 148,456 parous postmenopausal women were included. ALLB was further classified equally into tertiles (<26 years, 26–29 years, and ≥30 years). Total stroke and its three subtypes (ischemic stroke [IS], intracerebral hemorrhage [ICH], and subarachnoid hemorrhage [SAH]) were identified as outcomes. Cox proportional hazard regression was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the associations of ALLB with incident stroke and its subtypes. Latent class analysis (LCA) was employed to explore underlying socioeconomic status (SES) classes within women in urban and rural areas, and SES-stratified analysis was conducted. Population attributable fraction (PAF) was estimated to assess the impact of later ALLB on stroke at the population level. Results: Compared with women with ALLB of <26 years, women with later ALLB (26–29 years and ≥ 30 years) faced a higher risk of stroke, with the highest fully adjusted HRs (aHRs) observed in women whose ALLB was ≥30 years (total stroke: 3.88, 95 % CI 3.71–4.07; IS: 5.33, 95 % CI 5.05–5.63; ICH: 3.79, 95 % CI 3.36–4.29; SAH: 4.93, 95 % CI 3.41–7.12). The strongest associations were found among rural-low-SES participants with total stroke and IS, with aHRs of 5.61 (95 % CI 5.12–6.16) and 7.28 (95 % CI 6.51–8.14) for an ALLB of ≥30 years. The highest PAF of total stroke with ALLB ≥26 years was observed in rural-middle-SES individuals, with value of 59.15 % (95 % CI 56.80–61.48). Conclusion: Later ALLB was associated with an increased risk of stroke among Chinese parous postmenopausal women, notably in lower socioeconomic rural populations. |
| format | Article |
| id | doaj-art-417b75890d744869a39b068cfb679cb3 |
| institution | DOAJ |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
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| series | Experimental Gerontology |
| spelling | doaj-art-417b75890d744869a39b068cfb679cb32025-08-20T03:07:17ZengElsevierExperimental Gerontology1873-68152025-08-0120711279110.1016/j.exger.2025.112791Socioeconomic disparities in the associations of age at last live birth with stroke and its subtypes among Chinese parous postmenopausal women: A prospective cohort studyShiyi Shan0Weidi Sun1Jing Wu2Leying Hou3Zeyu Luo4Jiali Zhou5Jiayao Ying6Peige Song7Center for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, ChinaCenter for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, ChinaCenter for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, ChinaCenter for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, ChinaCenter for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, ChinaCenter for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, ChinaCenter for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, ChinaCorresponding author at: Center for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, Hangzhou 310058, China.; Center for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, ChinaBackground: As a pivotal reproductive factor, age at last live birth (ALLB) plays a critical role in a woman's health trajectory, including the risk of cardiovascular diseases. Methods: In this prospective cohort study from the China Kadoorie Biobank (CKB), 148,456 parous postmenopausal women were included. ALLB was further classified equally into tertiles (<26 years, 26–29 years, and ≥30 years). Total stroke and its three subtypes (ischemic stroke [IS], intracerebral hemorrhage [ICH], and subarachnoid hemorrhage [SAH]) were identified as outcomes. Cox proportional hazard regression was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the associations of ALLB with incident stroke and its subtypes. Latent class analysis (LCA) was employed to explore underlying socioeconomic status (SES) classes within women in urban and rural areas, and SES-stratified analysis was conducted. Population attributable fraction (PAF) was estimated to assess the impact of later ALLB on stroke at the population level. Results: Compared with women with ALLB of <26 years, women with later ALLB (26–29 years and ≥ 30 years) faced a higher risk of stroke, with the highest fully adjusted HRs (aHRs) observed in women whose ALLB was ≥30 years (total stroke: 3.88, 95 % CI 3.71–4.07; IS: 5.33, 95 % CI 5.05–5.63; ICH: 3.79, 95 % CI 3.36–4.29; SAH: 4.93, 95 % CI 3.41–7.12). The strongest associations were found among rural-low-SES participants with total stroke and IS, with aHRs of 5.61 (95 % CI 5.12–6.16) and 7.28 (95 % CI 6.51–8.14) for an ALLB of ≥30 years. The highest PAF of total stroke with ALLB ≥26 years was observed in rural-middle-SES individuals, with value of 59.15 % (95 % CI 56.80–61.48). Conclusion: Later ALLB was associated with an increased risk of stroke among Chinese parous postmenopausal women, notably in lower socioeconomic rural populations.http://www.sciencedirect.com/science/article/pii/S0531556525001202Age at last live birthStrokeParous postmenopausal womenSocioeconomic statusResidence |
| spellingShingle | Shiyi Shan Weidi Sun Jing Wu Leying Hou Zeyu Luo Jiali Zhou Jiayao Ying Peige Song Socioeconomic disparities in the associations of age at last live birth with stroke and its subtypes among Chinese parous postmenopausal women: A prospective cohort study Experimental Gerontology Age at last live birth Stroke Parous postmenopausal women Socioeconomic status Residence |
| title | Socioeconomic disparities in the associations of age at last live birth with stroke and its subtypes among Chinese parous postmenopausal women: A prospective cohort study |
| title_full | Socioeconomic disparities in the associations of age at last live birth with stroke and its subtypes among Chinese parous postmenopausal women: A prospective cohort study |
| title_fullStr | Socioeconomic disparities in the associations of age at last live birth with stroke and its subtypes among Chinese parous postmenopausal women: A prospective cohort study |
| title_full_unstemmed | Socioeconomic disparities in the associations of age at last live birth with stroke and its subtypes among Chinese parous postmenopausal women: A prospective cohort study |
| title_short | Socioeconomic disparities in the associations of age at last live birth with stroke and its subtypes among Chinese parous postmenopausal women: A prospective cohort study |
| title_sort | socioeconomic disparities in the associations of age at last live birth with stroke and its subtypes among chinese parous postmenopausal women a prospective cohort study |
| topic | Age at last live birth Stroke Parous postmenopausal women Socioeconomic status Residence |
| url | http://www.sciencedirect.com/science/article/pii/S0531556525001202 |
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